Scientists discover why cancer drugs don’t work for everyone Scientists have uncovered a hidden reason why cancer treatments don’t work equally well for everyone. Certain drugs can become trapped inside lysosomes within tumor cells, forming slow-release…

"Scientists have uncovered a hidden reason why #cancer #treatments don't work equally well for every1. Certain drugs can become trapped inside #lysosomes within #tumor #cells, forming slow-release reservoirs that create uneven drug distribution.": buff.ly/VYnYLjj

via sciencedaily
#CancerResearch

Glad to share our new @cp-trendscellbio.bsky.social article! We discuss how repair condensates and lipid domains work together to restore lysosome integrity or deciding if it's time for lysophagy. #Lysosomes #Condensates #DamageSignature #Lipids #Ions Check it out: doi.org/10.1016/j.tc...

Mechanoresilience of #lysosomes conferred by TMEM63A. New study from Angelina S. Kim, Jing Ze Wu, Ruiqi Cai, and Spencer A. Freeman @sickkidsto.bsky.social: rupress.org/jcb/article/...

#Membrane #lipid #Organelles #Immunology #Metabolism

SOD1 is delivered to #lysosomes via #autophagy to maintain lysosomal function and integrity. From Yanzhe Zheng, Ruilin Tian, Yan Zhao and colleagues: rupress.org/jcb/article/...

📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#GRC

#Inserm #LaSciencePourLaSanté #Recherche #Santé #CellulesSouches #Lysosomes

Kim, Freeman et al. @sickkidsto.bsky.social describe a mechanism for #lysosomes to sense and respond to acute increases in their #membrane tension by relieving hydrostatic pressure via the outward transport of major osmoticants. rupress.org/jcb/article/...

#Lipid #Organelles #Immunology #Metabolism

In @jcb.org, Kim, Freeman et al. @sickkidsto.bsky.social describe a mechanism for #lysosomes to sense and respond to acute increases in their #membrane tension by relieving hydrostatic pressure via the outward transport of major osmoticants. rupress.org/jcb/article/...

#Lipid #Immunology

Some fab work from the amazing @jnsimon.bsky.social on the response of #mitochondria and #lysosomes to energetic stress
#metabolism
🧪

www.biorxiv.org/content/10.6...

👋Our February issue is out!
Cover: spatial #transcriptomics

👉Review: telomeric #chromatin
🔬 #mitochondria #mitophagy #senescence #p53 #epigenetics #glioblastoma #IDR #immunotherapy #cGASSTING #apoptosis #lysosomes & more!

www.nature.com/ncb/volumes/...

Autophagosome-lysosome mediated secretion of the thrombopoietin receptor is modulated by distinct driver mutations of myeloproliferative neoplasm - Leukemia Leukemia - Autophagosome-lysosome mediated secretion of the thrombopoietin receptor is modulated by distinct driver mutations of myeloproliferative neoplasm

Check out our article on lysosome-autophagosome mediated secretion of thrombopoietin receptor in MPN #Membranetrafficking #MPN #lysosomes
www.nature.com/articles/s41...

Live transporter recordings at #BPS2026

Real-time SSME on the SURFE²R N1, measured live on site.
Limited spots available, register to attend the live demos.
https://ow.ly/1svz50Y9g3R

#BPS2026 #Transporters #TMEM175 #SSME #Lysosomes #Electrophysiology #Collaboration

SOD1 is delivered to #lysosomes via #autophagy to maintain lysosomal function and integrity. From Yanzhe Zheng, Ruilin Tian, Yan Zhao and colleagues: rupress.org/jcb/article/...

📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#KSAutophagy26

Ca2+ and DRP1 drive endocytic lysosome reformation at tripartite contact sites Lysosomes are essential in maintaining cellular health. Endocytic lysosome reformation (ELR) regenerates functional lysosomes following degradation of endocytic cargo, yet the mechanisms driving this process remain largely unknown. Here, we define the molecular machinery underlying ELR. We find that unlike autophagic lysosome reformation (ALR), ELR proceeds independently of mTOR and dynamin 2, but requires the mitochondrial fission GTPase DRP1. DRP1 mediates scission of endolysosomal tubules at contact sites with the endoplasmic reticulum (ER) and mitochondria. Disruption of DRP1 function or ER endolysosome contact results in elongated tubules, indicating defective lysosome reformation. Moreover, mitochondrial activity is essential for tubule initiation, and Ca2+ transfer from endolysosomes to mitochondria is crucial for ELR onset. Our findings reveal a dual role for mitochondria in ELR: first in ELR initiation and second in DRP1-dependent tubule fission at ER-mitochondria-endolysosome tripartite contact sites, uncovering the previously unappreciated role of mitochondria in endolysosome remodeling and fission. ### Competing Interest Statement The authors have declared no competing interest. Swiss National Science Foundation, 320030-231859, 310030-197779 University of Basel, https://ror.org/02s6k3f65

Check out our newest findings on how #lysosomes are generated from #endolysosomes. Great work from @samit2104.bsky.social ! @biozentrum.unibas.ch , @unibas.ch #cellbio #cell #organelles
Ca2+ and DRP1 drive endocytic lysosome reformation at tripartite contact sites www.biorxiv.org/content/10.6...

Secretome translation shaped by lysosomes and lunapark-marked ER junctions - Nature Live-cell imaging of mRNA encoding secretome proteins and translated nascent peptide markers show that secretome translation occurs at endoplasmic reticulum junctions near lysosomes, requires lun...

This week #JournalClub @labsoap.bsky.social #lysosomes #ER #secretion @nature.com www.nature.com/articles/s41...

Plasma membrane-to-lysosome FGR signaling regulates #endocytosis-associated #lysosome homeostasis, say Qiuyuan Yin, Chonglin Yang and colleagues (Yunnan University): rupress.org/jcb/article/...

#Organelles #Lysosomes

📰Check out our series of Issues thematically aligned with the expertise of our academic editors

Explore the 'In the Limelight' series
🔦https://buff.ly/4b4aRkm

#AlzheimersDisease #RNAbiology #Glycosphingolipids #Neurotransmitter #Antivirals #Lysosomes #Condensates #Bioplastics

Join us today for an exciting @crc1430.bsky.social seminar at @unidue.bsky.social! We’re happy to welcome Christian Ungermann, who will be presenting “Insights into endolysosomal membrane homeostasis.” 🔬✨

#Endosomes #Lysosomes #MembraneTrafficking #CellBiology #MembraneFusion

Aging is associated with lysosomal enlargement. Top left: Representative images of three different lysosomal morphologies in the hypodermis during aging. Top right: Ratio of animals exhibiting different lysosomal morphologies in the hypodermis during aging. Chi-square and Fisher’s exact test. n = 34–35 animals. Bottom: Working model of the regulation and function of lysosomal enlargement. Lysosomal enlargement occurs as a response to functional decline during aging. Upon lysosomal dysfunction, the transcription factor SKN-1 is activated to promote lysosomal enlargement by limiting fission in a BORC-dependent manner. This enlargement enhances lysosomal degradation capacity, serving as a beneficial adaptive response. In long-lived glp-1 mutants, SKN-1 activation similarly drives lysosomal enlargement, boosting degradation capacity and contributing to their extended life span.

Lysosomes are important for cellular degradation & signal transduction, but decline & change shape with age. This study shows that dysfunctional #aging #lysosomes undergo enlargement (promoted by the TF SKN-1) as a compensatory mechanism to sustain function @plosbiology.org 🧪 plos.io/4pjDX6V

Aging is associated with lysosomal enlargement. Top left: Representative images of three different lysosomal morphologies in the hypodermis during aging. Top right: Ratio of animals exhibiting different lysosomal morphologies in the hypodermis during aging. Chi-square and Fisher’s exact test. n = 34–35 animals. Bottom: Working model of the regulation and function of lysosomal enlargement. Lysosomal enlargement occurs as a response to functional decline during aging. Upon lysosomal dysfunction, the transcription factor SKN-1 is activated to promote lysosomal enlargement by limiting fission in a BORC-dependent manner. This enlargement enhances lysosomal degradation capacity, serving as a beneficial adaptive response. In long-lived glp-1 mutants, SKN-1 activation similarly drives lysosomal enlargement, boosting degradation capacity and contributing to their extended life span.

Lysosomes are important for cellular degradation & signal transduction, but decline & change shape with age. This study shows that dysfunctional #aging #lysosomes undergo enlargement (promoted by the TF SKN-1) as a compensatory mechanism to sustain function @plosbiology.org 🧪 plos.io/4pjDX6V

Aging is associated with lysosomal enlargement. Top left: Representative images of three different lysosomal morphologies in the hypodermis during aging. Top right: Ratio of animals exhibiting different lysosomal morphologies in the hypodermis during aging. Chi-square and Fisher’s exact test. n = 34–35 animals. Bottom: Working model of the regulation and function of lysosomal enlargement. Lysosomal enlargement occurs as a response to functional decline during aging. Upon lysosomal dysfunction, the transcription factor SKN-1 is activated to promote lysosomal enlargement by limiting fission in a BORC-dependent manner. This enlargement enhances lysosomal degradation capacity, serving as a beneficial adaptive response. In long-lived glp-1 mutants, SKN-1 activation similarly drives lysosomal enlargement, boosting degradation capacity and contributing to their extended life span.

Lysosomes are important for cellular degradation & signal transduction, but decline & change shape with age. This study shows that dysfunctional #aging #lysosomes undergo enlargement (promoted by the TF SKN-1) as a compensatory mechanism to sustain function @plosbiology.org 🧪 plos.io/4pjDX6V

Bentley-DeSousa, Roczniak-Ferguson and @shawnferguson.bsky.social reveal converging roles of STING and #lysosome damage in activating LRRK2 at #lysosomes via interactions between LRRK2 & GABARAP rupress.org/jcb/article/...

📕 From The Year In Cell Biology: rupress.org/jcb/collecti...
#CellBio2025

Homocysteine disrupts lysosomal function by V-ATPase inhibition, say Yang Yang, Qianjin Kong, Chaolian Liu, Mei Yang, Chonglin Yang and colleagues (Yunnan University): rupress.org/jcb/article/...

#Organelles #Metabolism #Lysosomes

Yang, Kong, Liu et al. report that homocysteine, an intermediate in methionine-cysteine #metabolism and the cause of the life-threatening disease #homocystinuria, disrupts lysosomal functions by binding to and homocysteinylating V-ATPase. rupress.org/jcb/article/...

#lysosomes

In @jcb.org, Yang, Kong, Liu et al. report that homocysteine, an intermediate in methionine-cysteine #metabolism and the cause of the life-threatening disease #homocystinuria, disrupts lysosomal functions by binding to and homocysteinylating V-ATPase. rupress.org/jcb/article/...

#lysosomes

Non-canonical roles of lysosomes in neurons Neurons are highly polarised and compartmentalised cells with organelles that are specialised to support their spatial and functional demands. This includes lysosomes, which are single-membrane-bound ...

Non-canonical roles of #lysosomes in neurons: Trends in Neurosciences www.cell.com/trends/neuro...

Direct measurements of luminal Ca²⁺ with endo-lysosomal GFP-aequorin reveal functional IP3 receptors. New study from Belén Calvo, Sandip Patel, Teresa Alonso @uva-es.bsky.social and colleagues: rupress.org/jcb/article/...

#Technology #Physiology #CellSignaling #Organelles #Lysosomes #Endosomes

A hidden cellular cleanup trick could reverse aging Researchers found that the body’s natural recycling system, the lysosome, plays a vital role in removing the protein that drives premature aging. When this system breaks down, aging speeds up. By reac...

Perhaps we need a cellular osmosis theory of aging to unify the cross-linkage theory of aging and the membrane theory of aging. #aging #lysosomes

www.sciencedaily.com/releases/202...

Calvo, Patel, Alonso @uva-es.bsky.social et al. describe a new bioluminescent sensor for measuring luminal Ca²⁺ in a mildly acidic subcompartment of the endo-lysosomal system. rupress.org/jcb/article/...

#CellSignaling #Organelles #Physiology #Technology #Lysosomes #Endosomes

In @jcb.org, Calvo, Patel, Alonso @uva-es.bsky.social et al. describe a new bioluminescent sensor for measuring luminal Ca²⁺ in a mildly acidic subcompartment of the endo-lysosomal system. rupress.org/jcb/article/...

#CellSignaling #Organelles #Physiology #Technology #Lysosomes #Endosomes

Delivering Progranulin to Astrocytic Lysosomes Promotes Growth of Co‐Cultured Neurons Loss-of-function progranulin (GRN) mutations cause frontotemporal dementia. Most of these mutations cause haploinsufficiency of progranulin, a secreted pro-protein that has neurotrophic and anti-infl...

Delivering Progranulin to Astrocytic #Lysosomes Promotes Growth of Co‐Cultured Neurons - Kaplelach - 2025 - Journal of Neurochemistry - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...