Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets Nature Communications - Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to...

For aficionados of #fragments, #degraders & #ATTECs. Learn how biophysics approaches - spectral shift detection on #NanoTemper Dianthus characterised LC3/GABARAP interactions.
From #GoetheUniversity, #SGC, #DKTK, #DKFZ. #Fraunhofer #TUM #DiamondLightSource, Nathan Adams & Ivana Jaser

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