JCI Insight - CD9 regulates macrophage-mediated remodeling of adipose tissue in obesity

CD9 as promising therapeutic target to modulate pathogenic #AdiposeTissue #Macrophages activity while preserving essential homeostatic functions insight.jci.org/articles/vie... @drdavidhill.bsky.social #Obesity #MetabolicDisease #TranslationalScience

Welcome! You are invited to join a meeting: Digital Health and Informatics at UC Davis Seminar Series: Tools for Mobile Health and Agentic Chatbot Research. After registering, you will receive a confi... The Digital Health and Informatics at UC Davis: Advancing Research and Real-World Practice is a seminar series highlighting tools, services, resources, and projects across UC Davis that support transl...

Digital Health & Informatics Seminar Series:
Tools for Mobile Health and Agentic Chatbot Research

📅 April 16, 2026
⏰ 12–1:30 p.m. PST
💻 Zoom

Explore mobile health tools and agentic chatbot research with Amir M. Rahmani.

🔗: ucdavishealth.zoom.us/meeting/regi...

#TranslationalScience

New findings show STEAP4 plays a key role in liver recovery after acetaminophen injury by maintaining lysosomal iron balance and function—pointing to new treatment strategies.

WSU EACPHS #LiverResearch #TranslationalScience

doi.org/10.1097/hep....

Society for Humanities, Social Science, and Medicine

The 11th Biennial SHSSM Conference will take place April 11–12 at UCSF Mission Bay, San Francisco!

Theme: Living Questions: Theory, Practice, and Activism in a Time of Reckoning.

Learn more and register: shssm.net

#TranslationalScience

Dr. Nathan Bryan interviews nitric oxide research pioneer Prof. Jack Lancaster

Be part of the movement bridging science and application.
no2026.com

#NO2026 #HealthEducation #TranslationalScience #MedicalInnovation #KnowledgeToAction #FutureOfMedicine

Dr. Nathan Bryan interviews nitric oxide research pioneer Prof. Jack Lancaster

Be part of the movement bridging science and application.
no2026.com

#NO2026 #HealthEducation #TranslationalScience #MedicalInnovation #KnowledgeToAction #FutureOfMedicine

AP-1 mediates cellular adaptation and memory formation - Nature Communications Cellular responses to stimuli can involve learned behaviors through memory formation. Here, the authors show that cancer cells encode gene expression into cellular memories during therapy resistance v...

Untangling mechanisms underlying #CancerDrugResistance www.nature.com/articles/s41... @jess_ljx @arjunraj.bsky.social #Cancer #DrugResistance #TranslationalScience

Structures of nucleotide-bound Redondovirus Rep protein link conformation and function Author summary We have used cryo-electron microscopy and solution biophysical techniques to understand the structure of the Rep protein from a Redondovirus, a CRESS DNA virus originally found in human...

Characterizing high resolution structures of #Redondovirus Rep proteins doi.org/10.1371/jour... #Virology #InfectiousDisease #TranslationalScience

fatigue, weakness, swallowing difficulties, and the invisible labour of navigating complex care pathways.

🎙️ Link: youtu.be/bkk_okQ3mtk

#AutoimmuneDisease #RareDiseaseResearch #PatientPartners #TranslationalScience

🧵 End

New thinking in drug R&D tackling intractable scientific challenges—reshaping therapeutic innovation
www.scienceopen.com/hosted-docum...
#DrugDiscovery #R&D #PharmaInnovation #TranslationalScience

PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Leveraging #Polymorphism data as reliable proxy to map mutation patterns across 108 #Eukaryotic species www.pnas.org/doi/10.1073/... @bvoight28 #Methylation #CpG #GxEinteraction #TranslationalScience

Statistical Methods in Clinical and Translational Research Statistical Methods in Clinical and Translational Research: From Efficient Trial Design to Modeling Complex Data for Biological Insight This talk will highlight how principled statistical methods can…

Statistical Methods in Clinical and Translational Research | Apr. 9

Kathy Zhou, PhD, MS, will highlight how principled statistical methods can strengthen clinical and translational research. Register now:

buff.ly/tUHI0AA

#URochesterResearch #CTSA #TranslationalScience #GrandRounds

2026 SIRS Outstanding Translational Research Award 🏆

Congratulations to Carrie Bearden, Ph.D., recipient of the Outstanding Translational Research Award.

We look forward to celebrating Dr. Bearden at #SIRS2026 in Florence.

#TranslationalScience #SchizophreniaResearch

Intestinal interoceptive dysfunction drives age-associated cognitive decline - Nature Age-related microbiome changes increase medium-chain fatty acid-producing bacteria, driving GPR84-mediated myeloid inflammation, impaired vagal signalling and hippocampal dysfunction; targeting this g...

Age-related inhibition of #GutBrainSignaling reduces hippocampal activity and impairs #MemoryEncoding doi.org/10.1038/s415... #Aging #Microbiome #TranslationalScience

Predictive biomarkers of response to chimeric antigen receptor (CAR) T-cell therapy for pan-haematologic cancer - Nature Biomedical Engineering A pan-haematologic cancer approach, involving analysis of data from 256 patients across 5 cancer types and 13 clinical trials, revealed predictive biomarkers for understanding the response or non-resp...

Leveraging #ComputationalBiology at scale to individualize #Immunotherapy: www.nature.com/articles/s41... @JoeFraietta @carlhjune #CARTcelltherapy #CellTherapy #CARTCell #TranslationalScience

CTSC staff member stands behind a UC Davis Clinical and Translational Science Center outreach table with informational materials, pens, and a prize wheel during the UC Davis Principles of Community celebration.

A walkway outside the Betty Irene Moore School of Nursing lined with international flags representing diverse cultures during the Principles of Community celebration.

A DJ plays music in the atrium of the Betty Irene Moore School of Nursing while international flags and artwork decorate the space during the event.

A small rubber duck wearing sunglasses is held up outdoors on the UC Davis Health campus lawn.

🎉Celebrating 36 years of the UC Davis Principles of Community!🎉

On March 3, CTSC staff joined colleagues at the Betty Irene Moore School of Nursing to celebrate the cultures and communities that shape our workplace and the people we serve!

#TranslationalScience #CTSC #Community

Generative Artificial Intelligence: Implications for Families and Pediatricians Generative artificial intelligence (AI) technologies, capable of producing original text, images, audio, and video, are increasingly embedded in children’s learning, play, and daily life. Pediatric clinicians and parents face the challenge of guiding children toward safe and constructive engagement with these rapidly evolving tools. This state-of-the-art review synthesizes current knowledge regarding opportunities, risks, and best practices related to children’s interactions with generative AI. Developmental considerations are emphasized because the impact of AI varies across early childhood, middle childhood, and adolescence. We highlight potential benefits, including personalized learning, creative expression, and enhanced communication, while also discussing risks such as misinformation, privacy threats, and false perceptions of AI as a friend or caregiver. Evidence-based strategies are proposed to promote AI literacy, critical thinking, and safe integration of AI into pediatric care and education.

Charting a course toward meaningful #AIliteracy in #PediatricCaregiving doi.org/10.1542/peds... #AI #MediaLiteracy #GenerativeArtificialIntelligence #TranslationalScience

Redirecting

Optimizing #CRISPR for #FunctionalGenomics in patient-derived #Xenograft and primary #AcuteMyeloidLeukemia w/ diverse #PathogenicMutations doi.org/10.1016/j.mo... @junwei_s #AML #TranslationalScience

Airtable | Everyone's app platform Airtable is a low-code platform for building collaborative apps. Customize your workflow, collaborate, and achieve ambitious outcomes. Get started for free.

Discover the Power of DAVE: A Researcher’s Guide to Databricks
📅 March 20, 2026
⏰ 1–2 p.m.
💻 Zoom

Learn how DAVE and Databricks can accelerate research workflows, simplify data management, and help extract insights from complex data!

🔗 Register: airtable.com/appPzowN8ekL...

#TranslationalScience

Interbreeding between Neanderthals and modern humans was strongly sex biased Sex biases in admixture and other demographic processes are recurrent features throughout human evolution. For admixture between Neanderthals and anatomically modern humans (AMHs), sex bias has been p...

Novel insight into where the #Neanderthal DNA that persists in people today comes from: www.science.org/doi/10.1126/... @sarahtishkoff.bsky.social #PaleoGenomics #EvolutionaryBiology #TranslationalScience

Loading SumTotal

📢 ILT Class: Stem Cell Oversight in Research
📅 Feb 26, 2026
⏰ Noon–1:30 p.m. PST
🎤 Alaisha Hellman

Learn about protocol approval, SCRO disclosures, RECO review, and the SCRO Committee’s role.

🔗 Advanced LMS registration required:
uc.sumtotal.host/rcore/c/pill...

#TranslationalScience #CTSC

Serum Endogenous Opioid Levels are Associated with Self-Injury Severity in Adolescents with Non-Suicidal Self-Injury and Comorbid Depression - Neuroscience Bulletin Neuroscience Bulletin -

Ding et al. identified reduced serum beta-endorphin as a core biological signature of adolescent non-suicidal self-injury. #MentalHealthResearch #TranslationalScience See here: doi.org/10.1007/s122...

Art as a multiplier of science communication | Journal of Clinical and Translational Science | Cambridge Core Art as a multiplier of science communication - Volume 10 Issue 1

Reimagining scientific communication using art as a tool for the next generation of translational scientists doi.org/10.1017/cts.... @carstenskarke.bsky.social #ITMATEd #ScienceCommunication #SciComm #SciArt #WorkforceDevelopment #TranslationalScience

The Thymus Regeneration Paradox: The Search for Stemness in an Involuting Organ The thymus is emerging as a model for studying organ regeneration and stem cell biology. While research has long focused on how antigen-presenting cells shape the T cell repertoire, recent discoverie....

👀 Our latest review is out in Immunological Reviews.

We revisit the search for #stemness in an involuting organ - and the paradox at the heart of #thymus biology 💡

#Thymus #StemCells #Regeneration #Immunology #TranslationalScience #OrganReconstruction @crick.ac.uk @ucl.ac.uk

shorturl.at/u6xJK

Depression of tryptophan may contribute to adverse effects of naproxen - Nature Communications Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) have been associated with adverse effects affecting both the cardiovascular and gastrointestinal systems. Here the authors show that NSAIDs lower plasma ...

#Tryptophan supplementation may attenuate #Naproxen adverse effects and widen its #TherapeuticIndex www.nature.com/articles/s41... @FitzGerald__Lab #Pharmacology #DrugMechanism #DrugSafety #TranslationalScience

Bile acid analogs targeting C. difficile spore germination safely altered bile acid homeostasis in vivo — supporting prophylactic development.

Research from WSU EACPHS.

#ClostridioidesDifficile #TranslationalScience

doi.org/10.3390/biom...

Wellbeing International Foundation backs cell-free regenerative therapy aimed at restoring the body’s repair language.

vist.ly/4rw22

#longevity #RegenerativeMedicine #CellFreeTherapy #Biotechnology #HealthyAging #TissueRepair #NextGenMedicine #TranslationalScience

Advance research in immune-mediated inflammatory diseases and beyond by submitting your work to Signal Transduction and Targeted Therapy.
mts-sigtrans.nature.com
#ImmunologyResearch #TranslationalScience

DPUK’s focus: building “complex knowledge” — integrating imaging, genomics, biomarkers, trials and AI etc., within shared research architectures. Connecting these disciplines is a force multiplier for #dementia discovery. #DementiaResearch #TranslationalScience
zurl.co/oKkaN

Sleep-dependent clearance of brain lipids by peripheral blood cells - Nature Peripheral macrophage-like haemocytes in Drosophila promote sleep by clearing lipid buildup in the brain, helping to maintain metabolic homeostasis and brain function and fitness.

#Drosophila model updates our understanding of brain–periphery interactions: www.nature.com/articles/s41... @amitaseh #BrainHealth #Neurobiology #SleepResearch #Neuroscience #TranslationalScience