Articles in our latest collection focus on the roles of ATG9 and LC3 interacting regions, plus mechanisms of selective #autophagy involving Rab #GTPases, #mitophagy, and #pexophagy. 👉 rupress.org/jcb/collecti...
#GRC
The p97 ATPase and its adaptor UBXD8 maintain #peroxisome pools by preventing #pexophagy. From Iris Montes, Malavika Raman @maliramanlab.bsky.social and colleagues: rupress.org/jcb/article/...
📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#GRC
PEX14 acts as a molecular link between optineurin and the autophagic machinery to induce #pexophagy. From Hongli Li, Marc Fransen and colleagues (KU Leuven): rupress.org/jcb/article/...
📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#GRC
To accompany the #Autophagy #GRC, explore our recent autophagy special collection, incl. the role of ATG 9 in autophagosome formation & the regulation of lysosomal function, and the regulation of selective autophagy, incl. #mitophagy and #pexophagy 👉 rupress.org/jcb/collecti...
Articles in our latest collection focus on the roles of ATG9 and LC3 interacting regions, plus mechanisms of selective #autophagy involving Rab GTPases, #mitophagy, and #pexophagy. 👉 rupress.org/jcb/collecti...
The p97 ATPase and its adaptor UBXD8 maintain #peroxisome pools by preventing #pexophagy. From Iris Montes, Malavika Raman @maliramanlab.bsky.social and colleagues: rupress.org/jcb/article/...
📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#KSAutophagy26
PEX14 acts as a molecular link between optineurin and the autophagic machinery to induce #pexophagy. From Hongli Li, Marc Fransen and colleagues (KU Leuven): rupress.org/jcb/article/...
📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#KSAutophagy26
Explore recent advances in #autophagy research, incl. the role of ATG 9 in autophagosome formation & the regulation of lysosomal function, and the regulation of selective autophagy, incl. #mitophagy and #pexophagy 👉 rupress.org/jcb/collecti...
@keystonesymposia.bsky.social
#KSAutophagy26
#Pexophagy meets #physiology. In this Spotlight, Michael Clague @liverpooluni.bsky.social discusses recent work by Xiong et al. (rupress.org/jcb/article/...), describing a mouse model to monitor pexophagy dynamics in vivo. rupress.org/jcb/article/...
#ProteinHomeostasis #Peroxisomes #Autophagy
In vivo mapping of #peroxisome dynamics and #pexophagy using PO-TRG and CA-PO-TRG reporter mice. New study from Yue Xiong, Weihua Gao, Zelai Wu, Xiukui Gao, Qiming Sun (Zhejiang University) and colleagues: rupress.org/jcb/article/...
#Organelles #Technology
Spotlight: Michael J. Clague @liverpooluni.bsky.social highlights recent work by Xiong et al. (rupress.org/jcb/article/...), describing a mouse model to monitor #pexophagy dynamics in vivo. rupress.org/jcb/article/...
#Physiology #ProteinHomeostasis #Peroxisomes #Autophagy
Spotlight: Michael J. Clague @liverpooluni.bsky.social highlights recent @jcb.org study by Xiong et al. (rupress.org/jcb/article/...), describing a mouse model to monitor #pexophagy dynamics in vivo. rupress.org/jcb/article/...
#Physiology #ProteinHomeostasis #Peroxisomes #Autophagy
PEX14 acts as a molecular link between optineurin and the autophagic machinery to induce #pexophagy, say Hongli Li, Marc Fransen and colleagues (KU Leuven): rupress.org/jcb/article/...
#Biochemistry #Organelles #Autophagy #Peroxisomes
Hongli Li, Marc Fransen et al. identify PEX14 as a key link between optineurin and the autophagic machinery in #pexophagy, the selective degradation of #peroxisomes. This discovery advances our understanding of #peroxisome clearance and disease. rupress.org/jcb/article/...
#Autophagy #Organelles
In @jcb.org, Hongli Li, Marc Fransen et al. identify PEX14 as a key link between optineurin and the autophagic machinery in #pexophagy, the selective degradation of #peroxisomes. This discovery advances our understanding of #peroxisome clearance and disease. rupress.org/jcb/article/...
#Autophagy
The p97 ATPase and its adaptor UBXD8 maintain #peroxisome pools by preventing #pexophagy, say Iris Montes, Malavika Raman @maliramanlab.bsky.social @tufts.edu and colleagues: rupress.org/jcb/article/...
@joshilaboratory.bsky.social
#Biochemistry #Organelles
In @jcb.org, Montes et al. @maliramanlab.bsky.social @tufts.edu find the p97 ATPase and its adaptor UBXD8 maintain #peroxisome abundance by suppressing #pexophagy. p97-UBXD8 degrade ubiquitylated peroxisomal proteins to bypass recognition by #autophagy receptors. rupress.org/jcb/article/...
Montes et al. @maliramanlab.bsky.social @tufts.edu find the p97 ATPase and its adaptor UBXD8 maintain #peroxisome abundance by suppressing #pexophagy. p97-UBXD8 degrade ubiquitylated peroxisomal proteins to bypass recognition by #autophagy receptors. rupress.org/jcb/article/...
#Biochemistry
As my #NewPI journey is starting I re-share my latest publication: 👉We uncovered a #phosphate #metabolite sensor, binding and regulating the #autophagy Atg1/ULK1 initiation complex to regulate #pexophagy in response to
phosphate availability. nature.com/articles/s41556-024-01348-4
Visualize global & tissue-specific #Pexophagy in #Drosophila 🤠
Pexo-QC
Pexo-Keima
SKL signal for translocation to #Peroxisome matrix
@drbaronefg.bsky.social l #OpenBiology 2025
royalsocietypublishing.org/doi/10.1098/...
Read the excellent🧵from 1st auth Dr. Barone 👇
bsky.app/profile/drba...
🧠 Why does this matter?
Peroxisomes regulate lipid metabolism & ROS detox, and their dysfunction is linked to neurodegeneration & Zellweger spectrum disorders.
Understanding in vivo pexophagy mechanisms provides new insights into organelle homeostasis & disease.
#Autophagy #Pexophagy #Drosophila
DurreShahwar Muhammad, a new PI at Umass Amherst is talking on the importance of #pexophagy www.umass.edu/biochemistry... #plantproteolysis2025
