Increase of Inhibitory Siglec receptors on T cells mitigates severe immune reactions during acute viral infections Abstract. Expression of inhibitory Siglec receptors has been described on T cells of patients with viral infection and cancer. However, the exact function

#Siglec -9 levels increase on T cells in patients with acute severe acute respiratory syndrome coronavirus 2 (and LCMV) infection relative to levels on healthy controls
#SialicAcid #Glycotime

academic.oup.com/pnasnexus/ar...

Targeting Interactions Between Siglec-10 and α3β1 Integrin Enhances Macrophage-Mediated Phagocytosis of Pancreatic Cancer AbstractTumor-associated macrophages (TAM) in the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME) exhibit immunosuppressive phenotypes and impaired phagocytic activity, facilitati...

“In this study, we identified integrin α3β1, composed of ITGA3 and ITGB1 subunits, as a sialylated glycoprotein ligand for #Siglec-10, an inhibitory glyco-immune checkpoint receptor highly expressed on TAMs in PDAC” #SialicAcid #Glycotime

aacrjournals.org/cancerres/ar...

#Siglec #SialicAcid #Glycotime

H3N2 influenza virus tropism shifts to glycan receptors on tracheal ciliated cells Human H3N2 influenza viruses, introduced during the 1968 pandemic, have evolved to recognize human-type sialic acid-containing receptors (Neu5Acα2-6Gal) extended with at least three LacNAc (Galβ1-4Glc...

New work from Dr. Kikuchi et al. in the Paulson lab @scripps.edu showing H3N2 #influenza tropism for #sialicacid on tracheal ciliated cells #glycotime

www.biorxiv.org/content/10.1...

Great study by Landon J. Edgar and team demonstrating #sialicacid attentuates T cell death via Fas #glycotime

www.biorxiv.org/content/10.1...

Disrupting Siglec-mediated interactions to develop immunotherapies for cancer treatment Recent advances in cancer immunotherapy have improved patient outcomes, even in advanced stages of the disease. However, the effectiveness of current cancer immunotherapies remains limited to a sma...

#Siglec #SialicAcid #Glycotime

www.tandfonline.com/doi/full/10....

Targeting Sialidase to PD1 Enhances T cell Function and Tumor Control Immune therapies targeting the PD1 axis have transformed outcomes in cancer treatment by enhancing T cell-mediated immune responses. However, many tumors evade immune clearance through orthogonal esca...

🔥 HOT OFF THE PRESS 🔥

Today in ACS Central Science @pubs.acs.org , we report an anti-PD1 #sialidase conjugate that degrades #SialicAcid on PD1+ T cells, inflaming tumors and controlling their growth beyond SOC PD1 blockade in melanoma models #Glycotime

pubs.acs.org/doi/full/10....

An RNase III–processed sRNA coordinates sialic acid metabolism of Salmonella enterica during gut colonization | PNAS Sialic acids derived from colonic mucin glycans are crucial nutrients for enteric bacterial pathogens like Salmonella. The uptake and utilization o...

#sialicacid

Have the feeling this small RNA had been identified before in an hfq study, but didn’t cross-check yet.

FYI STM1128 is the Neu5Ac transporter SiaT, identified by, @gavinhthomas.bsky.social & others back in 2010 ;-)

www.pnas.org/doi/10.1073/...

Mutant glycosidases for labeling sialoglycans with high specificity and affinity - Nature Communications Highly specific glycan labels remain scarce, limiting their use in many applications. Here, authors report recombinant glycan affinity binders based on sialidase mutants, which are enzymatically inact...

#sialicacid

www.nature.com/articles/s41...

A Minimal Mutation Trajectory Separates Inverting and Retaining Mechanisms on the Same Sialidase Structural Scaffold The recently discovered sialidase AmGH181 from the human gut symbiont Akkermansia muciniphila is remarkably selective to the sialyl T-antigen, a glycan found on mucins and cancer cells. However, the m...

“…AmGH181 #sialidase from the human gut symbiont Akkermansia muciniphila is remarkably selective to the sialyl T-antigen…we show that specificity is governed by a flexible tryptophan–histidine pair…that precisely positions the sialyl T… for catalysis” #Siglec #SialicAcid #Glycotime

That’s all, folks!

Showing off some Paulson lab bling gifted to recent graduates! 🎓 ♦️ 💎

#Siglec #SialicAcid #Glycotime #PhD

Dear friends

I will defend my PhD Dissertaion on May15 at 14:00 PST.

Tune in to learn all about “Therpeutic Sialidase Conjugates Targeting the Glyco-Immune Axis in Cancer”.

(Link in the comments)

#Siglec #SialicAcid #Glycotime

Amazing to look on as #glycoRNA and related targeting strategies show major disease relevance! Congrats to the authors #Siglec #SialicAcid #Glycotime

Allosteric substrate release by a sialic acid TRAP transporter substrate binding protein - Communications Biology Biophysical and structural characterization of the TRAP transporter SBP SiaP in complex with a nanobody provides insights into an allosteric mechanism of inhibition.

www.nature.com/articles/s42...
#sialicacid #glycotime