¿Cómo los azúcares del tumor liberan el freno inmune? MIT y Stanford diseñan anticuerpo-lectina que anula azúcares tumorales y reactiva defensas, con menos metástasis en ratón y potencial clínico En un avance que apunta directamente al corazón de la inmu...

¿Cómo los azúcares del tumor liberan el freno inmune? #Cáncer #Inmunoterapia #Oncologia #Glicanos #Lectinas #AbLecs #MIT #Stanford #Siglec #Biomedicina #NatureBiotechnology #Investigación #Ciencia #18dediciembre #felizjueves donporque.com/azucares-del...

SIGLEC12 mediates plasma membrane rupture during necroptotic cell death - Nature CRISPR–Cas9-based genome-wide screening shows that SIGLEC12 mediates plasma membrane rupture in cells undergoing necroptosis, possibly through a human-specific mechanism, indicating its potential as a...

“Here, using a CRISPR–Cas9-based genome-wide knockout approach, we identify SIGLEC12 as a key mediator of necroptosis downstream of MLKL at the PMR step.” Non-sialic acid binding #Siglec #glycotime (?)

www.nature.com/articles/s41...

Increase of Inhibitory Siglec receptors on T cells mitigates severe immune reactions during acute viral infections Abstract. Expression of inhibitory Siglec receptors has been described on T cells of patients with viral infection and cancer. However, the exact function

#Siglec -9 levels increase on T cells in patients with acute severe acute respiratory syndrome coronavirus 2 (and LCMV) infection relative to levels on healthy controls
#SialicAcid #Glycotime

academic.oup.com/pnasnexus/ar...

#Siglec #SialicAcid #Glycotime

Disrupting Siglec-mediated interactions to develop immunotherapies for cancer treatment Recent advances in cancer immunotherapy have improved patient outcomes, even in advanced stages of the disease. However, the effectiveness of current cancer immunotherapies remains limited to a sma...

#Siglec #SialicAcid #Glycotime

www.tandfonline.com/doi/full/10....

✅ An exciting work from Dr. Macauley’s lab (@siglecdude.bsky.social)!
📣📣 Highly recommend to read and share this awesome story! @zeinab-jc.bsky.social #glycotime, #glycoimmunology, #Siglec, #Siglec-Liposome-tools, @glyconet.bsky.social

A Minimal Mutation Trajectory Separates Inverting and Retaining Mechanisms on the Same Sialidase Structural Scaffold The recently discovered sialidase AmGH181 from the human gut symbiont Akkermansia muciniphila is remarkably selective to the sialyl T-antigen, a glycan found on mucins and cancer cells. However, the m...

“…AmGH181 #sialidase from the human gut symbiont Akkermansia muciniphila is remarkably selective to the sialyl T-antigen…we show that specificity is governed by a flexible tryptophan–histidine pair…that precisely positions the sialyl T… for catalysis” #Siglec #SialicAcid #Glycotime

That’s all, folks!

Showing off some Paulson lab bling gifted to recent graduates! 🎓 ♦️ 💎

#Siglec #SialicAcid #Glycotime #PhD

(Super) cool work! Let’s see that #Siglec -Fc atlas next 🧐

Dear friends

I will defend my PhD Dissertaion on May15 at 14:00 PST.

Tune in to learn all about “Therpeutic Sialidase Conjugates Targeting the Glyco-Immune Axis in Cancer”.

(Link in the comments)

#Siglec #SialicAcid #Glycotime

Amazing to look on as #glycoRNA and related targeting strategies show major disease relevance! Congrats to the authors #Siglec #SialicAcid #Glycotime

Insights into stability, dimerisation, and ligand binding properties of Siglec-7: Isotope labelling in HEK293 cells for protein characterisation by NMR spectroscopy Siglec-7, an immune checkpoint receptor, has emerged as a promising target for cancer immunotherapy due to its involvement in the regulation of immune…

👇👇 Insights into stability, dimerisation, and ligand binding properties of Siglec-7: Isotope labelling in HEK293 cells for protein characterisation by NMR #Siglec #NMR #glycotime, @robertamarchetti.bsky.social

www.sciencedirect.com/science/arti...