Rsp5/NEDD4 and #ESCRT regulate TDP-43 toxicity and turnover via an endolysosomal clearance mechanism. New study from Aaron Byrd, Lucas J. Marmorale, Ross Buchan and colleagues @uarizona.bsky.social: rupress.org/jcb/article/...
#ProteinHomeostasis #Genetics #Trafficking #Neuroscience #ALS
Cell-type-specific spatiotemporal control of GFP-tagged protein degradation in mice. New study from Alexandra Prado-Mantilla, Terry Lechler @terrylechler.bsky.social and colleagues @duke-university.bsky.social: rupress.org/jcb/article/...
#Technology #ProteinHomeostasis
#Pexophagy meets #physiology. In this Spotlight, Michael Clague @liverpooluni.bsky.social discusses recent work by Xiong et al. (rupress.org/jcb/article/...), describing a mouse model to monitor pexophagy dynamics in vivo. rupress.org/jcb/article/...
#ProteinHomeostasis #Peroxisomes #Autophagy
In @jcb.org, Prado-Mantilla, @terrylechler.bsky.social et al. develop a mouse line to allow cell type–specific, rapid, and reversible degradation of GFP-tagged proteins. rupress.org/jcb/article/...
#Technology #ProteinHomeostasis
Prado-Mantilla, @terrylechler.bsky.social et al. develop a mouse line to allow cell type–specific, rapid, and reversible degradation of GFP-tagged proteins. rupress.org/jcb/article/...
#Technology #ProteinHomeostasis
Spotlight: Michael J. Clague @liverpooluni.bsky.social highlights recent work by Xiong et al. (rupress.org/jcb/article/...), describing a mouse model to monitor #pexophagy dynamics in vivo. rupress.org/jcb/article/...
#Physiology #ProteinHomeostasis #Peroxisomes #Autophagy
Spotlight: Michael J. Clague @liverpooluni.bsky.social highlights recent @jcb.org study by Xiong et al. (rupress.org/jcb/article/...), describing a mouse model to monitor #pexophagy dynamics in vivo. rupress.org/jcb/article/...
#Physiology #ProteinHomeostasis #Peroxisomes #Autophagy
#Tubulin regulates stability and localization of STMN2 by binding preferentially to its soluble form, say Xiang Deng, Timothy Mitchison and colleagues @harvardmed.bsky.social: rupress.org/jcb/article/...
#ProteinHomeostasis #Neuroscience #Biochemistry #Cytoskeleton #Neurodegeneration #ALS
Dominant-negative isoform of TDP-43 is regulated by #ALS-linked #RNA-binding proteins, say Minami Hasegawa-Ogawa, Hirotaka James Okano and colleagues (Jikei University School of Medicine): rupress.org/jcb/article/...
#Disease #Neuroscience #ProteinHomeostasis #RNAbiology
Hasegawa-Ogawa, Okano et al. identify a dominant-negative TDP-43 isoform regulated by #ALS-linked #RNA-binding proteins. hnRNP K promotes its expression, while hnRNP A1 and FUS suppress it. rupress.org/jcb/article/...
#Disease #Neuroscience #ProteinHomeostasis #RNAbiology
In @jcb.org, Hasegawa-Ogawa, Okano et al. identify a dominant-negative TDP-43 isoform regulated by #ALS-linked #RNA-binding proteins. hnRNP K promotes its expression, while hnRNP A1 and FUS suppress it. rupress.org/jcb/article/...
#Disease #Neuroscience #ProteinHomeostasis #RNAbiology
Exciting new study by the @trentini-lab.bsky.social #ProteinHomeostasis #RQC #CFTR
#Ubiquitin chain variability directs substrates of the Tul1 ubiquitin ligase complex to different degradation pathways, say Devon Dennison and Ryan Baldridge @umich.edu: rupress.org/jcb/article/...
#Biochemistry #ProteinHomeostasis #Golgi
In @jcb.org, Dennison and Baldridge @umich.edu reveal how the #Golgi-localized Tul1 #ubiquitin ligase complex targets substrates to the #proteasome versus the vacuole in S. cerevisiae. rupress.org/jcb/article/...
#Biochemistry #ProteinHomeostasis
Dennison and Baldridge @umich.edu reveal how the #Golgi-localized Tul1 #ubiquitin ligase complex targets substrates to the #proteasome versus the vacuole in S. cerevisiae. rupress.org/jcb/article/...
#Biochemistry #ProteinHomeostasis
3/
Perhaps most intriguingly:
🌡️ Temperature
☀️ Light
🌿 Brassinosteroids
🌱 ABA
→ All influence PILS abundance via ERAD!
This positions PILSes as selective, context-dependent ERAD substrates.
A new layer of growth regulation!
#Auxin #PlantDevelopment #ProteinHomeostasis
#Ubiquitin-SUMO tag-team wrestles acute promyelocytic #leukemia. Spotlight from Alfred C.O. Vertegaal highlights new work from Jaffray and colleagues of the Hay group (doi.org/10.1083/jcb....): rupress.org/jcb/article/...
#Biochemistry #ProteinHomeostasis
A multifunction murine Col4a1 allele reveals potential gene therapy parameters for Gould syndrome. New study from Mao Mao, Douglas Gould (UCSF) and colleagues: rupress.org/jcb/article/...
#Adhesion #Disease #ProteinHomeostasis #Genetics
PML mutants from arsenic-resistant patients reveal SUMO1-TOPORS and SUMO2-RNF4 degradation pathways. New study from Ellis Jaffray, Ronald Hay and colleagues @dundee.ac.uk: rupress.org/jcb/article/...
#Cancer #ProteinHomeostasis #Biochemistry #CellSignaling #Leukemia
Rhythmic TDP-43 affects RNA splicing of USP13, resulting in alteration of BMAL1 ubiquitination, say Jianlan Gu, Mingming Yang, Liti Zhang, Chen Hu, Fei Liu, Hengxiang Cui and colleagues. rupress.org/jcb/article/...
#ProteinHomeostasis #Neuroscience #Neurodegeneration #CircadianRhythm
ESCRT-I and PTPN23 mediate #microautophagy of ubiquitylated tau aggregates, say Yusen Men, Shoshiro Hirayama, Shigeo Murata @utokyoofficial.bsky.social and colleagues: rupress.org/jcb/article/...
#Autophagy #ProteinHomeostasis #Biochemistry #Neuroscience
Men, Hirayama, Murata et al. @utokyoofficial.bsky.social show that misfolded protein aggregates are degraded through #microautophagy, a process mediated by the UBAP1-containing ESCRT-I complex and PTPN23. rupress.org/jcb/article/...
#autophagy #neuroscience #proteinhomeostasis
Structural insights into the coupling between VCP, an essential unfoldase, and a deubiquitinase. New study from Lauren Vostal, Tarun Kapoor and colleagues @rockefelleruniv.bsky.social: rupress.org/jcb/article/...
#StructuralBiology #Biochemistry #ProteinHomeostasis #CryoEM
Cytoplasmic #ribosomes on #mitochondria alter the local membrane environment for protein import, say Ya-Ting Chang, Danielle Grotjahn (@nanigrotjahn.bsky.social) @scripps.edu and colleagues: rupress.org/jcb/article/...
#ProteinHomeostasis #Organelles #StructuralBiology #CryoET
Ketone body β-hydroxybutyrate restores protein balance and targets Alzheimer’s-linked aggregates 🧠🔬✨ www.news-medical.net/news/2024120... #Ketone #Neurodegeneration #Alzheimers #Aging #Brain #ProteinHomeostasis #KetoneTherapy #Proteostasis @cellchembiol.bsky.social
