Intra-patient #neuraminidase #mutations in avian #H5N1 #influenza virus reduce #sialidase activity to complement weaker hemagglutinin binding and facilitate #human infection

Intra-patient #neuraminidase #mutations in avian #H5N1 #influenza virus reduce #sialidase activity to complement weaker hemagglutinin binding and facilitate #human infection, etidiohnew.blogspot.com/2026/01/intr...

Targeting Sialidase to PD1 Enhances T cell Function and Tumor Control Immune therapies targeting the PD1 axis have transformed outcomes in cancer treatment by enhancing T cell-mediated immune responses. However, many tumors evade immune clearance through orthogonal esca...

🔥 HOT OFF THE PRESS 🔥

Today in ACS Central Science @pubs.acs.org , we report an anti-PD1 #sialidase conjugate that degrades #SialicAcid on PD1+ T cells, inflaming tumors and controlling their growth beyond SOC PD1 blockade in melanoma models #Glycotime

pubs.acs.org/doi/full/10....

A Minimal Mutation Trajectory Separates Inverting and Retaining Mechanisms on the Same Sialidase Structural Scaffold The recently discovered sialidase AmGH181 from the human gut symbiont Akkermansia muciniphila is remarkably selective to the sialyl T-antigen, a glycan found on mucins and cancer cells. However, the m...

“…AmGH181 #sialidase from the human gut symbiont Akkermansia muciniphila is remarkably selective to the sialyl T-antigen…we show that specificity is governed by a flexible tryptophan–histidine pair…that precisely positions the sialyl T… for catalysis” #Siglec #SialicAcid #Glycotime