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SMASH-HCM Project: WP3 Highlights Cardiac Cell Biology and Digital Twin Development | SMASH-HCM posted on the topic | LinkedIn 📚🌟Over the next few weeks, we will be presenting the work we are doing within the SMASH-HCM project. Each week will highlight a different Work Package (WP), explaining what is being done and showcasin...

We have started a new educational series on our LinkedIn page. Each week we will present our Work Packages, explaining what is being done and showcasing our amazing partners! Click the link for the first post. www.linkedin.com/feed/update/...
#HCM #HypertrophicCardiomyopathy

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Two histograms show frequency distributions. (A) Income distribution, peak around $63033, mean income of study population $90261. (B) SDI distribution, peak near 0, mean SDI population residing in respective cities 75.5, study population 34.2.

Two histograms show frequency distributions. (A) Income distribution, peak around $63033, mean income of study population $90261. (B) SDI distribution, peak near 0, mean SDI population residing in respective cities 75.5, study population 34.2.

In the Sarcomeric Human Cardiomyopathy Registry, lower household income and higher social deprivation index were each associated with higher rates of heart failure, arrhythmias, and mortality in #HypertrophicCardiomyopathy.

ja.ma/46i75nu

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SMASH-HCM Highlights from 2025 Below is a showcase of selected highlights:

Last year was a very productive year for #SMASH-HCM! Check out our latest article on our website to read about selected highlights from 2025. smash-hcm.eu/news/highlig... #HypertrophicCardiomyopathy #HCM

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Social Determinants of Health and Clinical Outcomes in Hypertrophic Cardiomyopathy This cohort study using data from the Sarcomeric Human Cardiomyopathy Registry determines the association of area-based social determinants of health with clinical outcomes in patients with hypertroph...

How your neighborhood modulates genetically determined disease risk jamanetwork.com/journals/jam... #HypertrophicCardiomyopathy #HCM #TranslationalScience

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Management of hypertrophic cardiomyopathy Cardiomyopathies are primary heart muscle disorders in which the observed structural and functional abnormalities are not explained by coronary artery disease (CAD), hypertension, valvular disease or…

This week's learning article outlines pharmacological treatment approaches for hypertrophic cardiomyopathy, including #pharmacogenomic considerations for first-in-class myosin inhibitors

#hypertrophiccardiomyopathy #cardiology #cardiovascularhealth

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Thank you for joining our consortium meeting! 🤝 We are looking forward to continue our collaboration.
#HypertrophicCardiomyopathy #DigitalTwin

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Figure 4 shows two histograms comparing income and SDI. Graph A: Income, plots frequency vs income, with mean incomes of $63033 and $90261. Graph B: SDI, plots frequency vs SDI, with mean SDI of 75.5 and 34.2.

Figure 4 shows two histograms comparing income and SDI. Graph A: Income, plots frequency vs income, with mean incomes of $63033 and $90261. Graph B: SDI, plots frequency vs SDI, with mean SDI of 75.5 and 34.2.

In the Sarcomeric Human Cardiomyopathy Registry, lower household income and higher social deprivation index were each associated with higher rates of heart failure, arrhythmias, and mortality in #HypertrophicCardiomyopathy.

ja.ma/45H74ZX

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GSK closes on approval of asthma hope depemokimab GSK is poised for the first major approval of depemokimab, a long-acting drug for severe asthma that can be dosed just twice a year.

#GSK #depemokimab #severeasthma #Exdensur #CRSwNP #respiratory #immunology #inflammation #Nucala #mepolizumab #COPD #rarediseases #SerumLifeScienceEurope #Anktiva #NMIBC #SFLPharma #Aumseqa #NSCLC #Cytokinetics #Myqorzo #hypertrophiccardiomyopathy #Moderna #Mnexspike #COVID19vaccine
zurl.co/l8WfN

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Case Report: NF1-Associated Hypertrophic Cardiomyopathy A young man with signs of heart failure was simultaneously diagnosed with both NF1 and hypertrophic cardiomyopathy.

A young man was simultaneously diagnosed with neurofibromatosis type 1 (#NF1) and #HypertrophicCardiomyopathy, highlighting how these 2 conditions often overlap. This case report was published in Circulation.

Read more: https://bit.ly/3XyxMiZ

#RareDisease #Cardiology #MedSky

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Divergent TPM1 mutants in #HypertrophicCardiomyopathy (E62Q) vs #DilatedCardiomyopathy (E54K)

#hiPSC #Cardiomyocyte
Engineered heart tissue
Twitch kinetics
Diastolic stiffness
RNAseq/Proteomics

E62Q⬇️effective stiffness
E54K⬆️Tropomyosin–troponin I interaction

#JCI 2024
www.jci.org/articles/vie...

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The HCMA will hold its Annual Patient Meeting and Gala on October 18 in Morristown, NJ, at the Hyatt Regency Hotel. Register early to reserve your place.
Register Here: buff.ly/j0HqpxN
#HCM #AnnualPatientMeeting #HypertrophicCardiomyopathy #RegistrationIsOpen

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The HCMA would like to highlight PennState Health.

Thank you to HCM Program Director Eric Popjes, MD.

View PennState Health's directory listing page for more information about the center. www.4hcm.org/coe/penn

#4hcm #CenterOfExcellence #COE #Hypertrophiccardiomyopathy #PennStateHealth

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Making Medicine: The First Precision Medicine for a Genetic Heart Disease
Making Medicine: The First Precision Medicine for a Genetic Heart Disease People with hypertrophic cardiomyopathy (HCM) — often an inherited disease marked by abnormally thickened heart muscle — face a looming risk of heart failure, arrhythmia, and sudden cardiac arrest.…

New, emerging treatments for #HypertrophicCardiomyopathy. #Genesprout screens for increased risk of #HCM, leading cause of sudden cardiac death in young athletes. #SCD #athletes #children

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The HCMA would like to highlight Houston Methodist!
Thank you to HCM Program Director Sherif F. Nagueh, MD
View Houston Methodist's directory listing page for more information about the center. www.4hcm.org/coe/methodist
#4hcm #CenterOfExcellence #COE #Hypertrophiccardiomyopathy #HoustonMethodist

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The HCMA would like to highlight Scripps Clinic.

Thank you to HCM Program Jorge Gonzalez, MD.

Visit 4hcm.org to find an HCMA Recognized Center of Excellence near you.

#4hcm #CenterOfExcellence #COE #Hypertrophiccardiomyopathy #ScrippsClinic

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The HCMA is a proud partner of Atrium Health Sanger Heart and Vascular.

Click here to view Atrium Health’s directory listing page and get more information about the center. www.4hcm.org/coe/atrium-2

#4hcm #CenterOfExcellence #COE #Hypertrophiccardiomyopathy #AtriumHealth

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The HCMA will hold its Annual Patient Meeting and Gala on October 18 in Morristown, NJ, at the Hyatt Regency Hotel. Register early to reserve your place.
Register Here: buff.ly/j0HqpxN
#HCM #AnnualPatientMeeting #HypertrophicCardiomyopathy #RegistrationIsOpen

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Rising ROS levels trigger #Mitochondrial damage & activate the PI3K/AKT/FOXO3a axis, boosting #OxidativeStress in #HypertrophicCardiomyopathy (HCM), suggesting that ROS dynamics may offer novel #therapeutic targets for HCM. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

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The HCMA would like to highlight the University of Utah!
Thank you to the HCM team at the University of Utah Health.
Visit 4hcm.org to find an HCMA Recognized Center of Excellence near you.

#4hcm #CenterOfExcellence #COE #Hypertrophiccardiomyopathy #UniversityofUtah

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The HCMA would like to highlight UVA Health.

Click here to view UVAHealth’s directory listing page and get more information about the center. www.4hcm.org/coe/virginia

#4hcm #CenterOfExcellence #COE #Hypertrophiccardiomyopathy #UVAHealth

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The HCMA would like to highlight UCSF Health.

Theodore Abraham, MD is the 2024- 2025 American Society of Echocardiography (ASE) President. Both him and Roselle Abraham, MD published a abstract on the role of imaging and diagnosis.
#4hcm #CenterOfExcellence #COE #Hypertrophiccardiomyopathy

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How lucky are we with Dr Carolyn Ho joining us in Brisbane for #CSANZ2025 highlighting some of the challenges with new therapy options in #hypertrophiccardiomyopathy from this beautiful new review! www.cell.com/cell/abstrac... @sharday-penn.bsky.social

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The HCMA would like to highlight Westchester Medical Center. Congratulations to Srihari S. Naidu, MD, on his inauguration as the 48th President of the Society for Cardiovascular Angiography & Interventions (SCAI).
#4hcm #CenterOfExcellence #COE #Hypertrophiccardiomyopathy #WestchesterMedicalCenter

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The HCMA would like to highlight UCLA Health.

Click here to view UCLA Health’s directory listing page and get more information about the center. www.4hcm.org/coe/ucla

#4hcm #CenterOfExcellence #COE #Hypertrophiccardiomyopathy #UCLAHealth

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The HCMA would like to highlight the team at the University of Kansas Health.
Click here to view the University of Kansas Health’s directory listing page and get more information about the center. www.4hcm.org/coe/kansas
#CenterOfExcellence #Hypertrophiccardiomyopathy #TheUniversityofKansasHealth

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Diagnostic Role of Wall Thickness Heterogeneity in Hypertrophic Cardiomyopathy and in Carriers of Sarcomeric Gene Mutations
Ait-Ali, L., Alberti, M. et al.
Paper
Details
#HypertrophicCardiomyopathy #SarcomericGeneMutations #WallThicknessHeterogeneity

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The HCMA will hold its Annual Patient Meeting and Gala on October 18 in Morristown, NJ, at the Hyatt Regency Hotel. Register early to reserve your place.
Register Here: buff.ly/j0HqpxN
#HCM #AnnualPatientMeeting #HypertrophicCardiomyopathy #RegistrationIsOpen

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The HCMA would like to highlight UCLA Health.

Click here to view UCLA Health’s directory listing page and get more information about the center. www.4hcm.org/coe/ucla

#4hcm #CenterOfExcellence #COE #Hypertrophiccardiomyopathy #UCLAHealth

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Earlier this year, the HCMA welcomed Piedmont Heart to the HCMA COE Program.

We applaud Piedmont's work in advancing patient care and research.

View Piedmont Heart's directory listing page for more information about the center. www.4hcm.org/coe/piedmont

#4hcm #COE #Hypertrophiccardiomyopathy

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Registration for the HCMAs Annual Patient Meeting and Gala is now open!
This event will be held on October 18th in Morristown, NJ, at the Hyatt Regency Hotel. Register early to reserve your place.
Register Here: buff.ly/j0HqpxN
#HCM #AnnualPatientMeeting #HypertrophicCardiomyopathy

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