Decoding m6A mRNA methylation by reader proteins in liver diseases

This review summarizes #m6A reader proteins in #LiverDisease, highlighting their roles in #RNAmetabolism, disease progression, & therapeutic potential, while emphasizing the promise of #SmallMoleculeInhibitors targeting reader–mRNA interactions.
#OpenAccess: doi.org/10.1016/j.ge...

This review highlights #m6A #RNAmodification as a regulator of #RNAmetabolism and cellular processes, linking aberrant m6A to #cancer, #obesity, diabetes, and cardiovascular disease, and exploring m6A-targeted therapies for #MetabolicDisorders.

#OpenAccess: doi.org/10.1016/j.ge...

Congrats @plantophagy.bsky.social and team (and @gekaragoz.bsky.social too 🤩) great story!!!!
#proteostasis #RNAmetabolism

BRAI2026 special discount offer

Meet with world-class speakers at the 6th #RNAMetabolism in Neurological Disease Conference. Mar 29–31, 2026 | San Diego, USA | Submit poster abstracts by Mar 16.
Special offer: Use code ACRNA100 to save $100 on the fee @rnasociety.bsky.social
Register now at spkl.io/63326AUr4g

This review examines the role of the #m6A writer #METTL16 in #cancer, detailing its m6A-dependent and independent regulation of #RNAmetabolism, links to #tumor growth, #metastasis and #DrugResistance, and its potential as a therapeutic target.

#OpenAccess: doi.org/10.1016/j.ge...

🌟G&D SPOTLIGHT 🌟

REVIEW: RNA granules: functional compartments or incidental condensates?
By Andrea Putnam, Laura Thomas and Geraldine Seydoux
➡️ https://genesdev.cshlp.org/content/37/9-10/354.abstract

#RNAmetabolism #RNAgranules #phaseseparation #RiboNucleoProteins #condensates

In typical cellular models (HEK293T), we observed that mRNA-1273 degradation is initiated via removal of the terminal pentamer (mΨCmΨAG), followed by #CCR4-NOT-mediated #deadenylation—the canonical #mRNA #decay pathway. (6/n) #RNAMetabolism