"These findings suggest a fundamental mechanism by which cancer cells may evade apoptosis by exploiting Bcl-2’s ability to neutralize Bax through structural entrapment, even if excess Bax is present, either in response to treatment or natural death signals." […]
Therapeutic potential of sustainable zinc oxide nanoparticles biosynthesized using Tradescantia spathacea aqueous leaf extract
Green-synthesized ZnO #Nanoparticles exhibit potent #Antibacterial & #AntiCancer activities through ROS-mediated #Apoptosis and cell cycle disruption, highlighting their potential in sustainable biomedical applications
Green Processing and Synthesis #OpenAccess: doi.org/10.1515/gps-...
Researchers identified CUDC-907, a dual PI3K/#HDAC inhibitor, to suppress #MEF2D fusion-driven BCP-ALL, inducing #Apoptosis and disrupting #Oncogenic signaling, highlighting its promise for precision therapy.
#STTT #OpenAccess: doi.org/10.1038/s413...
This study reveals that the SREBP-2 C-terminal fragment noncanonically drives IRAK1-dependent #Apoptosis, identifying a novel metabolic-apoptotic axis and a potential #TherapeuticTarget for #Sepsis-induced #Inflammation.
#OpenAccess: doi.org/10.1038/s413...
Green-synthesized silver nanoparticles from Syzygium aromaticum extract promote cancer cell death by targeting redox and inflammatory pathways
This #OpenChemistry study shows that Syzygium aromaticum-mediated green-synthesized silver #Nanoparticles induce #Apoptosis by targeting redox balance and inflammatory pathways, offering a green and effective approach for #Anticancer therapy.
#OpenAccess: doi.org/10.1515/chem...
MDM2-BCL-XL PROTACs
www.scienceopen.com/hosted-docum...
#PROTAC #MDM2 #BCLXL #Apoptosis #ProteinDegradation
Key Genes Involved in the Beneficial Mechanism of Hyperbaric Oxygen for Glioblastoma and Predictive Indicators of Hyperbaric Oxygen Prolonging Survival in Glioblastoma Patients
This study shows that #HBOTherapy exerts #Antitumor effects in #Glioblastoma, promoting #Apoptosis, inhibiting #Inflammation, reducing #CellProliferation, suppressing #TumorGrowth & #Metastasis, regulating #Vascularization, & thus prolonging patient survival. #medsky
Read: doi.org/10.1007/s115...
LncRNA NPTN-IT1-201 Ameliorates Depressive-like Behavior by Targeting miR-142-5p and Regulating Inflammation and Apoptosis via BDNF
This study finds that #lncRNA NPTN IT1 201 sponges #miR 142 5p, upregulates BDNF, reduces #Inflammation, #Apoptosis, & #Microglial activation, helping to alleviate depressive-like behavior, promising a potential #therapeutic target for MDD. #medsky
To read: doi.org/10.1007/s115...
Protective Effects of Berberine on Nonalcoholic Fatty Liver Disease in db/db Mice via AMPK/SIRT1 Pathway Activation
This study explores the hepatoprotective effects of #Berberine in #NAFLD, improving #InsulinResistance, lipid profiles, & #LiverInjury, while suppressing #OxidativeStress, #Inflammation, & #Apoptosis via activation of #AMPK/#SIRT1. #medsky
To read: doi.org/10.1007/s115...
Michael Acceptor Pyrrolidone Derivatives and Their Activity against Diffuse Large B-cell Lymphoma
In this study, the researchers spotlight the #Antitumor potential of variant 7 among synthesized pyrrolidone compounds in #DLBCL cell lines, which induces #DNAdamage, #Inflammatory responses, #CellCycle arrest, & #Apoptosis. #medsky
To read: doi.org/10.1007/s115...
Notopterygium Incisum Extract Promotes Apoptosis by Preventing the Degradation of BIM in Colorectal Cancer
This study identified Notopterygium incisum (QH) as a potent anti-#ColorectalCancer agent that induces #Apoptosis by preventing BIM protein degradation and activating the BIM/BAX axis both in vitro and in vivo. #Medsky
Read: doi.org/10.1007/s115...
Would you like to study membrane organization, dynamics, and cell death? 🧬 Check out the García-Sáez Group ( @office-garcia.bsky.social , @mpibp.bsky.social )
🗓 Application deadline: March 11 👉 imprs-cbp.mpg.de/call-for-app...
#imprs_cbp #membranebiophysics #apoptosis
Lindqvist-type Polyoxometalates Act as Anti-breast Cancer Drugs via Mitophagy-induced Apoptosis
A novel Lindqvist-type polyoxometalate MO-4 shows strong anti-breast cancer activity by raising #MitochondrialROS to trigger #mitophagy and #apoptosis, reducing #tumor growth and #metastasis in vivo, highlighting promise as a therapeutic candidate.
Read: doi.org/10.1007/s115...
Synergistic Effects of Glutamine Deprivation and Metformin in Acute Myeloid Leukemia
#Glutamine deprivation + metformin treatment inhibits AML cell proliferation & triggers #Apoptosis by suppressing mTOR signaling & increasing ROS levels, suggesting a dual metabolic targeting strategy to overcome #Chemoresistance.
Read: doi.org/10.1007/s115...
Researchers map the interplay of #ProgrammedCellDeath after #IschemicStroke, showing early #ferroptosis and #necroptosis followed by #apoptosis, with iron driving both—highlighting the potential of concurrently targeting multiple death mechanisms.
Read: doi.org/10.1016/j.ge...
Icariin Ameliorates D-galactose-induced Cell Injury in Neuron-like PC12 Cells by Inhibiting MPTP Opening
#Icariin ameliorates D-galactose-induced injury in neuron-like PC12 cells by blocking the abnormal mPTP opening, thereby suppressing #Autophagy, reducing #ROS generation, & mitigating #Apoptosis in a model of accelerated #Senescence.
Read: doi.org/10.1007/s115...
Combined MSC and Tβ4 therapy ameliorates #DryEyeDisease by inhibiting GLS1 to restore glutamine levels, and suppresses the IκBα/NF-κB signaling to protect corneal epithelial cells from #OxidativeStress-induced #Apoptosis.
#OpenAccess: doi.org/10.1038/s413...
USP19 Stabilizes TAK1 to Regulate High Glucose/Free Fatty Acid-induced Dysfunction in HK-2 Cells
#USP19 promotes high glucose– and fatty acid–induced kidney cell dysfunction by stabilizing TAK1, driving #apoptosis, mitochondrial stress, and PINK1/Parkin pathway disruption, highlighting USP19–TAK1 signaling as a target for #DiabeticNephropathy.
Read: doi.org/10.1007/s115...
👋Our February issue is out!
Cover: spatial #transcriptomics
👉Review: telomeric #chromatin
🔬 #mitochondria #mitophagy #senescence #p53 #epigenetics #glioblastoma #IDR #immunotherapy #cGASSTING #apoptosis #lysosomes & more!
www.nature.com/ncb/volumes/...
Fall in love with our trusted #redfluorescent stains and dyes! 💝
View our new RNaseReveal™ Red Activity Assay Kit: biotium.com/product/rnas...
#labhelp #synapticactivity #cellbiology #apoptosis #fluorescentchemistry #livecellimaging #molecularbiology, #labtools
Deadline today: abstract submission for the symposium on Multifaceted #Mitochondria - happening June in Glasgow. cell-symposia.com/mitochondria... #apoptosis
Antitumor Effect of Apcin on Endometrial Carcinoma via p21-Mediated Cell Cycle Arrest and Apoptosis
This study establishes CDC20 as a #TherapeuticTarget in #EndometrialCarcinoma, showing that its inhibitor, #Apcin, suppresses proliferation and induces #Apoptosis & cell cycle arrest, by activating the BBC3/caspase-3 pathway & enhancing p21 expression.
Read: doi.org/10.1007/s115...
Recombinant #Wnt2 protects against #IschemiaReperfusionInjury by promoting Lrp6/Trim11-mediated Nap1L1 degradation, restoring antioxidant gene expression, reducing #ROS, and limiting #cardiomyocyte #apoptosis and #ferroptosis. @FudanUniversity
#STTT: doi.org/10.1038/s413...
Biogenic synthesized selenium nanoparticles combined chitosan nanoparticles controlled lung cancer growth via ROS generation and mitochondrial damage pathway
#Greensynthesis of selenium and selenium–chitosan #nanoparticles using #GrapeSeedExtract demonstrates selective, dose-dependent #cytotoxicity in lung cancer cells via #ROS-mediated mitochondrial dysfunction and #apoptosis. #anticancer
Nanotechnology Reviews: doi.org/10.1515/ntre...
Anticancer and anti-inflammatory potentials of doped CuO and ZnO nanoparticles: a multi-pathway mechanistic study
Dopant-engineered Y–CuO and Ag–ZnO #Nanoparticles promotes #Cuproptosis-like #Apoptosis & enhances ROS-mediated #OxidativeDamage, providing a dual-action mechanism for targeted #TumorSuppression and anti-inflammatory activity.
Open Chemistry #OpenAccess: doi.org/10.1515/chem...
TRPC6 Knockout Alleviates Renal Fibrosis through PI3K/AKT/GSK3B Pathway
TRPC6 knockout alleviates #RenalFibrosis by reducing fibrotic markers, #apoptosis, and #inflammation, while downregulating the PI3K/AKT/GSK3β pathway—supporting TRPC6 inhibition as a promising therapeutic strategy for #ChronicKidneyDisease.
Read more: doi.org/10.1007/s115...
Crosstalk among Oxidative Stress, Autophagy, and Apoptosis in the Protective Effects of Ginsenoside Rb1 on Brain Microvascular Endothelial Cells: A Mixed Computational and Experimental Study
#Ginsenoside Rb1 protects BMECs from #Ischemia-reperfusion injury by regulating #Autophagy, #Apoptosis, and #OxidativeStress via SQSTM1/p62, ATG5, and HIF-1α, highlighting these as potential #TherapeuticTargets for #IschemicStroke.
Read: doi.org/10.1007/s115...
We are proud to celebrate all the research advancing #cancersolutions today, and beyond.
View our innovative tools to benefit your #cancerresearch here: biotium.com/products/can...
#worldcancerday #cancerawareness #globalhealth #labhelp #dna #apoptosis #fightcancer #fluorescencemicroscopy
This review analyzes #LIPUS as a #noninvasive therapy for #PrematureOvarianInsufficiency, highlighting its roles in modulating cell proliferation, #apoptosis and #angiogenesis, while exploring combination strategies and future prospects for restoring #ovarian function.
Read: url-shortener.me/AW7B
MAFB and #CEBPA promote #urothelial growth, and their reduced expression in #hypospadias reveals a pathogenic mechanism whereby MAFB knockdown suppresses CEBPA, inhibits #Wntβcatenin signaling, arrests the #cellcycle, and induces #apoptosis.
#OpenAccess: doi.org/10.1016/j.ge...
