A recent study reports SPYTACs (synthetic peptide-programmed lysosome-targeting chimeras), a fully synthetic, modular #eTPD platform that leverages LRP1-mediated endocytosis and transcytosis to cross the Blood-Brain Barrier (#BBB) and drive lysosomal degradation of extracellular Aβ.

🚀#SPYTACs enable efficient amyloid-β clearance in Alzheimer’s
Synthetic, modular #eTPD chimeras cross the #BBB (via LRP1) and drive lysosomal Aβ degradation.
In 5×FAD mice: ↓ Aβ, plaque targeting, improved cognition, fewer inflammation risks vs antibodies. Scalable to #Tau, PD-L1 & beyond.

#TargetedProteinDegradation #InducedProximity #MolecularGlue #TPD #eTPD #PROTAC #LYTAC #MoDEA #KineTAC #PROTAB #AbTAC #EpiTAC #REULR #GlueTAC #TICTAC #AUTAC #ATTEC #AUTOTAC #TrogoTAC #RIPR #RIPTAC #AgnoTAC #FragTAC #SHEDTAC