📑New review in #Glycoscience & #Therapy:
Mass spectrometry empowers #glycoRNA profiling. Simplifies analysis in glycobiology & disease diagnostics.
🔗More: https://ow.ly/ZMBy50YGUVF

What are your thoughts on this new research?
#MassSpectrometry #Glycomics #BiomarkerDiscovery #AnalyticalChemistry

It looks like the #glycoRNA commercial pipeline has found its final home (for now):
2021 - GannaBio (glycoRNA focus) start-up as part of the ReNAgade Therapeutics ecosystem
2024 - Orna Therapeutics announces strategic acquisition of ReNAgade Therapeutics
2026 - Eli Lilly to acquire Orna Therapeutics

#glycotime We hope our b2b publications serve as a heads-up for the #glycoRNA community, and drive the field forward constructively. Links👇
Kim et al. rdcu.be/eP4GQ
@nathanaelbkegel.bsky.social Kegel et al. nature.com/articles/s12276-025-01575-1 (Stefan Bauer lab)

Great perspective by @dereklowe.bsky.social on recent advances in cell surface #glycoRNA biology, including new work from @raflynn5.bsky.social and collaborators identifying an immune silencing effect of N-glycans on activation of TLRs by Acp3U-RNA (www.nature.com/articles/s41...)

RNA N-glycosylation enables immune evasion and homeostatic efferocytosis - Nature N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...

Another piece of the #glycoRNA puzzle revealed by @raflynn5.bsky.social and @vijayrathinam.bsky.social!! RNAs with modified base acp3U activate TLR3/7, but not when acp3U is N-glycosylated. This is how cell surface/secreted glycoRNAs avoid stimulating autoimmunity.

www.nature.com/articles/s41...

#RNASky #RNABiology #glycoRNA

Sugar-coated RNA A new pre-print from Caroline Bertozzi’s lab shows that some RNA molecules are glycosylated. At least some of these glyco-RNA molecules might reside inside the ER lumen.

I wrote about this possibility in my blog when @raflynn5.bsky.social 's first preprint on #glycoRNA just came out.

greenfluorescentblog.wordpress.com/2019/10/09/s...

Available online - the Technology of the Month "Tools for illuminating the cell surface glycoRNA landscape" from Yuan Ma et al.

#glycoRNA #RNABindingProteins #RBP #ARPLA #HieCo2 #MDEM #drFRET

Read it here: authors.elsevier.com/a/1lOie3S6Gf...

Extracellular exosomal RNAs are glyco-modified - Nature Cell Biology Sharma, Jiao and colleagues report glycosylation of small RNAs within exosomes and propose a glycosylation-dependent mechanism for RNA targeting into exosomes, which may influence intercellular commun...

More insights into #glycoRNA, this time found within exosomes!

www.nature.com/articles/s41...

Good wifi today.
Let's go #RNA2025
1st plenary session on RNA modification & editing.
First is @raflynn5.bsky.social on #glycoRNA of course

Maybe #glycoRNA is not so weird after all!

Available online - the Review "Cell surface RNA biology: new roles for RNA binding proteins" from Jennifer Porat and @raflynn5.bsky.social.

#RNABindingProteins #csRBP #glycosylatedRNA #glycoRNA #autoantigens #autoimmunity

authors.elsevier.com/a/1kqzo3S6Gf...

Amazing to look on as #glycoRNA and related targeting strategies show major disease relevance! Congrats to the authors #Siglec #SialicAcid #Glycotime

Enjoying the RNA Medicine Symposium @stanfordmedicine.bsky.social, featuring #glycoRNA pioneer @raflynn5.bsky.social

More discoveries around #glycoRNA #glycotime

New method for detecting cell surface RNAs highlights Y RNAs as having a role for modulating extracellular histone binding

Exciting overlap between #glycoRNA transcripts and those characterized here

www.biorxiv.org/content/10.1...

Advancing #glycoRNA imaging with FRET-based detection and expanding the scope of their presentation to extracellular vesicles - interestingly high levels of sialoglycoRNAs on blood EVs can be predictive of having cancer @naturecomms.bsky.social

www.nature.com/articles/s41...

Nice discussion around the ongoing #glycoRNA debate, check out the comments

Another heads-up for the #glycoRNA community from Uni Marburg👇There are many glycoproteins co-isolated with RNA by TRIzol method. They persist throughout RNA sample processing and are not easily degraded by proteinase K. Careful what you are looking at in an RNA blot!

Had a great time visiting @duke-university.bsky.social to share our recent work on #glycoRNA and #csRBPs and the broader ideas of cell surface RNA biology. Thanks to Kate Meyer for hosting and fun talking to Gladfelter, Boyce, Horner, and Chory labs as well as students at lunch!

RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry Mammalian cells present RNA-binding proteins on the cell surface that form clustered domains containing glycoRNAs.

Mindblowing new study by @raflynn5.bsky.social @bostonchildrens.bsky.social, cell surface RNA-binding proteins form nanoclusters with #glycoRNA and mediate cell-penetrating peptide entry into cells 👏

www.cell.com/cell/abstrac...

Fantastic work from Ryan and his team 👏 #glycoRNA

RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry Mammalian cells present RNA-binding proteins on the cell surface that form clustered domains containing glycoRNAs.

Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA.

Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...

Graphic showing modification of mRNA with ADP-ribose mediated by bacterial enzyme cmdTAC

Check it out! Another novel RNA modification - ADP-ribosylation - that was previously only known on proteins. A cousin to #glycoRNA 👏

www.nature.com/articles/s41...

Could this be useful for analyzing #glycoRNA? @raflynn5.bsky.social

Opportunity to work with #proudofalumni @raflynn5.bsky.social, discoverer of #glycoRNA and breaking all kinds of new ground in cell surface RNA biology

Editorial: Read to learn more about Induced Proximity and the articles you will find in the Special Issue. #RNATACs #Therapeutics #Velcrins #Wnt #KEAP1 #MolecularGlues #Bifunctional #PPI #glycoRNA #photocatalytic #TPD #LyTACs http://dlvr.it/T8XxZl

And a new preprint from
from Ryan Flynn, Caroline Bertozzi
on #glycoRNA
Chemical/molecular oriented, they characterize the chemical modification on the RNA that allow N-glycan binding.
"The modified RNA base acp3U is an attachment site for N-glycans in glycoRNA"
www.biorxiv.org/content/10.1...