#Tubulin #prevents toxic #protein #clumps in the brain, fighting back against #neurodegeneration
A potential new way may fight against #Alzheimer's & #Parkinson's diseases, linked to the toxic accumulation of Tau & alpha synuclein protein clumps... scitechupdates.com/t...
#Tubulin Combats #Neurodegeneration by Blocking Toxic Protein Aggregates in the #Brain, #Alzheimers #Parkinsons #Tau #alphasynuclein @bcmhouston.bsky.social bioengineer.org/tubulin-comb...
Can #Tubulin, a protein essential for maintaining cellular structure, also protect against some forms of #neurodegeneration? A Ferron lab, L Lucas et al investigated this possibility. @natcomms.nature.com @bcmhouston.bsky.social blogs.bcm.edu/2026/03/10/f...
Study from the A. Ferreon lab, L. Lucas et al supports that #Tubulin can curb #Tau and #alphasynuclein toxic aggregation toward their healthy roles, a potential therapeutic strategy. @natcomms.nature.com @bcmhouston.bsky.social @neurosciencenews.bsky.social neurosciencenews.com/tubulin-tau-...
The A. Ferreon lab, L Lucas et al are changing our view of #tubulin, from a from passive casualty of #Alzheimer's and #Parkinson's diseases to potential active protector against toxic protein aggregation in these conditions. @bcmhouston.bsky.social @natcomms.nature.com www.bcm.edu/news/tubulin...
ATTENTION #tubulin fans! We have another #openaccess #Techniques and Procedures paper in #CYTOSKELETON! Expression, Purification, and #Microscopy-Based Assays for Engineered Recombinant Tyrosinated, Detyrosinated, and Δ2 #Human Tubulin. Read it here: onlinelibrary.wiley.com/doi/10.1002/...
Shu et al. found that downregulation of #microtubule proteins TUBB2A, TUBB3, and TUBB4B contributes to #neuronaldysfunction in #Alzheimer’s disease by impairing microtubule stability and promoting tau pathology. doi.org/10.4103/AGIN... #Tubulin #Neuroscience #Bioinformatics #ADresearch #Aging
ATTENTION #TUBULIN FANS!!! Have a look at this outstanding #openaccess Perspective in #CYTOSKELETON! C-Terminal Tail Elongation Adds a New Dimension to the Tubulin Code. onlinelibrary.wiley.com/doi/full/10....
Do you work with #tubulin? If so, have a look at this #openaccess TECHNIQUES paper in #CYTOSKELETON. Expression, Purification, and #Microscopy-Based Assays for Engineered Recombinant Tyrosinated, Detyrosinated, and Δ2 #Human Tubulin onlinelibrary.wiley.com/doi/full/10....
Novel PIKfyve/Tubulin Dual-target Inhibitor as a Promising Therapeutic Strategy for B-cell Acute Lymphoblastic Leukemia
This study highlights HZX-02-059, a dual-target inhibitor of #PIKfyve & #Tubulin, as lethal to #Bcell #AcuteLymphoblasticLeukaemia cells, underscoring its potential as a #therapeutic candidate for targeted #CancerTherapy. #medsky
Read: link.springer.com/article/10.1...
Tour de force #UExM study of #protist #cytoskeleton structures (>200 species🤯), led by @dudinlab.bsky.social, @gautamdey.bsky.social. A must for #tubulin & #centrin aficionados🤩
www.cell.com/cell/fulltex...
#Tubulin fans!!! Have you seen this #FREE access #review #article in #CYTOSKELETON? Post-Translational Modifications of Tubulin in Oocyte Maturation and Female Infertility. You can read it here: onlinelibrary.wiley.com/doi/full/10....
#Tubulin regulates stability and localization of STMN2 by binding preferentially to its soluble form, say Xiang Deng, Timothy Mitchison and colleagues @harvardmed.bsky.social: rupress.org/jcb/article/...
#ProteinHomeostasis #Neuroscience #Biochemistry #Cytoskeleton #Neurodegeneration #ALS
Another wonderful #FREE access #review #article is available in #CYTOSKELETON. TUBA4A: The Tale of an Unconventional #Tubulin. You'll find it here: onlinelibrary.wiley.com/doi/full/10....
#embo2025 #cytoskeleton meeting #iiserpune comes to a close. With a take on the history of #ptm modifications of #tubulin by Carsten Jahnke
We’re on the cover of @embojournal.org
Odin, from Norse mythology, emerges from the Odinarchaeota yellowstonii genome, holding FtsZ1 and FtsZ2 the ancestral twins of tubulin highlighting their evolutionary divergence in Asgard archaea. 👉 shorturl.at/n7iZE
#archaea #evolution #tubulin #cytoskeleton
Deng, Mitchison et al. @harvardmed.bsky.social employ two human cell models to elucidate how #tubulin binding, membrane association, and protein stability converge in the biology of STMN2, a protein implicated in amyotrophic lateral sclerosis. rupress.org/jcb/article/...
#Neuroscience #ALS
In @jcb.org, Deng, Mitchison et al. @harvardmed.bsky.social employ two human cell models to elucidate how #tubulin binding, membrane association, and protein stability converge in the biology of STMN2, a protein implicated in amyotrophic lateral sclerosis. rupress.org/jcb/article/...
#Neuroscience
The tubulin Techniques and Procedures papers keep coming in at #CYTOSKELETON. Have a look at this #openaccess paper: "Recombinant Monoclonal #Antibodies for Detecting the #Tubulin Post-Translational Modifications Glutamylation and Lysine-40 Acetylation". onlinelibrary.wiley.com/doi/full/10....
A fantastic #openaccess Techniques and Procedures paper from Kristen Verhey's lab is available in #CYTOSKELETON! Purification, Fluorescent Labeling, and Detyrosination of Mammalian #Cell #Tubulin for #Biochemical Assays. Check it out: onlinelibrary.wiley.com/doi/full/10.... @kjverhey1.bsky.social
Congratulation to @ac-almeida.bsky.social for the first work of her postdoc! If you like spheroids, tubulin -specially autoregulation- don't miss this one
#postdoclife #cytoskeleton #tubulin
Thrilled to see our work published in @embojournal.org
#asgard #archaea #cytoskeleton #tubulin #FtsZ
We sincerely appreciate the constructive peer review and the reviewers’ thoughtful, supportive feedback, which greatly strengthened our work.
Insights into the origins of the #tubulin / #FtsZ superfamily: @syncellbiolab.bsky.social, Pananghat Gayathri et al show that two #Asgard archaeal paralogs OdinFtsZ1 and OdinFtsZ2 form distinct filamental structures, and employ different modes of membrane tethering
www.embopress.org/doi/full/10....
New from Verhey lab @kjverhey1.bsky.social: "a renewable source of antibodies with high specificity and affinity towards tubulin glutamylation and acetylation"
recombinant rMAb-GT335 and rMAb-611B1
#microtubule #cilia #tubulin
onlinelibrary.wiley.com/doi/10.1002/...
Just for info, chemical fixation and labeling pre-expansion works good in my hands. 4x expansion with a 0.95NA x25 water objective.
#ProExM #celldivision #tubulin
#fluorescencefriday with #paxillin (🟥STAR RED) and #tubulin (🟦STAR ORANGE) in fixed U2OS cells. Imaged with #STED and deconvolved with #TRUESHARP image boosting.
Sample by Neha Koundinya, Brandeis University, Waltham, MA.
#STEDmicroscopy #superresolution
DNA-PAINT image of tubulin in green and mitochondria in magenta.
To celebrate #DNADay from last week, this #FluorescenceFriday we have a #DNAPAINT image of #Tubulin ( #cytoskeleton ) in green and the #mitochondria protein #Tomm20 in magenta, taken by ONI former scientist Dr Nina Jajčanin Jozić using the #Nanoimager with probes from @massivephotonics.bsky.social.
Online today: Selective #tubulin -binding drugs induce #pericyte phenotype switching and anti- #cancer immunity 👉 doi.org/10.1038/s443...
By Bo He, Ruth Ganss & colleagues @perkinsinstitute.bsky.social
Read also related N&V by April Risinger @uthealthsa.bsky.social 👉 doi.org/10.1038/s443...
Asgard archaea hold the key to the origin of microtubules in eukaryotes. A milestone study highlights the fact that having a microbial culture is crucial for groundbreaking discoveries.
@CellCellPress
#tubulin #evolution #archaea #cytoskeleton
www.cell.com/cell/fulltex...
Lysosomal #LAMP1 in red, #cytoskeleton #tubulin in cyan, nuclear #DNA staining in blue and the #PlasmaMembrane in gray.
While each cellular #organelle has specialized roles in the cell, their activities are well coordinated and are under a tight cross-regulation.
