Cardiac regeneration: Pre-existing cardiomyocyte as the hub of novel signaling pathway
This review highlights endogenous modulators—TFs, ncRNAs, cyclins, and kinases—as regulators of #cardiomyocyte proliferation, offering insights into awakening #HeartRegeneration pathways and advancing therapies for cardiovascular disease.
#OpenAccess: doi.org/10.1016/j.ge...
m6A-modified circArhgap26 attenuates cardiac I/R injury by suppressing plakophilin-1 palmitoylation, maintaining desmosome integrity and #Cardiomyocyte survival, offering a novel #TherapeuticTarget in #MyocardialInjury.
#STTT #OpenAccess: doi.org/10.1038/s413...
Recombinant #Wnt2 protects against #IschemiaReperfusionInjury by promoting Lrp6/Trim11-mediated Nap1L1 degradation, restoring antioxidant gene expression, reducing #ROS, and limiting #cardiomyocyte #apoptosis and #ferroptosis. @FudanUniversity
#STTT: doi.org/10.1038/s413...
Cardioprotective Potential of Cymbopogon citratus Essential Oil against Isoproterenol-induced Cardiomyocyte Hypertrophy: Possible Involvement of NLRP3 Inflammasome and Oxidative Phosphorylation Complex Subunits
#CymbopogonCitratus #EssentialOil inhibits #Isoproterenol-induced #cardiomyocyte hypertrophy by suppressing #NLRP3Inflammasome signaling and modulating oxidative phosphorylation complex subunits, highlighting its cardioprotective potential. #CVD
Read: doi.org/10.1007/s115...
🫀 Up-scaling the differentiation of functional cardiomyocytes using different bioreactors - a key area of research for our team! Interested on collaborating on this together?
Get in touch: ebisc.org/contact
#iPSC #StemCell #Cardiac #Cardiomyocyte
New #cardiomyocyte research maps temporal alternative splicing regulation during cardiac regulation and uncovers altered splicing events in iPSC-cardiomyocytes, providing insights into the limitations of these models in cardiovascular research. https://ow.ly/kr4550XSzCS
#PDE4DIP is identified as a driver of #LeftVentricularNoncompaction; its overexpression disrupts #cardiomyocyte polarity and energy metabolism, while knockdown restores #ATP and migration, highlighting new therapeutic targets for LVNC.
#OpenAccess: doi.org/10.1016/j.ge...
Impact of peroxisomal biogenesis protein PEX11a deficiency on cardiomyocyte structure and cardiac function in a mouse model. #cardiomyocyte #peroxisome #ischemia #oxidativestress #lipidmetabolism #MALDIMSI
www.mdpi.com/2073-4409/15...
#AngiotensinII #Cardiomyocyte #Ferroptosis #AtrialFibrillation
AAV-expressed GSTP1, GST isoenzyme, rescues ANGII-cardiomyocyte
#LipidPeroxidation
#MitochondrialDysfunction
#Ferroptosis
🫀Fibrosis
Susceptibility to electrical AF
#Europace 2025 @escardio.bsky.social
academic.oup.com/europace/art...
Restoring the connection between the #heart and the right #VagusNerve prevents #CardiacAging by preserving #cardiomyocyte health and promoting #HeartLongevity independently of #HeartRate.
💓 Scientists with Dr. Nobuaki Fukuma at @columbiauniversity.bsky.social investigated whether and how #cardiomyocyte NO-sensitive soluble guanylyl cyclase mediates female-specific, adaptive right ventricular pressure-overload remodeling.
👉 https://bit.ly/3WYQdx2
This review highlights how #mtDNA integrity influences #Cardiomyocyte injury in #Ischemia/#Reperfusion and explores therapeutic approaches that target #mtDNA to protect the #Heart. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
New work from Nicole S. York and the group of Leigh Anne Swayne at the University of Victoria charts how #H9c2 heart cells change shape, signal, & express genes during differentiation—revealing both their promise & limits as #cardiomyocyte models.
#CardioSky
sciencedirect.com/science/arti...
ZBP1 drives #Cardiomyocyte #PANoptosis via the ZBP1/RIPK3/CASP6/CASP8 complex, with cardiomyocyte-specific Zbp1 deficiency reducing #Myocardial I/R injury, while the small molecule MSB targets ZBP1 to mitigate damage. @fudan-university.bsky.social
#STTT: doi.org/10.1038/s413...
Divergent TPM1 mutants in #HypertrophicCardiomyopathy (E62Q) vs #DilatedCardiomyopathy (E54K)
#hiPSC #Cardiomyocyte
Engineered heart tissue
Twitch kinetics
Diastolic stiffness
RNAseq/Proteomics
E62Q⬇️effective stiffness
E54K⬆️Tropomyosin–troponin I interaction
#JCI 2024
www.jci.org/articles/vie...
#Doxorubicin-treated #BreastCancer cells release #exosomal miR-216a-5p, which suppresses ITCH, stabilizes TXNIP, and activates the NLRP3 inflammasome to trigger #cardiomyocyte #pyroptosis. #cardiotoxicity @fudan-university.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
Another monthly COE meeting funded by the @novo-nordisk.bsky.social was held, highlighting the research done by Carmo-Fonseca and Tom Kirchhausen lab.
The theme for today was to explore the #ASO, synthesized in KJJ’s lab, uptake in #cardiomyocyte cells along with understanding #endosomalescape.
Ayako Takeuchi & Satoshi Matsuoka performed a simulation study on the role of #mitochondria-sarcoplasmic reticulum Ca2+ interaction in #cardiomyocyte energetics during exercise 🏃 🔬
📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
In @jgp.org, Sun, Loftus, Kekenes-Huskey et al. provide a new lens to understand dynamic control and dysfunction in #cardiomyocyte contraction via an understanding of ABLIM1 and the complexities of its phosphorylation and interactions in the #sarcomere. rupress.org/jgp/article/...
Sun, Loftus, Kekenes-Huskey et al. @loyolachicago.bsky.social provide a new lens to understand dynamic control and dysfunction in #cardiomyocyte contraction via an understanding of ABLIM1 and the complexities of its phosphorylation and interactions in the #sarcomere. rupress.org/jgp/article/...
Congrats to Gurpreet Kaur, on a successful MSc. defence. Incredibly proud of Gurpreet for a thesis well done, examining the role of #TFE3 in #cardiomyocyte #metabolism and function. Thanks to the examining and supervisory research committee for their feedback @dalhousieu.bsky.social
A new video showcasing our Calcium and Contractility Mapping System on iPSC-CMs. It enables simultaneous, high-res measurement of Ca transients and contractility with advanced mapping features.
#cardiomyocyte #singlecell #mapping #calcium #electrophysiology #cardiology #ipsc
Use of a cell-based #mathematical model of #cardiac #electrophysiology to assess effects of #cardiomyocyte cell variability predicts reduced #gapjunction #cell coupling to amplify cardiomyocyte variability and destabilise the #heartbeat
This study confirms the critical role of #KetoneMetabolism in myocardial hypoxia by showing that #hypoxia promotes elevated expression of the #cardiomyocyte ketone body-metabolizing enzymes SCOT/OXCT1, ACAT1, and BDH2 and decreases the levels of #succinylCoA. #medsky.
Read more: buff.ly/38Y5ufa
The Lymphatic Vasculature in Cardiac Development & Ischemic Heart Disease
#Lymphoangiocrine #Reelin▶️#Integrinβ1 #Cardiomyocyte
🫀development & regeneration post-cryoinjury/-MI
@lforlymphatics.bsky.social @lymphaticsprox1.bsky.social #CircRes 2023
www.ahajournals.org/doi/10.1161/...
Hatzakis, KJJ, Kirchhausen and Carmo-Fonseca lab online on zoom.
KJJ and Hatzakis lab at the University of Copenhagen.
One more monthly COE meeting funded by the NNF Challenge Programme was held.
We discussed how material synthesized by KJJ lab are evaluated by all 3 groups and how #MachineLearning analysis by Hatzakis lab can propel #cardiomyocyte research of Carmos-Fonseca lab.
Work in our April issue offers a detailed cardioFISH protocol for #cardiomyocyte nuclear ploidy assessment.
Available open access: doi.org/10.1016/j.yj...
Such a pleasure to have Hanan from @ionoptix.bsky.social to come to FSU to help us setup this Ca2+ and contrqctility system to assess #cardiomyocyte function 🔬🧫🫀
RBPMS (splicing factor)-CreERT2 mice
Active in a broad collection of cell types, incld #SmoothMuscleCell #Pericyte #Cardiomyocyte & more & more
@cp-iscience.bsky.social 2023
www.cell.com/iscience/ful...
Check out our latest episode!
Dr. Robert Zweigerdt from Hannover Medical School joined us for a great conversation about #cardiomyocyte differentiation and heart-forming #organoids!
Listen now: bit.ly/41JaMkg
