“Notice of Award” with Josh Gendron @Yale-sweetest word at this climate literally n figuratively #plantscience, #ASPB, #ECR, #proteostasis, #Arabidopsis

👉 Take-home:

𝔸𝕦𝕥𝕠𝕡𝕙𝕒𝕘𝕪 𝕚𝕤 𝕒 𝕤𝕡𝕒𝕥𝕚𝕒𝕝 𝕠𝕣𝕘𝕒𝕟𝕚𝕫𝕖𝕣 𝕠𝕗 𝕡𝕝𝕒𝕟𝕥 𝕚𝕞𝕞𝕦𝕟𝕚𝕥𝕪, coordinating entry, activation, and execution 🌱 #proteostasis ♻️ #theustunlab

We are now dissecting how it links
activation → execution at the PTI–ETI interface
(8/10)

Every step you take: How pathogens hijack host proteostasis from transcription, through translation, to degradation Proteostasis, the regulated balance between protein synthesis and degradation, is crucial for the cellular function and survival. Disruptions in this …

This resolves the paradox:

Autophagy doesn’t simply promote or suppress immunity —
it organizes where and how it works 🧠 #proteostasis pathways are not only pathogens targets (see also our latest review below👇) they influence cell-type specific immunity 😱

(6/10)

Preprint alert 🚨 (1/10) 🧵

𝘈𝘶𝘵𝘰𝘱𝘩𝘢𝘨𝘺 𝘪𝘴 𝘢 𝘱𝘢𝘳𝘢𝘥𝘰𝘹 𝘪𝘯 𝘱𝘭𝘢𝘯𝘵 𝘪𝘮𝘮𝘶𝘯𝘪𝘵𝘺:
It can promote resistance, susceptibility, or restrict cell death 🤯

So what is its actual role?

We show it acts as a spatial organizer of immunity across cell types 🌱🦠 #proteostasis

www.biorxiv.org/content/10.6...

New paper out in Protein Science!

We show that ligand binding in the substrate protein actively rewires Hsp90–cochaperone–client dynamics, steering protein fate rather than just stabilizing structures.

doi.org/10.1002/pro....

#ProteinScience #Proteostasis #Hsp90 #MolBio #CompBio

bims-proteo 2026-04-05 papers

Good morning! This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: Harnessing viral strategies to reverse cognitive dysfunction through the integrated stress response www.science.org/doi/10.1126/...

The ribosome-associated N-terminal acetyltransferase B coordinates global proteostasis and autophagy in plants by creating Ac/N-degrons - Nature Communications Protein N-terminal acetylation profoundly influences protein fate. Here, the authors establish NatB as a central regulator of the interplay between ubiquitin–proteasome system and autophagy, and highl...

Resistance to prolonged darkness in plants steered by N-terminal acetylation | New study by Gong et al. Markus Wirtz lab @giglionelab.bsky.social Tanja Bange lab #NatB #autophagy #N-degron #proteostasis www.nature.com/articles/s41...

Super interesting work! UFMylation moving up from a local ribosome repair signal to a systems-level coordinator of ER-nucleus #proteostasis

bims-proteo 2026-03-29 papers

Good morning!! This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: Systems-level organization of extracellular proteostasis www.science.org/doi/10.1126/...

Systems-level organization of extracellular proteostasis One defining feature of complex organisms is the ability to maintain protein homeostasis beyond cellular boundaries. We review how extracellular proteostasis is organized as a hierarchical network spa...

New in @science.org: our #ScienceReview explores how protein homeostasis is maintained beyond cellular boundaries proposing #extracellular #proteostasis as a hierarchical network spanning pericellular, tissue, and systemic tiers. With
Michele Vendruscolo 📄 Read here
www.science.org/doi/10.1126/...

a man in a lab coat is wearing sunglasses and a wig ALT: a man in a lab coat is wearing sunglasses and a wig

The feeling of getting super excited because you’re about to finish — and soon preprint — a paper you’ve been working with @shanshuo.bsky.social on for 5 years… indescribable 🥳. #preprint 🌱 #PlantScience #autophagy ♻️ #immunity #proteostasis #ERCStG #theustunlab

Interesting paper on the degradation of DELLAS (gibberellin pathway) by a plasma membrane localized E3 ubiquitin ligase to regulate growth under C/N imbalance #proteostasis
academic.oup.com/plcell/artic...

Such an exciting opportunity!
Be among the first to join the brand-new @leokiss.bsky.social lab @unidue.bsky.social 🧬✨
#CellularBiochemistry #Ubiquitin #Proteostasis #ProteinDegradation

Excited to decode the intricate language of ubiquitin chains and unravel their role in protein degradation? 🧬🔬
👉 APPLY NOW to join the lab of Dr. Leo Kiss @leokiss.bsky.social @imprs-lm.bsky.social.
#CellularBiochemistry #Ubiquitin #Proteostasis #ProteinDegradation

bims-proteo 2026-03-22 papers

Good morning! This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

Highlight: Hijacking ERAD for targeted degradation of transmembrane proteins www.cell.com/cell/abstrac...

#proteostasis #CookieParty!

Who wants some fantastic #proteostasis cookies (made by our bachelor student Nea)? So great to celebrate recent accepted papers in the group - hope we can continue celebrating our own little achievements 🤗 #theustunlab

Now our very own @manuelgonzalezfuen.bsky.social from @theustunlab.bsky.social who will talk about his exciting findings on how bacteria exploit P-body condensates to attenuate immune-related protein translation (see also our preprint below 👇) #MBP2026 #proteostasis

www.biorxiv.org/content/10.1...

Next talk is about one of my favorites - Ubiquitin: Cansu Dilege from @trujillolab.bsky.social lab will talk about „Lys63-ubiquitination“ by E2 Ligases #MBP2026 #proteostasis #plantscience

Excited to hear some #proteostasis research at #MBP2026 by @cnaumann123.bsky.social who talks about a new plant-specific component of the autophagic network - see also her latest preprint

www.biorxiv.org/content/10.6...

Interested in joining our team? Apply here! #Golgi #proteostasis

bims-proteo 2026-03-15 papers

Good morning! This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: ZAP targets aberrant mRNA transcripts encoding proteins with defective signal peptides for degradation link.springer.com/article/10.1...

The Üstün Lab Visit the post for more.

We just updated our lab homepage

„Plant #Proteostasis and its role in stress adaptation“

Check it out:

theustunlab.com

We had the pleasure of hosting @mariaermolaeva.bsky.social from the leibnizfli.bsky.social. Maria presented her research as part of our #FOR5762 seminar series. Her talk led to an engaging exchange of ideas and a lively discussion with the group.

#CircadianClock #Proteostasis #AgingResearch

🧬 Protein homeostasis aficionados:

⏰ Early-bird deadline: March 15 for our meeting this April.

We still have short talk slots available — great chance to share your work.

Apply now!

#proteostasis

bims-proteo 2026-03-08 papers

Hello! This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: The accessory adapters FAF1, FAF2, and UBXN7 accelerate proteasomal degradation by increasing prior p97-mediated substrate unfolding www.science.org/doi/10.1126/...

Registration now open for #EMBOUbiquitin.
meetings.embo.org/event/26-ubi...

Childcare, accessibility, and travel grants available.

#ubiquitin #TargetedProteinDegradation #Proteostasis #UBL

bims-proteo 2026-03-01 papers

Good morning! This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: Stress adaptation of mitochondrial protein import by OMA1-mediated degradation of DNAJC15 www.nature.com/articles/s41...

Congrats @plantophagy.bsky.social and team (and @gekaragoz.bsky.social too 🤩) great story!!!!
#proteostasis #RNAmetabolism

Kudos to the whole team and @tgalli.bsky.social -- 🙏 for allowing us to collaborate on this super exciting story -- I would also add #stress #organelles -- #ER_literature #proteostasis