Opening of our JEOL Cryo-ARM 200, 2 April 2026 :-)
Don't hesitate to get in touch with us if you want nice cryo-EM and/or cryo-ET data !
biosit.univ-rennes.fr/en/tem2c
#cryo-EM #microtubule
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Hashtag
#Microtubule
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OptoTAT reveals #microtubule acetylation as a rapid trigger for GEF-H1–mediated cell migration. New tool developed by Abhijit Deb Roy, Takanari Inoue @jhu.edu and colleagues:
rupress.org/jcb/article/...
#Cytoskeleton #Technology #Optogenetics
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In @jcb.org, Deb Roy, Inoue et al. @jhu.edu introduce an #optogenetics tool to rapidly induce #microtubule acetylation in living cells and show that this triggers release of the RhoGEF GEF-H1 from #microtubules, thereby driving persistent directional cell migration. rupress.org/jcb/article/...
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Deb Roy, Inoue et al. @jhu.edu introduce an #optogenetics tool to rapidly induce #microtubule acetylation in living cells and show that this triggers release of the RhoGEF GEF-H1 from #microtubules, thereby driving persistent directional cell migration. rupress.org/jcb/article/...
#Cytoskeleton
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A cryo-EM processing pipeline for microtubules using CryoSPARC
www.biorxiv.org/content/10.6...
#CryoEM, #microtubule
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Shu et al. found that downregulation of #microtubule proteins TUBB2A, TUBB3, and TUBB4B contributes to #neuronaldysfunction in #Alzheimer’s disease by impairing microtubule stability and promoting tau pathology. doi.org/10.4103/AGIN... #Tubulin #Neuroscience #Bioinformatics #ADresearch #Aging
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Identification of a cytosol to nucleus feedback loop that regulates neuronal #microtubule nucleation. New study from Nitish Kumar, Melissa M. Rolls and colleagues (Pennsylvania State University): rupress.org/jcb/article/...
#Neuroscience #Cytoskeleton
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Using #Drosophila neurons, Nitish Kumar, Melissa Rolls et al. identify a pathway that communicates changes in #microtubule dynamics to the #nucleus. This pathway in turn modulates the expression of γTubulin, the central microtubule nucleator. rupress.org/jcb/article/...
#Cytoskeleton #Neuroscience
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In @jcb.org: Using #Drosophila neurons, Nitish Kumar, Melissa Rolls et al. identify a pathway that communicates changes in #microtubule dynamics to the #nucleus. This pathway in turn modulates the expression of γTubulin, the central microtubule nucleator. rupress.org/jcb/article/...
#Neuroscience
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New study from Chou, McCartney et al. @cmu.edu demonstrates coregulation of #actin filament assembly/bundling and #microtubule nucleation/organization during #Drosophila #oogenesis, highlighting the coordinated regulation of the #cytoskeleton required during #development. rupress.org/jcb/article/...
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In @jcb.org, Chou, McCartney et al. @cmu.edu demonstrate coregulation of #actin filament assembly/bundling and #microtubule nucleation/organization during #Drosophila #oogenesis, highlighting the coordinated regulation of the #cytoskeleton required during #development. rupress.org/jcb/article/...
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Bored over the holidays? Give our new preprint on how #microtubule lattice alteration by taxols can regulate #RhoA #signalling via GEF-H1 a read!
Perhaps a new mechanism of action for taxol #chemotherapeutics during interphase.
www.biorxiv.org/content/10.6...
Happy holidays ✨🎄
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New from the Mizuno Lab, with help from IPI’s Nirakar Basnet: insights into how #microtubule shoots stabilize and repair #axons — and how epothilone B drives CNS regeneration. Read it in Nature: buff.ly/lO9xwIX
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Happy #MicroscopyMonday from our brilliant team recently at #CellBio25 Booth no. 416!
#scienceconference #sciencetravel #sciencecollaboration #labhelp #scienceconnections #nanobodies #livecellimaging #mitochondria #lysosome #microtubule #fixedcells #cellularimaging #microscopy
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Top left: Slbo in the outer border cell non- cell autonomously regulates JNK signaling to maintain the proper apical–basal polarity of the migrating border cell cluster. The proper polarity of the border cell cluster facilitates the formation of the polar cell protrusion at stage 13. Bottom left: After formation of the polar cell protrusion, JNK signaling in the polar cell regulates the movement of lysosomal components towards the oocyte through the nanotube. is deposited at the tip of the protrusion which aids to open the vitelline envelope for sperm entry during fertilization. Right: High-resolution 2D STED imaging (30 nm XY resolution) of a Stage 13 Drosophila egg chamber reveals lysosomal dynamics within a polar-cell nanotube. The polar-cell protrusion is labelled with Fas III (Magenta), nuclei are stained with DAPI (Blue), and lysosomal compartments are visualized using LAMP1-eGFP (Green), which are enriched at the apical side of the polar cell and are also present within the protrusion, indicating active trafficking through the nanotube. Images were acquired with a 60× objective on an ABBERIOR 3D-STED Facility Line microscope.
Membrane #nanotubes are cytoskeletal structures that facilitate intercellular communication. This study shows that polar cell-derived #microtubule nanotubes play a role in #Drosophila #fertilization, creating a channel in the eggshell that facilitates #sperm entry @plosbiology.org 🧪 plos.io/3XwOlvS
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Top left: Slbo in the outer border cell non- cell autonomously regulates JNK signaling to maintain the proper apical–basal polarity of the migrating border cell cluster. The proper polarity of the border cell cluster facilitates the formation of the polar cell protrusion at stage 13. Bottom left: After formation of the polar cell protrusion, JNK signaling in the polar cell regulates the movement of lysosomal components towards the oocyte through the nanotube. is deposited at the tip of the protrusion which aids to open the vitelline envelope for sperm entry during fertilization. Right: High-resolution 2D STED imaging (30 nm XY resolution) of a Stage 13 Drosophila egg chamber reveals lysosomal dynamics within a polar-cell nanotube. The polar-cell protrusion is labelled with Fas III (Magenta), nuclei are stained with DAPI (Blue), and lysosomal compartments are visualized using LAMP1-eGFP (Green), which are enriched at the apical side of the polar cell and are also present within the protrusion, indicating active trafficking through the nanotube. Images were acquired with a 60× objective on an ABBERIOR 3D-STED Facility Line microscope.
Membrane #nanotubes are cytoskeletal structures that facilitate intercellular communication. This study shows that polar cell-derived #microtubule nanotubes play a role in #Drosophila #fertilization, creating a channel in the eggshell that facilitates #sperm entry @plosbiology.org 🧪 plos.io/3XwOlvS
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Top left: Slbo in the outer border cell non- cell autonomously regulates JNK signaling to maintain the proper apical–basal polarity of the migrating border cell cluster. The proper polarity of the border cell cluster facilitates the formation of the polar cell protrusion at stage 13. Bottom left: After formation of the polar cell protrusion, JNK signaling in the polar cell regulates the movement of lysosomal components towards the oocyte through the nanotube. is deposited at the tip of the protrusion which aids to open the vitelline envelope for sperm entry during fertilization. Right: High-resolution 2D STED imaging (30 nm XY resolution) of a Stage 13 Drosophila egg chamber reveals lysosomal dynamics within a polar-cell nanotube. The polar-cell protrusion is labelled with Fas III (Magenta), nuclei are stained with DAPI (Blue), and lysosomal compartments are visualized using LAMP1-eGFP (Green), which are enriched at the apical side of the polar cell and are also present within the protrusion, indicating active trafficking through the nanotube. Images were acquired with a 60× objective on an ABBERIOR 3D-STED Facility Line microscope.
Membrane #nanotubes are cytoskeletal structures that facilitate intercellular communication. This study shows that polar cell-derived #microtubule nanotubes play a role in #Drosophila #fertilization, creating a channel in the eggshell that facilitates #sperm entry @plosbiology.org 🧪 plos.io/3XwOlvS
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#Plant #CYTOSKELETON fans, we have a great #openaccess #research #article for you! Arabidopsis AUGMIN8 Contains Two Independent #Microtubule Association Domains. Check it out here: onlinelibrary.wiley.com/doi/full/10....
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☕Zhou et al. design protein-based artificial #kinetochore constructs as decoys to prevent premature #chromosomal separation in aged #oocytes. These constructs compete with chromosomal kinetochores, reducing excessive bipolar #microtubule pulling forces.
bit.ly/48g0oTa
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Now out from our lab in @currentbiology.bsky.social!
An mTOR-Stat3-Stathmin pathway controls #centrosome and #microtubule dynamics for #oocyte polarization
www.cell.com/current-biol...
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Master the role of microtubules in cell division and transport for your exams. #CellBiology #Microtubule #USMLE
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My PhD work is up on bioRxiv! Read all about the #actin and #microtubule #cytoskeleton of the Rhizarian #amoeba Filoreta ramosa here: www.biorxiv.org/content/10.1...
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Understanding #microtubule dynamics: The synergy of technology, theory, and experiment. New Perspective from Richard McIntosh @colorado.edu: rupress.org/jcb/article/...
#Cytoskeleton #Biophysics #Microtubules
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Perspective from Richard McIntosh describing the history of research on #microtubule polymerization in terms of the ideas, technologies, and observations that have emerged as countless researchers have studied the dynamics of these essential cytoskeletal polymers. rupress.org/jcb/article/...
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Perspective @jcb.org by Richard McIntosh describing the history of research on #microtubule polymerization in terms of the ideas, technologies, and observations that have emerged as countless researchers have studied the dynamics of these essential cytoskeletal polymers. rupress.org/jcb/article/...
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New paper out now @cp-cellreports.bsky.social! If you would like to know, what it takes to turn a classical transport #kinesin motor into a decent #microtubule polymerase read on here www.cell.com/cell-reports.... (Pssst it's the N-terminal motor domain extension of budding yeast kinesin #Kip2)😉
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We have a fantastic #FREE Access #Review #article in #CYTOSKELETON for you!!! KIF14 as a Dual #Microtubule / F-#Actin Binding Protein Contributing to #Cytokinesis. Check it out here: onlinelibrary.wiley.com/doi/full/10....
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I’ll use this opportunity to highlight Tim Mitchison’s article in #MBoC
It’s not all about targeting cell division! #microtubule #MTA #cytoskeleton
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What a pleasure to collaborate with Laura #Schaedel and her team at @uni-saarland.de to study #microtubule damage and repair under mechanical load.
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