💡Available online - the Spotlight "Cytosolic AcCoA: a metabolic signal bridging nutrient sensing and mitophagy" from Jiayi Chen and Xin Pan.
#CytosolicAcCoA #Mitophagy #Mitochondria #MetabolicStress
Read it here: authors.elsevier.com/a/1mrIK3S6Gf...
The innovative bio-sensor from BRIC-RGCB that tracks cancer’s survival secrets
For a deep dive, check out:
researchmatters.in/news/cancer-...
#cancer #cancertherapy #innovation #mitophagy #scicomm #science #sciencecommunication #IndianScience #ScienceinIndia
This week, we discuss a study from the lab of Dr. Trista North (@tristanorth.bsky.social!
It shows that #HSPCs expand while staying multipotent thanks to tightly controlled ROS levels regulated by developmental #mitophagy.
📄 https://go.nature.com/4tWuJ3e
🎧 https://bit.ly/46XtIy5
Articles in our latest collection focus on the roles of ATG9 and LC3 interacting regions, plus mechanisms of selective #autophagy involving Rab #GTPases, #mitophagy, and #pexophagy. 👉 rupress.org/jcb/collecti...
#GRC
The #mitophagy receptors BNIP3 and NIX mediate tight attachment and expansion of the isolation membrane to #mitochondria. From Shun-ichi Yamashita, Ritsuko Arai, Tomotake Kanki, Satoshi Waguri et al. rupress.org/jcb/article/...
📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#GRC
Trachsel-Moncho, @annesimonsen.bsky.social et al. identify the endosomal protein SNX10 as a modulator of piecemeal #mitophagy of OXPHOS machinery components and mitochondrial homeostasis. rupress.org/jcb/article/...
📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#GRC
To accompany the #Autophagy #GRC, explore our recent autophagy special collection, incl. the role of ATG 9 in autophagosome formation & the regulation of lysosomal function, and the regulation of selective autophagy, incl. #mitophagy and #pexophagy 👉 rupress.org/jcb/collecti...
Slm35's role in mitophagy depends on the RTG pathway. Cultures of the indicated strains were treated with 8 mM H2O2 for 3 h (+) or left untreated (−), then serially diluted and spotted onto YPD plates. Plates were incubated at 30°C for 48 h.
Hilario Ruelas-Ramírez & co describe how the mitochondrial protein Slm35 works as a negative regulator of #mitophagy, acting through retrograde signaling to the nucleus, and highlights its role in fine-tuning mitochondrial quality control. doi.org/10.1242/bio....
❓ Solving mitochondria isolation challenges: Traditional enzymatic methods compromise mitochondrial surface proteins in #Yeast; new glass bead mechanical approach preserves Atg32 integrity for quantitative #Mitophagy analysis
🔬 #YeastResearch #SGD
www.yeastgenome.org/reference/S1...
#Highlight in #MedComm_Oncology
The #Acetyl-CoA-#NLRX1 Axis Acts as a Key Player in #Mitophagy and Drug #Resistance doi.org/10.1002/mog2...
The highlighted article in @nature.com ：https://doi.org/10.1038/s41586-025-09745-x
Lindqvist-type Polyoxometalates Act as Anti-breast Cancer Drugs via Mitophagy-induced Apoptosis
A novel Lindqvist-type polyoxometalate MO-4 shows strong anti-breast cancer activity by raising #MitochondrialROS to trigger #mitophagy and #apoptosis, reducing #tumor growth and #metastasis in vivo, highlighting promise as a therapeutic candidate.
Read: doi.org/10.1007/s115...
#Melatonin improves spermatogenesis and alleviates oxidative stress in cryopreserved testicular tissue through suppression of the ROS/PINK1-Parkin #mitophagy axis.
www.sciencedirect.com/science/arti...
STING drives pressure overload–induced #CardiacFibrosis and remodeling by promoting #inflammation, oxidative stress, and fibroblast activation, while #mitophagy limits cytosolic #mtDNA and STING signaling. #HeartFailure
#OpenAccess: doi.org/10.1016/j.ge...
👋Our February issue is out!
Cover: spatial #transcriptomics
👉Review: telomeric #chromatin
🔬 #mitochondria #mitophagy #senescence #p53 #epigenetics #glioblastoma #IDR #immunotherapy #cGASSTING #apoptosis #lysosomes & more!
www.nature.com/ncb/volumes/...
☕Thendral et al. describe a mitophagic programme that removes deleterious mtDNA during the oocyte-to-zygote transition in C. elegans, promoting #mitochondria health and offspring survival. Loss of this #mitophagy leads to mutant mtDNA accumulation.
👉https://rdcu.be/e3tpJ
bit.ly/4aqi7Zk
Articles in our latest collection focus on the roles of ATG9 and LC3 interacting regions, plus mechanisms of selective #autophagy involving Rab GTPases, #mitophagy, and #pexophagy. 👉 rupress.org/jcb/collecti...
The #mitophagy receptors BNIP3 and NIX mediate tight attachment and expansion of the isolation membrane to #mitochondria. From Shun-ichi Yamashita, Ritsuko Arai, Tomotake Kanki, Satoshi Waguri et al. rupress.org/jcb/article/...
📕 In #Autophagy 2026 👉 rupress.org/jcb/collecti...
#KSAutophagy26
Trachsel-Moncho, @annesimonsen.bsky.social et al. identify the endosomal protein SNX10 as a modulator of piecemeal #mitophagy of OXPHOS machinery components and mitochondrial homeostasis. rupress.org/jcb/article/...
📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#KSAutophagy26
In a study published in Horticulture Research, scientists report the discovery of a key mitophagy regulator in Colletotrichum camelliae, the fungus responsible for anthracnose in tea oil trees.
#mitophagy #CaAtg8
Details: doi.org/10.1093/hr/uhaf121
Explore recent advances in #autophagy research, incl. the role of ATG 9 in autophagosome formation & the regulation of lysosomal function, and the regulation of selective autophagy, incl. #mitophagy and #pexophagy 👉 rupress.org/jcb/collecti...
@keystonesymposia.bsky.social
#KSAutophagy26
This study demonstrates that the activation of NMN-SIRT1 signaling is crucial for reducing adverse pregnancy outcomes by ameliorating placental dysfunction induced by perinatal oxidative stress.
doi.org/10.59717/j.x...
#lifesciences #oxidativestress #mitophagy
Left panel: Immunofluorescent microscopy showing that Mtch mutant intestine cells (blue nuclei that lack red dye) fail to clear mitochondria marker protein ATP5A (green). Right panel: Transmission electron microscopy image of a mitochondrion engulfed by an autophagosome of a Drosophila intestine enterocyte.
Mitophagy is critical for cellular health & associated with multiple diseases. @baehreckelab.bsky.social &co show that the OMM protein Mtch regulates #mitophagy during #Drosophila intestinal development, by modulating the insertion of mitophagy receptor BNIP3 @plosbiology.org 🧪 plos.io/45uyBhg
Left panel: Immunofluorescent microscopy showing that Mtch mutant intestine cells (blue nuclei that lack red dye) fail to clear mitochondria marker protein ATP5A (green). Right panel: Transmission electron microscopy image of a mitochondrion engulfed by an autophagosome of a Drosophila intestine enterocyte.
Mitophagy is critical for cellular health & associated with multiple diseases. @baehreckelab.bsky.social &co show that the OMM protein Mtch regulates #mitophagy during #Drosophila intestinal development, by modulating the insertion of mitophagy receptor BNIP3 @plosbiology.org 🧪 plos.io/45uyBhg
Left panel: Immunofluorescent microscopy showing that Mtch mutant intestine cells (blue nuclei that lack red dye) fail to clear mitochondria marker protein ATP5A (green). Right panel: Transmission electron microscopy image of a mitochondrion engulfed by an autophagosome of a Drosophila intestine enterocyte.
Mitophagy is critical for cellular health & associated with multiple diseases. @baehreckelab.bsky.social &co show that the OMM protein Mtch regulates #mitophagy during #Drosophila intestinal development, by modulating the insertion of mitophagy receptor BNIP3 @plosbiology.org 🧪 plos.io/45uyBhg
Good morning everyone, below is last issue of #mitophagy news 🪫 🔋 🗑️
biomed.news/bims-tofagi/...
This week you'll find insights on the role of mitophagy in germline cells and in inheritance of mtDNA, in mice and in the male arabidopsis germline
Thanks to @biomednews.bsky.social for pre-sorting
This review shows how disrupted #MitochondrialQualityControl—covering #biogenesis, dynamics, #Mitophagy, #Proteostasis, and stress responses—fuels oxidative injury, #inflammation, and lipid buildup in #Atherosclerosis, while MQC‑targeted therapies hold promise.
#OpenAccess: tinyurl.com/23jddr2m
Metabolic interventions are proving powerful tools to modulate aging at the mitochondrial level.
📍 Global Longevity Federation (GLF 2026)
🗓 Mar 23–24, 2026
🌍 Rome, Italy (Hybrid)
🔗 longevityfederation.com
#LongevityScience #AgingResearch #Inflammaging #Mitophagy #CardiacAging #HealthyLongevity
Drosophila models have been highly useful in dissecting the physiological roles of PINK1 and Parkin in #mitophagy
Led by 3 talented PhD students, we wrote a review summarising recent exciting discoveries and discussed these in context of current in vitro studies
portlandpress.com/biochemj/art...
Low Selenium and Low Protein Exacerbate Myocardial Damage in Keshan Disease by Affecting the PINK1/Parkin-mediated Mitochondrial Autophagy Pathway
#Selenium and protein deficiency worsen #MyocardialInjury in #KeshanDisease by disrupting mitochondrial function and activating the #PINK1Parkin-mediated #mitophagy pathway, marked by elevated #CardiacInjury markers and altered #autophagy signaling.
#OpenAccess: doi.org/10.1007/s115...
FIP200 regulates plasma B cell differentiation via mitochondrial and heme homeostasis. New study from Liling Xu, Facundo D. Batista and colleagues @ragoninstitute.bsky.social: rupress.org/jem/article/...
#LymphocyteBiology #Metabolism #Autophagy #Mitophagy
