A mechanical ratchet drives unilateral cytokinesis - Nature Division of embryonic cells with an incomplete contractile ring occurs by a ratchet mechanism with repeated cycles of cytoplasmic stiffening, which stabilizes the contractile actin band, and fluidizat...

Animals with giant embryonic cells - that includes #sharks and #rays - do #cytokinesis differently; they repeatedly alter the stiffness of the #cytoplasm instead of using complete contractile rings of actin at the middle of the dividing cell

share.google/EUSBNrlTdYzs...

Textbooks challenged by new discovery about how cells divide Scientists have uncovered a surprising new way that giant embryonic cells divide—without relying on the classic “purse-string” ring long thought essential for splitting a cell in two. Studying zebrafi...

We're taught abt a full "drawstring" of actin causing the #cleavagefurrow of #cytokinesis in #mitosis. In animals w/ large amounts of yolk - #sharks, #birds, #reptiles - it's more complicated

Textbooks challenged by new discovery about how cells divide | ScienceDaily share.google/TtpwtUrQb9Nf...

Excited to share our latest work on how viruses “rewire” the cell division machinery of infected cells.

Investigating viral strategies provides insights into how key cellular processes are controlled, and where they can fail.

#CellBiology #Virology #Cytokinesis #APCC #GenomeStability #Adenovirus

Sensing danger at the bridge. Juan Martin-Serrano (@juanmartin-serrano.bsky.social) @kingscollegelondon.bsky.social discusses new work from Dam, Moreno, Brownlow, @longchrom.bsky.social and colleagues (rupress.org/jcb/article/...), in Spotlight: rupress.org/jcb/article/...
#Cytokinesis

Learn about Mitosis & Cell Division by making our paper model! See what happens at each stage of #mitosis & how #celldivision happens. Find out more here: buff.ly/xsmJclw

#EduSky #iteachbio #biologyteacher #scienceteacher #cells #chromosomes #nucleus #cytokinesis #interphase #metaphase #prophase

Bni5 regulates and coordinates #septin architecture and #myosin-II functions at the #CellDivision site, say Hiroki Okada, Erfei Bi and colleagues @upenn.edu: rupress.org/jcb/article/...

#Cytoskeleton #CellCycle #Biochemistry #Genetics #Cytokinesis

Spotlight: @juanmartin-serrano.bsky.social highlights work from Dam, Moreno, Brownlow, @longchrom.bsky.social et al. (rupress.org/jcb/article/...), which reveals how Srs2/PARI act as a missegregated chromatin sensor for NoCut, delaying cytokinetic abscission. rupress.org/jcb/article/...
#Cytokinesis

Roles of Srs2/PARI-family DNA helicases in NoCut checkpoint signaling and abscission regulation. New study from Monica Dam, David F. Moreno, Nicola Brownlow, Manuel Mendoza (@longchrom.bsky.social) and colleagues @igbmc.bsky.social: rupress.org/jcb/article/...

#Genetics #CellDivision #Cytokinesis

In @jcb.org, Okada, Bi et al. @upenn.edu show that Bni5 interacts with #septin filaments, septin-associated kinase, and #myosin-II to regulate septin hourglass architecture and remodeling, retrograde #actin flow, and #cytokinesis. rupress.org/jcb/article/...

#CellDivision #Cytoskeleton #Genetics

Okada, Bi et al. @upenn.edu show that Bni5 interacts with #septin filaments, septin-associated kinase, and #myosin-II to regulate septin hourglass architecture and remodeling, retrograde #actin flow, and #cytokinesis rupress.org/jcb/article/...

#Biochemistry #CellDivision #Cytoskeleton #Genetics

Dam, Moreno, Brownlow, @longchrom.bsky.social et al. @igbmc.bsky.social identify Srs2 as a key mediator of abscission inhibition in yeast and show that its human paralog PARI regulates abscission-associated events. rupress.org/jcb/article/...

#Cytokinesis

New in @jcb.org: Dam, Moreno, Brownlow, @longchrom.bsky.social et al. @igbmc.bsky.social identify Srs2 as a key mediator of abscission inhibition in yeast and show that its human paralog PARI regulates abscission-associated events. rupress.org/jcb/article/...

#Cytokinesis

Working model for the major pathways of plasma membrane deposition and septum formation during cytokinesis. The septum is illustrated asymmetrically intentionally. The top half septum shows septum formation and digestion of the primary septum; the bottom half shows septum formation. (1) F-BAR protein Cdc15 (and others) anchor the contractile ring to the plasma membrane, which recruits the β(1,3)-glucan synthase Bgs1 and its adaptor Sbg1 for primary septum formation. (2) Association of the F-BAR protein Rga7 and coiled-coil protein Rng10 with the Munc13/UNC-13 protein Ync13 recruits the TRAPP-II complex along the cleavage furrow, which tethers vesicles and primes the SM protein Sec1 and its binding partner Mso1 for the SNARE complex assembly to trigger vesicle fusion with the plasma membrane. This pathway maintains normal levels and distribution of gluacan synthases Bgs4/Smi1 and Ags1 for secondary septum formation. (3) The anillin Mid2 and septin rings restrict most of the exocyst complex to the rim of cleavage furrow to tether secretory vesicles loaded with the glucanases Eng1 and Agn1 and other cargos for digestion of primary septum to trigger daughter-cell separation.

How is #cytokinesis coordinated to ensure successful #CellDivision? Jian-Qiu Wu @sophiemartinlab.bsky.social &co show that the Ync13-Rga7-Rng10 module coordinates selective tethering & fusion of vesicles containing glucan synthases at the division site @plosbiology.org 🧪 plos.io/43zJ35Z

Working model for the major pathways of plasma membrane deposition and septum formation during cytokinesis. The septum is illustrated asymmetrically intentionally. The top half septum shows septum formation and digestion of the primary septum; the bottom half shows septum formation. (1) F-BAR protein Cdc15 (and others) anchor the contractile ring to the plasma membrane, which recruits the β(1,3)-glucan synthase Bgs1 and its adaptor Sbg1 for primary septum formation. (2) Association of the F-BAR protein Rga7 and coiled-coil protein Rng10 with the Munc13/UNC-13 protein Ync13 recruits the TRAPP-II complex along the cleavage furrow, which tethers vesicles and primes the SM protein Sec1 and its binding partner Mso1 for the SNARE complex assembly to trigger vesicle fusion with the plasma membrane. This pathway maintains normal levels and distribution of gluacan synthases Bgs4/Smi1 and Ags1 for secondary septum formation. (3) The anillin Mid2 and septin rings restrict most of the exocyst complex to the rim of cleavage furrow to tether secretory vesicles loaded with the glucanases Eng1 and Agn1 and other cargos for digestion of primary septum to trigger daughter-cell separation.

How is #cytokinesis coordinated to ensure successful #CellDivision? Jian-Qiu Wu @sophiemartinlab.bsky.social &co show that the Ync13-Rga7-Rng10 module coordinates selective tethering & fusion of vesicles containing glucan synthases at the division site @plosbiology.org 🧪 plos.io/43zJ35Z

Working model for the major pathways of plasma membrane deposition and septum formation during cytokinesis. The septum is illustrated asymmetrically intentionally. The top half septum shows septum formation and digestion of the primary septum; the bottom half shows septum formation. (1) F-BAR protein Cdc15 (and others) anchor the contractile ring to the plasma membrane, which recruits the β(1,3)-glucan synthase Bgs1 and its adaptor Sbg1 for primary septum formation. (2) Association of the F-BAR protein Rga7 and coiled-coil protein Rng10 with the Munc13/UNC-13 protein Ync13 recruits the TRAPP-II complex along the cleavage furrow, which tethers vesicles and primes the SM protein Sec1 and its binding partner Mso1 for the SNARE complex assembly to trigger vesicle fusion with the plasma membrane. This pathway maintains normal levels and distribution of gluacan synthases Bgs4/Smi1 and Ags1 for secondary septum formation. (3) The anillin Mid2 and septin rings restrict most of the exocyst complex to the rim of cleavage furrow to tether secretory vesicles loaded with the glucanases Eng1 and Agn1 and other cargos for digestion of primary septum to trigger daughter-cell separation.

How is #cytokinesis coordinated to ensure successful #CellDivision? Jian-Qiu Wu @sophiemartinlab.bsky.social &co show that the Ync13-Rga7-Rng10 module coordinates selective tethering & fusion of vesicles containing glucan synthases at the division site @plosbiology.org 🧪 plos.io/43zJ35Z

September in preprints – Cell biology edition - preLights

Thank you, fellow preLighter @sristi.bsky.social for mentioning our #Atlas 🗺️ on #Cytokinesis ⌛ in the September in #preprints list @prelights.bsky.social 😊

prelights.biologists.com/prelists/sep...

Helge Ewers pointing towards a huge screen that shows different stages of cytokinesis; Illustrated by individual and averaged U-ExM images of Septin2-GFP (green) and tubulin (magenta)

Our very own @ewerslab.bsky.social presents our story on Multiscale imaging of #Cytokinesis, harnessing #ExM 🔬🫧 of cytokinetic bridges 👀 🍬at this year's #BiomembraneDays25 👏🏽.
Read more? 👉🏽 doi.org/10.1101/2025...

Now out on bioRxiv. 🥳My research on #cytokinesis, averaging thousands of #ExM images🔬, creating a dynamic atlas of cytokinesis 🦠⏳. Here's an animated sneak peek of what we found. Better resolution on bioRxiv😄 #PSFoftheGIF

We have a fantastic #FREE Access #Review #article in #CYTOSKELETON for you!!! KIF14 as a Dual #Microtubule / F-#Actin Binding Protein Contributing to #Cytokinesis. Check it out here: onlinelibrary.wiley.com/doi/full/10....

I’m pleased to share the latest preprint from the Iyer Lab! 🎉
We uncover a novel role for dynamin in regulating spindle pole assembly and PLK-1 localization during late mitosis in C. elegans embryos.
Read it here 👉 www.biorxiv.org/cgi/content/...
#CellBiology #C_elegans #Cytokinesis
#Dynamin #PLK1

Our June issue is here! rupress.org/jcb/issue/22...
The cover shows end-on views of the cleavage planes during #cytokinesis in one-cell embryos of the nematode #Celegans. From Lebedev et al. @zaninlab.bsky.social‬: (doi.org/10.1083/jcb....).

@jcb.org's June issue is here! rupress.org/jcb/issue/22...
The cover shows end-on views of the cleavage planes during #cytokinesis in one-cell embryos of the nematode #Celegans. From Lebedev et al. @zaninlab.bsky.social‬: (doi.org/10.1083/jcb....).

Anillin mediates unilateral furrowing during cytokinesis by limiting RhoA binding to its effectors The authors show that anillin mediates unilateral cytokinesis by blocking the effector binding site of active RhoA. The interaction between active RhoA and

Anillin links up with RhoA to break the symmetry of cytokinetic ring closure.
Guillaume Chambaud, Vlad Martin, and Gilles Hickson @chusaintejustine.bsky.social discuss work from Lebedev et al. @zaninlab.bsky.social (doi.org/10.1083/jcb....) in Spotlight: rupress.org/jcb/article/...

#Cytokinesis

KIF2A stabilizes intercellular bridge #microtubules to maintain mouse embryonic stem cell #cytokinesis, say Lieke Stockmann, Sreya Basu, Niels Galjart and colleagues @erasmusmc.bsky.social: rupress.org/jcb/article/...

#CellCycle #CellDivision #Cytoskeleton #StemCells #Kinesins

Anillin mediates unilateral furrowing during cytokinesis by limiting RhoA binding to its effectors The authors show that anillin mediates unilateral cytokinesis by blocking the effector binding site of active RhoA. The interaction between active RhoA and

Spotlight: Chambaud et al discuss new work from Lebedev et al @zaninlab.bsky.social (doi.org/10.1083/jcb....) that reveals how anillin differentially regulates RhoA at the leading and lagging edges of the contractile ring during unilateral furrow ingression. rupress.org/jcb/article/...
#Cytokinesis

In @jcb.org, Stockmann, Basu, Galjart et al. show that, in mouse embryonic #stemcells, the #kinesin-13 member KIF2A converts from a microtubule depolymerase during metaphase to a microtubule stabilizer during #cytokinesis, thereby helping to maintain pluripotency rupress.org/jcb/article/...

Stockmann, Basu, Galjart et al @erasmusmc.bsky.social show that, in mouse embryonic #stemcells, the #kinesin-13 member KIF2A converts from a microtubule depolymerase during metaphase to a microtubule stabilizer during #cytokinesis, thereby helping to maintain pluripotency rupress.org/jcb/article/...

A cortical pool of LIN-5 (NuMA) controls cytokinetic furrow formation and #cytokinesis completion. New study from Kuheli Adhikary, Sukriti Kapoor, and Sachin Kotak (Indian Institute of Science Bangalore): rupress.org/jcb/article/...

#Development #CellDivision #Celegans

Adhikary et al. show that LIN-5/GPR-1/2 complexes present at the polar and lateral regions of the cell membrane facilitate the accumulation of contractile ring components at furrow formation and stabilize them in the midbody, thus aiding in various #cytokinesis processes. rupress.org/jcb/article/...

Adhikary et al. show that LIN-5/GPR-1/2 complexes present at the polar and lateral regions of the cell membrane facilitate the accumulation of contractile ring components at furrow formation and stabilize them in the midbody, thus aiding in various #cytokinesis processes. rupress.org/jcb/article/...