It was a tough #poster design session last night! 😆

Next week I'll be at the @embo.org "Structure and function of the cytoskeleton" #meeting in #Paris, where I'll discuss the actin-dependent regulation our favorite #super-organelles in #oocytes.

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Stem Cell Regenera: A Regenerative Approach to Activating Dormant Ovarian Follicles - Aging-US Research A new study published recently in Aging (Aging-US) Volume 17, Issue 6, examines a novel treatment for women with ovarian failure. Researchers from IVI Clinics Alicante in Spain investigated a procedur...

✅ Read our recent #blog post, titled "Stem Cell Regenera: A Regenerative Approach to Activating Dormant Ovarian Follicles."

🔗 aging-us.org/2025/07/stem...

#aging #TrendingWithImpact #summary #ovarianfailure #oocytes #research #openaccess #peerreviewed #journal #publishing

A warm welcome to Roni, who joined the Schuh lab in December 2025 as a new Postdoc! She completed her PhD in Genetics focusing on the development and aging of #oocytes in C. elegans.
Now she‘ll investigate the role of actin in #meiosis.
Great to have you with us, Roni 🎉

#oocytes
❤️🥚❤️

Stem Cell Regenera: A Regenerative Approach to Activating Dormant Ovarian Follicles - Aging-US Research A new study published recently in Aging (Aging-US) Volume 17, Issue 6, examines a novel treatment for women with ovarian failure. Researchers from IVI Clinics Alicante in Spain investigated a procedur...

✅ Read our recent #blog post, titled "Stem Cell Regenera: A Regenerative Approach to Activating Dormant Ovarian Follicles."

🔗 aging-us.org/2025/07/stem...

#aging #TrendingWithImpact #summary #ovarianfailure #oocytes #research #openaccess #peerreviewed #journal #publishing

Stem Cell Regenera: A Regenerative Approach to Activating Dormant Ovarian Follicles - Aging-US Research A new study published recently in Aging (Aging-US) Volume 17, Issue 6, examines a novel treatment for women with ovarian failure. Researchers from IVI Clinics Alicante in Spain investigated a procedur...

✅ Read our recent #blog post, titled "Stem Cell Regenera: A Regenerative Approach to Activating Dormant Ovarian Follicles."

🔗 aging-us.org/2025/07/stem...

#aging #TrendingWithImpact #summary #ovarianfailure #oocytes #research #openaccess #peerreviewed #journal #publishing

🧫 Intracytoplasmic sperm injection (ICSI)  has been widely used in assisted reproduction for #malefactor #infertility but this technique can place significant mechanical stress on #oocytes, sometimes leading to degeneration and reduced #embryo quality.

This week, we cover the latest work from Gameto!

Their Fertilo platform improved the in vitro maturation of human #oocytes. 🥚

Article: https://bit.ly/4sSEmPN
Discussion: https://bit.ly/3ZjiWxM

The #cellbio2025 is starting this week! I’ll be giving a talk on the first 1st day, in the session organized by @iaincheeseman.bsky.social and @abbybuch.bsky.social (Thx for the invitation!). If you’re interested in #oocytes, #proteostasis, and #aging come by to attend! @ascbiology.bsky.social

Designing protein-based artificial kinetochores as decoys to prevent meiotic errors in oocytes - Nature Cell Biology Zhou et al. design protein-based artificial kinetochore constructs as decoys to prevent premature chromosomal separation in aged oocytes. These constructs compete with chromosomal kinetochores, reduci...

☕Zhou et al. design protein-based artificial #kinetochore constructs as decoys to prevent premature #chromosomal separation in aged #oocytes. These constructs compete with chromosomal kinetochores, reducing excessive bipolar #microtubule pulling forces.
bit.ly/48g0oTa

🥚As proof of concept, #oocytes were successfully collected from six euthanised koalas within two hours post-mortem, showing potential for the development of #genomebanks to support the species’ recovery.

#koalaconservation #reproductivebiology 
#genomebanking

🧬Why does female fertility decline with age? And can egg cells be rejuvenated🥚?
Find out in a new interview with Melina discussing her research on the biology of aging #oocytes.
#WomensHealth 💜
(Article in German)
ajour.ch/de/story/634...

Designing protein-based artificial kinetochores as decoys to prevent meiotic errors in oocytes - Nature Cell Biology Zhou et al. design protein-based artificial kinetochore constructs as decoys to prevent premature chromosomal separation in aged oocytes. These constructs compete with chromosomal kinetochores, reduci...

Team led by Tomoya Kitajima designed protein-based artificial #kinetochores to act as decoys to reduce bipolar microtubule pulling forces on chromosomes in aged mouse #oocytes, preventing premature #ChromosomeSegregation during meiosis I & II.
In @natcellbio.nature.com
👇
doi.org/10.1038/s415...

In @jcb.org, Avilov, @plenart.bsky.social et al. @maxplanck.de used quantitative phosphoproteomics in #starfish #oocytes to identify downstream targets of the conserved Mos–MAPK pathway. rupress.org/jcb/article/...

#Cytoskeleton #CellCycle #CellDivision #Physiology

Avilov, @plenart.bsky.social et al. @maxplanck.de used quantitative phosphoproteomics in #starfish #oocytes to identify downstream targets of the conserved Mos–MAPK pathway. rupress.org/jcb/article/...

#Cytoskeleton #CellCycle #CellDivision #Physiology

Stem Cell Regenera: A Regenerative Approach to Activating Dormant Ovarian Follicles - Aging (Aging-US) Research A new study published recently in Aging (Aging-US) Volume 17, Issue 6, examines a novel treatment for women with ovarian failure. Researchers from IVI Clinics Alicante in Spain investigated a procedur...

✅ Read our recent #blog post, titled "Stem Cell Regenera: A Regenerative Approach to Activating Dormant Ovarian Follicles."

🔗 aging-us.org/2025/07/stem...

#aging #TrendingWithImpact #summary #ovarianfailure #oocytes #research #openaccess #peerreviewed #journal #publishing

How egg cells control the timing of cell division RIKEN researchers have found that MPS1 promotes timely spindle bipolarization, preventing kinetochore–microtubule attachment errors in oocytes.

📃Read a #ResearchHighlight on a study led by Shuhei Yoshida & Tomoya Kitajima (Lab for Chromosome Segregation) in which they find MPS1 proteins play a key role to ensure spindle bipolarization occurs before #kinetochores attach to microtubles in #oocytes during #meiosis.
www.riken.jp/en/news_pubs...

Direct reprogramming of skin cells into functional oocytes: a potential infertility treatment – BioNews Central Researchers have demonstrated a proof of concept for treating infertility by converting skin cells into oocytes capable of producing early human embryos. ...

Researchers have demonstrated a #ProofOfConcept for treating #infertility by converting #SkinCells into #oocytes capable of producing early #HumanEmbryos. 
#InfertilityTreatment

Stem Cell Regenera: A Regenerative Approach to Activating Dormant Ovarian Follicles - Aging (Aging-US) Research A new study published recently in Aging (Aging-US) Volume 17, Issue 6, examines a novel treatment for women with ovarian failure. Researchers from IVI Clinics Alicante in Spain investigated a procedur...

✅ Read our recent #blog post, titled "Stem Cell Regenera: A Regenerative Approach to Activating Dormant Ovarian Follicles."

🔗 aging-us.org/2025/07/stem...

#aging #TrendingWithImpact #summary #ovarianfailure #oocytes #research #openaccess #peerreviewed #journal #publishing

Vibrating Human Eggs Clean For IVF. Biologists at Cornell University with a microfluidic chip through which eggs can pass and be cleansed of cumulus cells with vibration-induced flow. #oocytes #cumulus #ivf #icsi #microchip #cleansing

Stem Cell Regenera: A Regenerative Approach to Activating Dormant Ovarian Follicles - Aging (Aging-US) Research A new study published recently in Aging (Aging-US) Volume 17, Issue 6, examines a novel treatment for women with ovarian failure. Researchers from IVI Clinics Alicante in Spain investigated a procedur...

✅ Read our recent #blog post, titled "Stem Cell Regenera: A Regenerative Approach to Activating Dormant Ovarian Follicles."

🔗 aging-us.org/2025/07/stem...

#aging #TrendingWithImpact #summary #ovarianfailure #oocytes #research #openaccess #peerreviewed #journal #publishing

Eliminating both #separase inhibition mechanisms –via securin and via cyclin B1-Cdk1– reveals absence of robust cohesin protection in metaphase II #oocytes
Katja Wassmann @meiosis-mom.bsky.social and colleagues
www.embopress.org/doi/full/10....

Stem Cell Regenera: A Regenerative Approach to Activating Dormant Ovarian Follicles - Aging (Aging-US) Research A new study published recently in Aging (Aging-US) Volume 17, Issue 6, examines a novel treatment for women with ovarian failure. Researchers from IVI Clinics Alicante in Spain investigated a procedur...

✅ Read our recent #blog post, titled "Stem Cell Regenera: A Regenerative Approach to Activating Dormant Ovarian Follicles."

🔗 aging-us.org/2025/07/stem...

#aging #TrendingWithImpact #summary #ovarianfailure #oocytes #research #openaccess #peerreviewed #journal #publishing

Online now - the Feature Review "#Proteostasis in cellular dormancy: lessons from yeast to oocytes" from Stephanie Rosswag, @bokelab.bsky.social‬, and @gzaffagnini.bsky.social.

#quiescence #yeast #oocytes #stemcells #embryonicdiapause #CancerCells

authors.elsevier.com/sd/article/S...

Many congratulations to Jurgita on receiving the prestigious HFSP Postdoctoral Fellowship for her groundbreaking project on protein storage in mammalian #oocytes. Jurgita, we are so proud of you for this well-deserved recognition! Stay tuned to follow her exciting research journey! 🏆🌟

In-cell NMR spectroscopy of nucleic acids: Basic concepts, practical aspects, and applications In-cell NMR spectroscopy has recently emerged as a unique source of atomically resolved information on the structure, dynamics, and interactions of nu…

🚨 Paper Alert! 🚨 Did you know that frog oocytes can be used to study human telomerase DNA sequences? 🧬🐸 If not, check out our latest study! 🔬📖 #Xenopus #oocytes #NMR #DNA #quadruplexes

www.sciencedirect.com/science/arti...

The Balbiani body is formed by microtubule-controlled molecular condensation of Buc in early oogenesis Kar et al. demonstrate that Balbiani body (Bb) formation is achieved via developmental condensation in zebrafish oogenesis, driven by Buc phase separation and evolving from a dynamic liquid-like state into a solid-like stable compartment. Multistep regulation by microtubules controls condensation, ensuring proper Bb formation and oocyte polarity.

💥Finally out!
Answering a two-centuries old question about a membraneless organelle that forms in #oocytes from insects to humans: the Balbiani body (Bb).
Now in
@currentbiology.bsky.social
:
cell.com/current-biol...
>

This is couple of years old since I rarely have time to sit at a scope these days but I was inspired by the end of year #FluorescenceFriday posts on hear and thought I should drop on y’all my Eye of Sauron, aka a mouse oocyte containing nuclear actin filaments #actin #meiosis #oocytes

The maintenance of oocytes in the mammalian ovary involves extreme protein longevity - Nature Cell Biology Harasimov, Gorry, Welp, Penir, Horokhovskyi et al. analyse proteostasis in mammalian oocytes and ovaries: the maintenance of oocytes involves exceptional protein longevity, and many of the extremely l...

#NCB2024
In June, Schuh & co analyzed #proteostasis in mammalian #oocytes and ovaries: found that the maintenance of oocytes involves exceptional protein #longevity, and many of the extremely long-lived proteins decline as the ovary ages.
www.nature.com/articles/s41...

Mapping putative enhancers in mouse oocytes and early embryos reveals TCF3/12 as key folliculogenesis regulators Nature Cell Biology - Liu, Xie and colleagues profile putative cis-regulatory elements in mouse oocytes and pre-implantation embryos. They further validate putative enhancers in oocytes and...

#NCB2024
In June, Liu, Xie & co profiled putative cis-regulatory elements in mouse #oocytes and pre-implantation #embryos. They further identified the transcription factors TCF3 and TCF12 as key regulators of #folliculogenesis.
rdcu.be/d3NiG
www.nature.com/articles/s41...