Single-cell exome sequencing reveals polyclonal seeding and TRPS1 mutations in colon cancer metastasis.
High-resolution insight into tumor evolution.
doi.org/10.1038/s413...
#ColonCancer #SingleCellSequencing #CancerGenomics #Metastasis #TRPS1 #TumorEvolution

ADAMTS Proteases: Their Multifaceted Role in the Regulation of Cancer Metastasis

Review by Rachele Bacchetti et al. on their roles in tumour microenvironment & cancer progression.

📌 PMCID: PMC7616120

dr.clintile.com/article/doi/...

#CancerResearch #TumourMicroenvironment #ECM #Metastasis

Researchers integrate transcriptomic, single‑cell, and #SpatialData to identify basement membrane‑associated genes driving #PDAC #metastasis, highlighting #ITGA3 as a therapeutic target, and proposing a novel gene signature for clinical intervention.
Read: doi.org/10.1016/j.ge...

💥 We made the COVER 🤩 of @natmater.nature.com !

CELL VISCOSITY 🎈 IN METASTATIC EXTRAVASATION

Check the entire issue here : lnkd.in/e9USS44n

@inserm.fr @unistra.fr

#zebrafish
#mouse
#metastasis
#mechanobiology
#imaging
#materials

Note : Image's credit is V.Gensbittel (PAA bead in a ZF ISV)

Esophageal cancer: treatment and risk of metastasis #esophagus #cancer #metastasis #esophagealcancer Esophageal cancer: treatment and risk of metastasis #esophagus #cancer #metastasis #esophagealcancer

Esophageal cancer: treatment and risk of metastasis #esophagus #cancer #metastasis #esophagealcancer ... Continue to: www.facebook.com/reel/1684610...

Treatment and risk of metastases in pleural cancer #pleuralcancer #pleural #metastasis #cancer
... Continue to: youtube.com/shorts/5RlGX...

¿Qué vuelve más agresivos a los tumores de cuerdas vocales? Un hallazgo clave revela cómo ciertos tumores de cuerdas vocales se vuelven más invasivos y por qué esa pista puede cambiar la oncología Un equipo del Ifom y de la Universidad de Milán ha identificado...

¿Qué vuelve más agresivos a los tumores de cuerdas vocales? #Cancer #Tumores #CuerdasVocales #Oncologia #Biotecnologia #Investigacion #Salud #Ciencia #Medicina #Metastasis #EGFR #Cx26 #felizmiercoles #1deabril donporque.com/que-empeora-...

🧬 COX-2 Block: Slows tumor growth.
🩸 Fewer platelets: Less spread.
📉 Studies: Lower colorectal risk.
⚠️ Drawback: More GI bleeding.
#AspirinAndCancer #TumorGrowth #Metastasis #ColorectalCancer #SideEffects
View in Timelines

Mitochondria-driven pseudohypoxic stabilization of #HIF1α via cyclophilin D suppression enhances #Melanoma #Metastasis via ROS-mediated signaling and EMT activation, identifying CypD restoration as a potent anti-metastatic therapeutic strategy.

#OpenAccess: doi.org/10.1038/s413...

TUG1 drives #chondrosarcoma progression by stabilizing EZH2 via ALYREF and promoting H3K27me3-mediated CPEB1 repression, while exosomal TUG1 enhances M2 #MacrophagePolarization, fueling #tumor growth and #metastasis.

#OpenAccess: doi.org/10.1016/j.ge...

🌅 #Research #Alert
Single-cell transcriptomics reveals #heterogeneity and #immune #microenvironment in lymphatic #metastasis of head and neck squamous cell #carcinoma

Access here: www.nature.com/articles/s41...
@springernature.com #Genes & #immunity

Treatment and risk of metastases in trachea, lung or bronchial cancer #metastasis #cancer #oncology
... Continue to: youtube.com/shorts/MofBX...

Descubren cómo el cáncer altera el cerebro y hace metástasis El CNIO revela cómo el cáncer secuestra defensas del cerebro para expandirse y sitúa a ibudilast como freno posible a la metástasis cerebral. El hallazgo del Centro Nacional de Investigaciones Oncológ...

Descubren cómo el cáncer altera el cerebro y hace metástasis #Cancer #Metastasis #MetastasisCerebral #CNIO #Investigacion #Salud #Cerebro #Oncologia #Ibudilast #LauraAlvaroEspinosa #ManuelValiente #FelizMiercoles #25deMarzo donporque.com/como-el-canc...

This review shows how #RNAbindingProteins and #circularRNAs form regulatory networks driving #tumor traits like #metastasis & #DrugResistance, offering therapeutic insights via RNA technologies to reshape the #TumorMicroenvironment.

#OpenAccess: doi.org/10.1016/j.ge...

Ageing promotes metastasis via activation of the integrated stress response - Nature Ageing reprograms the evolutionary trajectory of KRAS-driven lung adenocarcinoma, limiting primary tumour growth while promoting metastatic dissemination through epigenetic activation of the integrate...

This week #JournalClub @labsoap.bsky.social @nature.com #ageing #metastasis #stressresponse www.nature.com/articles/s41...

AI tool predicts cancer metastasis risk with high accuracy Researchers from the University of Geneva (UNIGE) have developed an artificial intelligence tool that can predict whether cancer will spread, providing about 80% accuracy. The tool, MangroveGS, uses gene patterns found in colon cancer cells to predict metastasis risk. By studying gene signatures and their interaction within cancer cells, the team was able to develop a model that works across multiple cancer types, including stomach, lung, and breast cancers. This breakthrough tool could transform how doctors assess metastasis risk and make treatment decisions, enabling more personalized and targeted care. The AI model analyzes tumor samples, sequences RNA, and generates a metastasis risk score that can be securely shared with doctors and patients. This innovation could reduce unnecessary treatments and side effects while ensuring that high-risk patients receive the appropriate care. Additionally, it offers potential to optimize clinical trial participant selection, improving the effectiveness of cancer treatments.

AI tool predicts cancer metastasis risk with high accuracy

🤖 IA: It's not clickbait ✅
👥 Usuarios: It's not clickbait ✅

#ai #cancer #metastasis

View full AI summary:

👋Our March issue is out!
Cover: #Adipose – #tumor in #immune escape

👉Reviews on: #metabolism #hematopoiesis ; #amnion ; #brain #lipids
🔬 #mitochondria #LipidDroplets #aging #autophagy #mechanobiology #neurodegeneration #ferroptosis #chromatin #metastasis & more!
www.nature.com/ncb/volumes/...

What stage is cancer typically in if it has spread to distant organs? A) Stage I B) Stage II C) Stag What stage is cancer typically in if it has spread to distant organs? A) Stage I B) Stage II C) Stag

What stage is cancer typically in if it has spread to distant organs?
A) Stage I
B) Stage II
C) Stage III
D) Stage IV
#cancerstages #oncology #metastasis #medicaleducation ... Continue to: www.facebook.com/113009240922...

Ageing promotes metastasis via activation of the integrated stress response - Nature Ageing reprograms the evolutionary trajectory of KRAS-driven lung adenocarcinoma, limiting primary tumour growth while promoting metastatic dissemination through epigenetic activation of the integrate...

#Ageing promotes #metastasis via activation of the integrated #stress response
doi.org/10.1038/s415...

Epigenetics Update - Ageing promotes metastasis via activation of the integrated stress response go.nature.com/4cGv6c7

Clotilde Wiel and Volkan I. Sayin reporting in Nature

#Epigenetics #Aging #Metastasis #Cancer
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Perfect for cancer, immunology, and aging research; epigenometech.com

Epigenetics Update - Paired patient-derived organoids reveal transcription factor-driven epigenetic remodeling in breast cancer metastasis bit.ly/4cSoZ4r

#Epigenetics #Organoids #BreastCancer #Metastasis #PDOs
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Gain deeper insights into gene regulation; epigenometech.com

This review highlights the role of #FattyAcidOxidation in #cancer, showing how mitochondrial regulation of energy and signaling drives #tumor growth and #metastasis, positioning FAO as a promising therapeutic target.

#OpenAccess: doi.org/10.1016/j.ge...

Key Genes Involved in the Beneficial Mechanism of Hyperbaric Oxygen for Glioblastoma and Predictive Indicators of Hyperbaric Oxygen Prolonging Survival in Glioblastoma Patients

This study shows that #HBOTherapy exerts #Antitumor effects in #Glioblastoma, promoting #Apoptosis, inhibiting #Inflammation, reducing #CellProliferation, suppressing #TumorGrowth & #Metastasis, regulating #Vascularization, & thus prolonging patient survival. #medsky

Read: doi.org/10.1007/s115...

Treatment and risk of metastases in trachea, lung or bronchial cancer #metastasis #cancer #oncology
... Continue to: youtube.com/shorts/MofBX...

Bladder cancer: treatment and risk of metastasis #bladder #bladdercancer #oncology #metastasis Bladder cancer: treatment and risk of metastasis #bladder #bladdercancer #oncology #metastasis

Bladder cancer: treatment and risk of metastasis #bladder #bladdercancer #oncology #metastasis ... Continue to: www.facebook.com/reel/1855406...

New AI Model Predicts Cancer Spread With Incredible Accuracy Scientists have developed an AI system that analyzes complex gene-expression signatures to estimate the likelihood that a tumor will spread.

New AI Model Predicts Cancer Spread with Incredible Accuracy | #cancer #metastasis #AI

Androgen Receptor Promotes Lung Cancer Metastasis by Modifying the miR23a-3p/EPHB2 Pathway

This study demonstrates that the AR promotes #LungCancer #Metastasis by modulating #miRNA 23a 3p/#EPHB2 signaling, suggesting that targeting this pathway could provide novel #therapeutic strategies to inhibit metastatic progression. #medsky

To read: doi.org/10.1007/s115...

Scientists reveal PKCη as a driver of #TNBC #metastasis by suppressing Hippo signaling & activating YAP, while a uORF-encoded peptide degrades PKCη, highlighting a novel therapeutic vulnerability in aggressive #BreastCancer.

#OpenAccess in #STTT: doi.org/10.1038/s413...

Important insight into #gastriccancer #metastasis. This study shows how #tumor-secreted Wnt ligands activate stromal fibroblasts to produce hyaluronan, creating a supportive metastatic niche in the #liver. www.linkedin.com/posts/drmelv...

Scientists show #CyclicdiGMP inhibits #breastcancer #metastasis by binding #PSMD3, disrupting PSMD3–TBK1 interaction, and suppressing NF‑κB signaling, positioning PSMD3 as a therapeutic target. #Antimetastatic @tulanemedicine.bsky.social

#OpenAccess #STTT: doi.org/10.1038/s413...