Specialized post-arterial capillaries facilitate adult bone remodelling - Nature Cell Biology Mohanakrishnan et al. identify a distinct subset of post-arterial capillaries, termed type R. They show that type R capillaries contribute to trabecular bone formation in the diaphysis and respond to ...

Aaaaand finally:
#NCB2024
In November, @ralfhadams.bsky.social & co identified a distinct subset of post-arterial #capillaries, termed type R, which contribute to trabecular #bone formation in the diaphysis and respond to anti-#osteoporosis treatments.
www.nature.com/articles/s41...

Cell state transitions are decoupled from cell division during early embryo development Nature Cell Biology - Kukreja et al. show that blocking cell division in zebrafish does not affect differentiation of major cell types during gastrulation and segmentation, but it does decelerate...

#NCB2024
In November, Klein & co showed that blocking #CellDivision does not affect differentiation of major cell types during #gastrulation and segmentation.
rdcu.be/d5gI8
www.nature.com/articles/s41...

H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos Nature Cell Biology - Matsuwaka et al. show that JARID2-PRC2 initiates H3K27me2 deposition during the eight-cell-to-morula transition, following H2AK119 mono-ubiquitylation deposition. It is also...

#NCB2024
In October, Inoue & co showed that JARID2-#PRC2 initiates H3K27me2 deposition during the 8-cell-to-morula transition, following H2AK119 mono-ubiquitylation deposition; and it is required for H3K27me3 deposition at the #blastocyst stage.
rdcu.be/d491q
www.nature.com/articles/s41...

Ex vivo imaging reveals the spatiotemporal control of ovulation - Nature Cell Biology Thomas, Marx et al. devise a live imaging approach to spatiotemporally dissect mouse ovulation ex vivo.

#NCB2024
In October, Schuh & co devised a #LiveImaging approach to spatiotemporally dissect mouse #ovulation ex vivo.
www.nature.com/articles/s41...

Blood-generating heart-forming organoids recapitulate co-development of the human haematopoietic system and the embryonic heart - Nature Cell Biology Dardano et al. generate human pluripotent stem cell-derived cardiac organoids capable of undergoing endothelial-to-haematopoietic transition and producing haematopoietic cells.

#NCB2024
In October, Zweigerdt, Dardano, Drakhlis & co generated human pluripotent stem cell-derived #cardiac #organoids capable of undergoing endothelial-to-hematopoietic transition and producing #hematopoietic cells.
www.nature.com/articles/s41...

Recording morphogen signals reveals mechanisms underlying gastruloid symmetry breaking Nature Cell Biology - Toettcher, McNamara and colleagues use synthetic ‘signal-recording’ gene circuits on mouse gastruloids and find that cell sorting rearranges patchy domains of Wnt...

#NCB2024
In October, @toettch.bsky.social, McNamara & co reported that, in #gastruloids, cell sorting rearranges patchy domains of Wnt activity into a single pole, which defines the anterior–posterior axis.
rdcu.be/d4vk5
www.nature.com/articles/s41...

Inverse blebs operate as hydraulic pumps during mouse blastocyst formation Nature Cell Biology - Schliffka et al. show that in the early mouse embryo, hemispherical intrusions, or inverse blebs, grow into cells at cell–cell adhesion sites in response to luminal...

#NCB2024
In September, @maitrejl.bsky.social, Schliffka, Mukherjee & co showed that in the early mouse #embryo inverse blebs grow into cells at cell–cell adhesion sites in response to luminal fluid accumulation and pressure build-up.
rdcu.be/d4uCu
www.nature.com/articles/s41...

Retinoic acid induces human gastruloids with posterior embryo-like structures - Nature Cell Biology Hamazaki, Yang et al. report that an early pulse of retinoic acid robustly induces human gastruloids with a neural tube, segmented somites and more advanced cell types than conventional gastruloids.

#NCB2024
In August, @jshendure.bsky.social, Hamazaki & co reported that an early pulse of retinoic acid robustly induces human #gastruloids with a #NeuralTube, segmented #somites and more advanced cell types than conventional gastruloids.
www.nature.com/articles/s41...

Distinct dynamics of parental 5-hydroxymethylcytosine during human preimplantation development regulate early lineage gene expression - Nature Cell Biology Liang, Yan, Long, Ji et al. find that the origin and dynamics of 5-hydroxymethylcytosine (5hmC) during early development are not conserved between humans and mice and that 5hmC contributes to the acti...

#NCB2024
In July, Liang, Yan, Long, Ji et al. found that the origin and dynamics of 5-hydroxymethylcytosine (5hmC) during early development are not conserved between humans and mice and that 5hmC contributes to the activation of human embryonic genes.
www.nature.com/articles/s41...

A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing - Nature Cell Biology Werbowetski-Ogilvie, Taylor and colleagues report a noncanonical role for OTX2 in regulating alternative splicing and controlling a stem cell and pro-tumorigenic splicing program in group 3 medullobla...

#NCB2024
In July, @tamraogilvie.bsky.social, Taylor, @olivier-saulnier.bsky.social & co reported a noncanonical role for OTX2 in regulating #AlternativeSplicing and a stem cell and pro-tumorigenic splicing program in group 3 #medulloblastoma.
www.nature.com/articles/s41...

#NCB2024
In July, in 2 independent studies, Sun, Liu et al. and Sun et al. developed SPATAC-seq to map the #chromatin accessibility landscape of zebrafish #embryogenesis and mouse #organogenesis, respectively; they identified transcription regulators that determine cell fate.
👇

The maintenance of oocytes in the mammalian ovary involves extreme protein longevity - Nature Cell Biology Harasimov, Gorry, Welp, Penir, Horokhovskyi et al. analyse proteostasis in mammalian oocytes and ovaries: the maintenance of oocytes involves exceptional protein longevity, and many of the extremely l...

#NCB2024
In June, Schuh & co analyzed #proteostasis in mammalian #oocytes and ovaries: found that the maintenance of oocytes involves exceptional protein #longevity, and many of the extremely long-lived proteins decline as the ovary ages.
www.nature.com/articles/s41...

Extraembryonic gut endoderm cells undergo programmed cell death during development - Nature Cell Biology Batki, Hetzel et al. report a lineage-tracing strategy to track extraembryonic gut endoderm cells over development. They find that these cells are eventually eliminated in a p53-dependent manner and n...

#NCB2024
In June, Meissner & co reported a lineage-tracing strategy to track #extraembryonic gut #endoderm cells over development; showed these cells are eventually eliminated in a p53-dependent manner and neighboring embryonic cells clear their remnants.
www.nature.com/articles/s41...

Mapping putative enhancers in mouse oocytes and early embryos reveals TCF3/12 as key folliculogenesis regulators Nature Cell Biology - Liu, Xie and colleagues profile putative cis-regulatory elements in mouse oocytes and pre-implantation embryos. They further validate putative enhancers in oocytes and...

#NCB2024
In June, Liu, Xie & co profiled putative cis-regulatory elements in mouse #oocytes and pre-implantation #embryos. They further identified the transcription factors TCF3 and TCF12 as key regulators of #folliculogenesis.
rdcu.be/d3NiG
www.nature.com/articles/s41...

Cerebral organoids display dynamic clonal growth and tunable tissue replenishment - Nature Cell Biology Lindenhofer, Haendeler, Esk, Littleboy et al. perform whole-tissue lineage tracing in human cerebral organoids to reveal that a subpopulation of symmetrically dividing cells can adjust its lineage siz...

#NCB2024
In May, @knoblich-lab.bsky.social & co performed whole-tissue lineage tracing in human #cerebral #organoids to reveal that a subpopulation of symmetrically dividing cells can adjust its lineage size depending on tissue demands. #CellBio2024
www.nature.com/articles/s41...

CD32 captures committed haemogenic endothelial cells during human embryonic development - Nature Cell Biology Scarfò, Randolph et al. perform transcriptomic analysis of 28- to 32-day human embryos and identify CD32 as a marker of haemogenic endothelial cells (HECs), thus providing a strategy to isolate HECs f...

#NCB2024
In April, Ditadi & co performed transcriptomics on 28- to 32-day human embryos and identified CD32 as a marker of #hemogenic endothelial cells (HECs), thus providing a strategy to isolate HECs from human embryos and pluripotent stem cell cultures.
www.nature.com/articles/s41...

A cell fate decision map reveals abundant direct neurogenesis bypassing intermediate progenitors in the human developing neocortex - Nature Cell Biology Coquand, Brunet Avalos et al. develop an imaging method to map basal radial glial cell division in human fetal tissue and cerebral organoids and detect abundant symmetric amplifying, but also direct n...

#NCB2024
In March, Baffet & co developed an imaging method to map basal radial #glial cell division in human fetal tissue & #cerebral #organoids; they found abundant symmetric amplifying, but also direct neurogenic divisions bypassing intermediate progenitors.
www.nature.com/articles/s41...

Competence for neural crest induction is controlled by hydrostatic pressure through Yap - Nature Cell Biology Alasaadi et al. report the role of hydrostatic pressure in regulating embryonic competence in the developing neural crest.

#NCB2024
In March, @mayorlab.bsky.social & co reported the role of #hydrostatic pressure in regulating embryonic competence in the developing #neural crest.
www.nature.com/articles/s41...

Distinct pathways drive anterior hypoblast specification in the implanting human embryo - Nature Cell Biology Weatherbee, Weberling, Gantner et al. find contrasting requirements for BMP in the anterior signalling centre and pre-implantation epiblast between mice and humans. They further find that NOTCH may be...

#NCB2024
In March, @zernickagoetz.bsky.social & co found contrasting requirements for BMP in the anterior signaling center and pre-implantation #epiblast between mice and humans; and that NOTCH may be indispensable for human epiblast survival.
www.nature.com/articles/s41...

Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains Nature Cell Biology - Zwick et al. examine longitudinal transcriptional patterns across the entire mouse and human small intestine and find that, in both species, the small intestine comprises five...

#NCB2024
In February, @ophirklein.bsky.social & co examined transcriptional patterns across the entire mouse and human small #intestine and found that it comprises five domains of #NutrientAbsorption and three regional #StemCell populations.
rdcu.be/d2FlY
www.nature.com/articles/s41...

Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture - Nature Cell Biology Villeneuve et al. report coordination of contractile forces during mammalian hair follicle development, with actomyosin contractility and mechanical forces from the epidermis and underlying tissue reg...

#NCB2024
In February, Villeneuve et al. reported coordination of contractile forces during mammalian hair follicle development.
www.nature.com/articles/s41...

Low-input lipidomics reveals lipid metabolism remodelling during early mammalian embryo development Nature Cell Biology - Using low-input lipidomics in mouse and human embryos, Zhang, Shui, Li and colleagues find that lipid unsaturation increases with development towards the blastocyst stage....

#NCB2024
In February, with low-input #lipidomics in mouse & human #embryos, Zhang et al found that lipid unsaturation increases with development towards the #blastocyst; and that lipid desaturases contribute to embryo implantation.
rdcu.be/d2nuA
www.nature.com/articles/s41...

Single-cell multi-omics profiling of human preimplantation embryos identifies cytoskeletal defects during embryonic arrest Nature Cell Biology - Lin Li, Lei Li et al. perform single-cell multi-omics to study the transcriptome, the DNA methylome and chromatin accessibility in human arrested embryos and find that...

#NCB2024
In January, Lin Li, Lei Li et al. did single-cell #multiomics to study human arrested #embryos and found that cytoskeletal defects cause embryonic arrest characterized by #ZygoticGenomeActivation.
rdcu.be/d2g1j
www.nature.com/articles/s41...

Single-cell spatial multi-omics and deep learning dissect enhancer-driven gene regulatory networks in liver zonation - Nature Cell Biology Bravo González-Blas et al. uncover enhancer-gene regulatory networks underlying hepatocyte identity and their zonation state by combining single-cell and spatial multiomics with massively parallel rep...

#NCB2024
In January, @steinaerts.bsky.social & co uncovered enhancer-gene regulatory networks underlying #hepatocyte identity and their zonation state by combining single-cell and spatial #multiomics with massively parallel reporter assays and deep learning.
www.nature.com/articles/s41...

FOXO1-mediated lipid metabolism maintains mammalian embryos in dormancy - Nature Cell Biology van der Weijden et al. perform genomic, proteomic and metabolic analyses and find that FOXO1-mediated fatty acid oxidation maintains mouse embryos in diapause.

#NCB2024
In January, @bulutkarslioglu.bsky.social & co performed genomic, proteomic and metabolic analyses and found that FOXO1-mediated #FattyAcidOxidation maintains mouse #embryos in #diapause.
www.nature.com/articles/s41...

Tomorrow is my 3-year anniversary as an editor at @naturecellbiology.bsky.social. Lots to celebrate and enjoy, but most importantly #NCB2024 will commence! See below, if you ‘re not familiar, and stay tuned!
#science #cellbiology #stemcells #developmentalbiology

It's been a tradition since I started my editorial career. We had our #NCB2022, #NCB2023; and ofc there 'll also be #NCB2024: I 'll be counting down to the end of 2024, recapping #stemcell/#devbio studies we published at Nature Cell Biology in 2024. Stay tuned!