This review highlights the role of #FattyAcidOxidation in #cancer, showing how mitochondrial regulation of energy and signaling drives #tumor growth and #metastasis, positioning FAO as a promising therapeutic target.

#OpenAccess: doi.org/10.1016/j.ge...

Wee1-AS, a #lncRNA, protects against #MASLD by repressing #Wee1 and stabilizing #CYCLINB1 to activate CDK1-driven mitochondrial #FattyAcidOxidation, while WEE1 inhibition or the human homolog LNC106435.1 similarly improves mitochondrial function.

#STTT: doi.org/10.1038/s413...

The #lncRNA Wee1-AS regulates mitochondrial #FattyAcidOxidation and alleviates #MASLD via CDK1/CYCLIN B1 activation, with mouse and human homolog data supporting therapeutic potential and highlighting a targetable Wee1-AS/WEE1 metabolic axis.

#STTT: doi.org/10.1038/s413...

Higher #FattyAcidOxidation (likely +OXPHOS Adipogenesis mTPRC1) in non-failing ♀️Heart/Cardiomyocyte than ♂️heart

Integrative re-analysis of GTEx bulk RNAseq, snRNAseq, metabolomics

#CircAHA 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...

Emerging roles for fatty acid oxidation in cancer

This review summarizes recent advances and insights into the roles of #FattyAcidOxidation in tumorigenesis and tumor development, as well as its involvement in epigenetics, ferroptosis, the #TumorMicroenvironment, and immunotherapy. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Emerging roles for fatty acid oxidation in cancer

This review summarizes recent advances and insights into the roles of #FattyAcidOxidation in tumorigenesis and tumor development, as well as its involvement in epigenetics, ferroptosis, the #TumorMicroenvironment, and immunotherapy.

#OpenAccess: https://buff.ly/4h6YWVS

This review examines fatty acid oxidation's role in cancer metabolism, paving the way for new therapies. #CancerResearch #FattyAcidOxidation Details: www.sciencedirect.com/science/arti...

FOXO1-mediated lipid metabolism maintains mammalian embryos in dormancy - Nature Cell Biology van der Weijden et al. perform genomic, proteomic and metabolic analyses and find that FOXO1-mediated fatty acid oxidation maintains mouse embryos in diapause.

#NCB2024
In January, @bulutkarslioglu.bsky.social & co performed genomic, proteomic and metabolic analyses and found that FOXO1-mediated #FattyAcidOxidation maintains mouse #embryos in #diapause.
www.nature.com/articles/s41...

#FGF9 as a negative regulator of Hepatocyte Lipogenesis
#MASH

Adenoviral FGF9
⏬#HepaticSteatosis
⏫#GlucoseTolerance #InsulinSensivity
in🐭#DietInducedObesity

shFGF9 in liver
⏫ #FattyAcidSynthesis #FattyAcidTransport
⏬ #FattyAcidOxidation

#FrontPharmacol 2022
www.frontiersin.org/journals/pha...