Mechanistic studies on HNRNPA2B1 suggest binding but not selective recognition of m6A HNRNPA2B1 contains two RRM domains and has been investigated for its possible role as an m6A reader protein. The targetome of HNRNPA2B1 was shown to overlap with the m6A methylation motif, but furt...

In #epitransciptomics, there is a need to measure #RNA-#protein interactions which can be problematic from RNA conformational dynamics.
The in-solution measurement on #NanoTemper Monolith X means biomolecules retain conformations for these studies
#biophysics

www.tandfonline.com/doi/full/10....

NanoTemper's Strategic Advancements in Biopharma Through Envue Acquisition and Dianthus α Launch NanoTemper has enhanced its biopharma discovery portfolio by acquiring Envue Technologies and launching the innovative Dianthus α application, driving advancements in drug discovery.

NanoTemper's Strategic Advancements in Biopharma Through Envue Acquisition and Dianthus α Launch #Germany #Munich #NanoTemper #Dianthus_α #Envue_Technologies

Many thanks to Charlotte Hunter, Stefanie Freitag-Pohl & Ehmke Pohl #Durhamuniversity for this review.
It candidly shows spectral shift detection on a #nanotemper Dianthus can #screen #macromolecular interactions in solution i.e. in (near to) natve conformation.
#biiphysics #drugdiscovery #hts

These insights will drive our future projects and enhance our capabilities. Big thank you to the #NanoTemper Technologies team and to @eu-openscreen.bsky.social for their support. Stay tuned for impactful outcomes from MEDINA! #Biophysics #Innovation #Collaboration #Nanotemper #MolecularInteractions

Molecular glues that inhibit deubiquitylase activity and inflammatory signaling - Nature Structural & Molecular Biology The BRCC36 isopeptidase complex (BRISC) is a deubiquitylase that stabilizes interferon receptors, driving inflammation. We discovered ‘BRISC molecular glue’ inhibitors (BLUEs) that selectively inactiv...

Interested in #molecularglues?
Learn how #NanoTemper Dianthus affinity tech showed novel inhibitors, BLUEs, block interactions of BRISC with SHMT2.

BLUEs inhibit #protein complexes by inducing #PP!s

Many thanks to Elton Zeqiraj et al, @universityofleeds.bsky.social

www.nature.com/articles/s41...

What motivates you to start your own biotech company? Philipp Baaske, CEO of NanoTemper, spoke today at the PioneerCampus seminar about his journey from science to business - inspiring 🚀 #HelmholtzMunich #NanoTemper

Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets Nature Communications - Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to...

For aficionados of #fragments, #degraders & #ATTECs. Learn how biophysics approaches - spectral shift detection on #NanoTemper Dianthus characterised LC3/GABARAP interactions.
From #GoetheUniversity, #SGC, #DKTK, #DKFZ. #Fraunhofer #TUM #DiamondLightSource, Nathan Adams & Ivana Jaser

rdcu.be/d22DS