Read about a study led by BDR's Tomoya Kitajima showing that a protein-based artificial #kinetochore they developed can serve as decoys to relieve pulling forces acting on #chromosome pairs in dividing aged mouse #oocytes to prevent premature segregation.
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www.riken.jp/en/news_pubs...
☕Zhou et al. design protein-based artificial #kinetochore constructs as decoys to prevent premature #chromosomal separation in aged #oocytes. These constructs compete with chromosomal kinetochores, reducing excessive bipolar #microtubule pulling forces.
bit.ly/48g0oTa
Alves Domingos, Green, Cheerambathur et al. reveal that the #kinetochore protein KNL-1 regulates the #actin #cytoskeleton to control dendrite branching. rupress.org/jcb/article/...
📕 In Cellular Neurobiology collection: rupress.org/jcb/collecti...
#SfN25
New publication from Dr. @dipesh-lab.bsky.social in collaboration with Prof. @raphmercier.bsky.social from @mpipz.bsky.social in @commsbio.nature.com Journal on Kinetochore KMN complex.
Read the paper for more: www.nature.com/articles/s42...
#Kinetochore #KMNcomplex #arabidopsis
Ines Anna Drinnenberg @institutcurie.bsky.social @sorbonne-universite.fr and co-workers @nordicembl.bsky.social show that #insects evolved a conserved monomeric #histone fold domain in the CENP-T #kinetochore protein family. #evolution
-> www.embopress.org/doi/full/10....
@vcmentowski.bsky.social & @andrea-musacchio.bsky.social have solved the mystery surrounding the ‘crown’ of #celldivision . They showed how the #kinetochore #corona is constructed and how this guarantees the error-free distribution of #chromosomes
www.mpi-dortmund.mpg.de/news/crown-o...
Dual Pathways Assemble the Kinetochore Corona in Cell Division
Scientists show the kinetochore corona is seeded by BUB1 and BUBR1 and expands via two pathways – structural scaffolding and regulatory linking, as reported in Science Advances. getnews.me/dual-pathways-assemble-t... #kinetochore #celldivision
Stu2 performs an essential #kinetochore function independent of its #microtubule polymerase activity, say Ahmed Abouelghar, Joseph Carrier, Matthew Miller @mpmiller.bsky.social and colleagues @utah.edu: rupress.org/jcb/article/...
#CellDivision #Cytoskeleton #Biochemistry #Genetics
Abouelghar, Carrier, @mpmiller.bsky.social et al. @utah.edu show that budding yeast Stu2’s #kinetochore function is essential for cell viability. Surprisingly, this function is independent of its canonical ability to induce #microtubule assembly and disassembly. rupress.org/jcb/article/...
In @jcb.org, Abouelghar, Carrier, @mpmiller.bsky.social et al. show that budding yeast Stu2’s #kinetochore function is essential for cell viability. Surprisingly, this function is independent of its canonical ability to induce #microtubule assembly and disassembly. rupress.org/jcb/article/...
Our results support the idea that Csm1-like proteins may contribute to conserved kinetochore functions across eukaryotes.
Pre-proof out now in iScience!
🔗 doi.org/10.1016/j.is...
#Arabidopsis #Kinetochore #PlantBiology #meiosis4eva
How does natural compound #parthenolide exert its #antimitotic activity?
Marin Barisic and coworkers @barisiclab.bsky.social find it not to target microtubules, but to instead modify #kinetochore protein BUGZ to prevent spindle attachment and chromosome congression
www.embopress.org/doi/full/10....
Stefan Westermann and collaborators reveal a new essential recruitment mechanism of Aurora kinase Ipl1 to the outer #kinetochore during chromosome biorientation:, via an interaction between Sli15 and Spc105/Kre28
www.embopress.org/doi/full/10....
a complicated figure summarizing results of the linked paper
New #ISEPpaper! On the possibility of yet a third #kinetochore system in the protist phylum Euglenozoa journals.asm.org/doi/full/10.... by Corinna Benz et al.
#Protists #Microbes #Evolution #CellBiology
Interactions with multiple inner #kinetochore proteins determine mitotic localization of FACT, say Julia Schweighofer, Bhagyashree Mulay, Andrea Musacchio (@andrea-musacchio.bsky.social) and colleagues: rupress.org/jcb/article/...
#Mitosis
Schweighofer, Mulay, @andrea-musacchio.bsky.social et al. reconstitute direct interactions between FAcilitates Chromatin Transcription and the 16-subunit constitutive centromere–associated network core of the chromatin-proximal #kinetochore rupress.org/jcb/article/...
#mitosis
In our new preprint: biorxiv.org/content/10.1... we find that the tilted stalk of the NDC80 complex—a crucial component of the kinetochore—may be responsible for its asymmetric grip on microtubules. This conclusion may also extend to other MAPs. #Microtubule #Biophysics #Kinetochore
Spotlight: Hannes Bülow discusses a study by Alves Domingos et al. from the Dhanya Cheerambathur's lab (https://buff.ly/3EaEvco which reveals that a #kinetochore protein surprisingly regulates dendrite branching by modulating F-#actin dynamics. https://buff.ly/4hjZgAK
The essential N-terminal domain (END) of yeast CENP-A homolog Cse4 stabilizes its localization at #centromeres via binding to #kinetochore proteins Okp1 and Ame1
@suebiggins.bsky.social sky.social and collaborators @hutchbasicsci.bsky.social @fredhutch.bsky.social
www.embopress.org/doi/full/10....
Open Access: #Humanization reveals pervasive incompatibility of #yeast and #human #kinetochore components
G3 | January 2024 | Vol. 14, Iss. 1
Guðjón Ólafsson, Max A.B. Haase, Jef D. Boeke
community.alliancegenome.org/t/open-acces...
Targeting conserved regions of #kinetochore proteins KNL1 and NDC80 provides antibodies for labeling #centromeres across a spectrum of seed plants ! Great collaboration led my the Macas lab www.biorxiv.org/content/10.1...
