4/4
Goal by end of year: a novel drug target and a validated molecule. Not a clinical therapy — but the kind of timeline
compression that makes underserved diseases economically viable again.
Read more from Drug Discovery world -> www.ddw-online.com/can-ai-shrin...
3/4
The setup: DeepKnowledge scans ~3M papers for targets. Balto runs virtual screening and molecular design. Arctoris' robotic lab Ulysses tests predictions autonomously. Data returns, models refine, cycle repeats.
2/4
ARIA awarded £500k to test whether AI + autonomous labs can compress drug discovery from years to months. We chose endometriosis because our AI independently flagged it as the highest unmet need in women's health.
1/4
1 in 10 women have endometriosis. No approved disease-modifying drug. 9-year average diagnostic delay.
Our AI Scientist project with Arctoris just got featured in Drug Discovery World.
Good start to the week 🕶️ - featured in two routine reads for our team Where Tech Meets Bio and BioPharmaTrend.com - read more about our AI Scientist tasked with autonomously advancing endometriosis research below 👇
🔗s:
www.techlifesci.com/p/weekly-tec...
www.biopharmatrend.com/news/uks-ari...
See how we explored the KRAS G12D landscape and uncovered top candidate molecules — all without leaving the conversation. deeporigin.com/blog/finding-promising-molecules-and-biological-background-with-balto
#AI #Pharmaceuticals #DrugDiscovery #Bioinformatics
For more information on ARIA's AI Scientist programs: www.aria.org.uk/ai-scientist...
Interested in trying it out on your own:
Design molecules against targets: www.deeporigin.com/balto-ai-ass...
Extract molecules from the literature and patents: www.deeporigin.com/do-patent
Excited to join the AI Scientist program from ARIA! 🧬
With our predictive ADME-Tox models we're developing through @ARPA-H CATALYST, we're building a world where science is faster and more successful, leading to medicines sooner.
You can already try parts of this vision with Balto + DO Patent 👇
We still redraw molecules by hand from PDFs in 2026.
That’s wild.
So we built DO Patent:
• 98%+ accurate full-molecule extraction
• PDFs → SMILES in minutes
• Confidence scores + source traceability
Try it free:
www.deeporigin.com/blog/we-buil...
#DrugDiscovery #Cheminformatics #AI #Biotech #Patents
Big news at Deep Origin: we’re leading a $31.7M ARPA-H award to build in-silico models that could replace animal testing.
Animal studies are slow, costly, and often fail to predict human biology.
Read more here 👉 www.deeporigin.com/blog/arpa-h-...
GenAI is getting better, but science needs more than text. Claude shows AI must use tools and real data—but chemistry is different: structures, pockets, ADMET, simulations. We dug into what GenAI can/can’t do for chemists + Balto’s 86% LitQA2 score below 👇
www.deeporigin.com/blog/out-of-...
Shout out to Deep Origin team member Aleks Grigoryan who wasn’t satisfied with just being proud of his team on the ground, but took it to the sky and made it loud! 🚀 🪂 🧬
One of our much loved team members (and an all around great human being) Kate was in a horrible accident. If you have the means or time to share or contribute to her recovery fund, you will be helping to make the world a brighter place:
gofund.me/9553c9134
In our new blog post, we dive into:
🔺 Limits of global docking models
🔺 False positives & cryptic pockets
🔺 How Deep Origin PocketFinder (in Balto) boosts accuracy
🔺 >80% success in recovering real binding sites
www.deeporigin.com/blog/a-blind...
We're excited to be at #ARDD2025 — the premier conference focused on advancing therapies for aging and age-related diseases. As the field moves from breakthrough research to real-world impact, Deep Origin is here to explore the future of collab with biotech and pharma leaders shaping what comes next
Using our OncoSim toolkit—combining ML + mechanistic models across 1,000+ cancer cell lines—we’ve predicted 100+ novel synthetic lethal pairs. Some are validated and may guide therapy & resistance prediction.
Poster by Oliver Purcell @ GRC👇
www.deeporigin.com/academic-pos...
Thrilled to share our co-founder and CSO Garegin Papoian in Nature!
Actin cytoskeleton stores stress, unleashing sudden “cytoquakes”. Murrell @ Yale and Papoian @ UMD show orderly filaments diffuse force; tangled networks give power-law bursts.
Read more 👉 nature.com/articles/s41567-025-02919-4
This summer, we're is opening its doors in Yerevan to curious, driven, and technically skilled students for a 10–12 week paid internship in biosimulations and protein modeling.
Starts: End of June
Location: Yerevan, Armenia
Duration: 10–12 weeks
Paid internship
apply.workable.com/deeporigin/j...
We’ve developed a hybrid MM/NNP framework. It delivers high-accuracy solvation and binding ΔG predictions at an average throughput of ~600 ns/day on CPU—10× faster than GPU-based approaches.
Check out our scientific poster below 👇
www.deeporigin.com/academic-pos...
DO Challenge — is a new benchmark designed to test autonomous agentic systems in a resource-constrained, simulated drug discovery environment.
We applied it to our own agentic system, Deep Thought, comparing its performance against human teams.
See what we found 👇
arxiv.org/abs/2504.19912
We had a great time at #ACSSpring2025! From presenting posters, to hosting a great happy hour, to seeing what's new in chemistry, the energy in-person is great!
We'll share our posters in the coming days. For now, stay in the loop by joining our newsletter! www.deeporigin.com/newsletter
Deep Origin Challenge has wrapped up! This year we had over 40 teams made up of over 110 talented programmers, students, data scientists, and life scientists in a 10-hour-long prediction challenge at our Yerevan office 🌄
Want to be involved next year? Stay informed 👉 www.deeporigin.com/newsletter
Headed to American Chemical Society Spring '25 expo? Join us Monday night for tacos, drinks, swag and a chance to try out Balto - our AI assistant for drug discovery - with some of the most fun scientists around!
Register below 👇
lu.ma/3sy7pqtb
Last chance to sign up for the Deep Origin challenge!
🌄 A day-long AI/ML for drug discovery hackathon
🤝 Bring a team of up to 4 (or sign up yourself)
🤖 Meet and collaborate with leading ML and drug discovery experts
💵 Compete for cash prizes
www.deeporigin.com/events/deep-...
New pub from our team - check out our Smart Distributed Data Factory (think SETI@Home but for molecules) below 👇
www.nature.com/articles/s41...
Want to download the DFT dataset or volunteer compute to create new DFT data points for the community? Find out more here: sddfactory.cloud
The #DeepOriginChallenge is back! Join us in our Yerevan office for a day of competition and collaboration building efficient #machineLearning models in small teams. Prizes up to $3k and the promise to meet leaders in AI and drug discovery.
Register below!
Aram Davtyan giving an awesome poster presentation about our work modeling protein-small molecule-protein ternary complexes at @keystonesymposia.bsky.social Proximity-Based Therapeutics! #biotech #drugDev #degraders #molecularGlues #PROTACs
Find the poster here: www.deeporigin.com/academic-pos...
