JCI Insight - CD9 regulates macrophage-mediated remodeling of adipose tissue in obesity

CD9 as promising therapeutic target to modulate pathogenic #AdiposeTissue #Macrophages activity while preserving essential homeostatic functions insight.jci.org/articles/vie... @drdavidhill.bsky.social #Obesity #MetabolicDisease #TranslationalScience

This review highlights how NAD⁺/NADH and NADP⁺/NADPH homeostasis—regulated by NAD kinases, MESH1, NOCT, and circadian control—governs cellular metabolism and redox balance, with dysregulation linked to #cancer and #MetabolicDisease. #Nocturnin

#OpenAccess: doi.org/10.1016/j.ge...

Yes!! Thank you for mentioning GLP-1’s are more than “weight loss meds!” They have been found to improve PASC fatty livers, treat obstructive sleep apnea, treat certain addictions, & IMHO will soon be key to finally having a tx for #metabolicdisease. We just need the #FDA to know this!!

📽️Film: ‘Rare Metabolic Diseases – Advancing Understanding, Improving Outcomes’

Watch now for FREE ⬇️
progress.org.uk/film-rare-me...

#MakeRareFair #MetabolicDisease #RareDisease #Health #Treatment #HealthSupport #NHS #Diagnosis #InheritedDisease #MetabolicSupportUK #DNA #Genetics

GLP-1 isn’t a miracle.

It’s a metabolic tool.

Without muscle preservation and long-term strategy, weight loss rebounds.

Obesity is metabolic disease — not a character flaw.

#GLP1 #MetabolicDisease #ObesityCare

Diabetes research highlights from Signal Transduction and Targeted Therapy, spanning disease mechanisms, complications, and emerging therapeutic strategies.
www.nature.com/sigtrans/
#DiabetesResearch #MetabolicDisease #SignalTransduction #TranslationalMedicine

#HealthCare rant: calling all insurers and doctors: #MetabolicDisease or #InsulinResistance is a real, codable disease process! It is right there in the name!! Why would you deny a medication that reverses post- #Covid #non-alcoholicfattyliverdisease, #T2Diabetes, ⬇️my #lipids, ⬇️my #A1-C & reduces

#Targetome
Targeting neddylation shows promise for metabolic disease treatment. Fine-tuning cullin 3 activity key for safe, effective therapies. 🔬💊
Details: www.maxapress.com/article/doi/10.48130/tar...
#metabolicdisease #promise #therapy #targeting

RANT: Just found out I “no longer qualify” for my Rx that has been the Only thing that is controlling my #metabolicdisease #insulinresistance. You know, that known precursor to Cardiovascular Dz, Diabetes, & CKD. Thanks #LACARE! What am I paying you for? #LaCarewantsyousick

Millions of people with #MetabolicDisease #InsulinResistance are being helped by GLP-1’s where changes in diet/exercise/lifestyle (for years) have done nothing! Why are #insurance companies like #LACARE gatekeeping this treatment plan?

A comprehensive review of how lipid metabolism shapes osteoporosis, from clinical implications to cellular mechanisms.
#LipidMetabolism #Osteoporosis #BoneMetabolism #Adipogenesis #BoneHealth #MetabolicDisease
www.sciencedirect.com/science/arti...

Redirecting

Can #BrownAdipose tissue be activated for therapeutic benefit in #MetabolicDisease? Possibly by harnessing cell-autonomous pathways: doi.org/10.1016/j.mo... @BaurLab #TranslationalScience

"People with mental illness are dying 15 years earlier."
"The primary cause of death in the mentally ill is cardiovascular disease. It's just happening 15yrs earlier." #MetabolicDisease #MetabolicPsychiatry #SavingLives
www.youtube.com/watch?v=d1az...

Rare Metabolic Diseases: Advancing Understanding, Improving Outcomes This episode of the https://www.spreaker.com/show/progress-educational-trust-podcast discusses how to improve diagnosis, treatment and support for people affected by rare and inherited metabolic diseases. The discussion is chaired by Sarah Norcross (Director of PET), with contributions from: ⚫ Jonathan Gibson (Lead for Campaigns and Communications at the charity Metabolic Support UK) ⚫ Dr Srividya Sreekantam (Consultant in Paediatric Metabolic Medicine at Birmingham Women's and Children's Hospital NHS Trust) ⚫ Professor Evangeline Wassmer (Consultant in Paediatric Neurology at Birmingham Women's and Children's Hospital NHS Trust) ⚫ Professor Frances Platt (Professor of Biochemistry and Pharmacology at the University of Oxford) ⚫ Dr Julien Baruteau (Consultant in Paediatric Metabolic Medicine at Great Ormond Street Hospital for Children) All of us who live, breathe, eat and think are able to do so thanks to our metabolism – the set of chemical reactions via which substances are transformed inside our bodies, in order to sustain the functioning of our cells, tissues, organs and systems. Our metabolism enables us to obtain usable energy from the food that we consume, and then get rid of toxins that are left over. All of this is in turn dependent on our DNA, which tells our body how to manufacture certain molecules that make metabolism possible. A vast range of diseases can disrupt human metabolism, and thousands of these diseases can be inherited. Such inherited metabolic diseases are rare, in the sense that the precise cause and consequence of each disease occurs in a relatively small number of people. Collectively, however, inherited metabolic diseases are common. Many inherited metabolic diseases affect the central nervous system, but such diseases can potentially affect any of our bodily systems. The impact of such diseases – on children, adults and families – can be devastating. In this podcast, experts and advocates – including the pioneers of relevant medications, and of a gene therapy that involves genome editing – discuss how best to address challenges posed by rare and inherited metabolic diseases. Aspects discussed include diagnosis, treatment, support and broader public understanding. PET is grateful to Amicus Therapeutics for supporting this discussion. PET is also grateful to Jon Nicoll, who created the opening and closing music for its podcast. Register at https://www.progress.org.uk/events/upcoming-events/ for upcoming PET events.

📣 New Podcast! "Rare Metabolic Diseases: Advancing Understanding, Improving Outcomes" on @Spreaker #metabolic #metabolicdisease #raredisease #rarediseases

Long-chain acyl-CoA synthetases: biological functions, diseases and therapeutic targets - Molecular Biomedicine The long-chain acyl-CoA synthetase (ACSL) family comprises key enzymes that are integral to the fatty acid metabolic pathway and play crucial roles in governing fatty acid (FA) metabolism and lipid ho...

#Review
Long-chain acyl-CoA synthetases: biological functions, diseases and therapeutic targets doi.org/10.1186/s435...

#Cancer #ACSLs #FattyAcid #metabolism #Ferroptosis #MetabolicDisease #Cardiovascular #Cerebrovascular

Homepage | NPKUA Hi, I’m Bella! Here’s How You’re Changing Lives Like Mine… Read More

Today is #NationalPKUAwarenessDay!🩵💙

Learn about #Phenylketonuria (PKU), a rare #metabolicdisease affecting 1 out of every 25,000 people living in the US, here:

We finish #MetabolicDisease- cilia on preadipocytes controlling 2 competing ciliary signaling cascades to differentiate or proliferate via FFAR4 or PGE2/EP4, via ROCK2 on actin stress fibers to grow lipid droplets. Wowed by @guacamarklee.bsky.social from the Hilgendorf lab! #UKCilia2025 /7

Metabolic dysfunction–associated kidney disease (MDAKD) links metabolic syndrome & CKD. Prevention must include early risk assessment, lifestyle change & novel therapies (SGLT2i, GLP-1RA).
👉 www.kidney-international.org/article/S008...

#KidneyHealth #CKD #MetabolicDisease

#HelmholtzDiabetes2025

Philipp Scherer Was Honored With the Helmholtz Diabetes Lecture Award👏

🎥 Watch the video and learn more about his research and thoughts on the conference!

@diabresearch-dzd.bsky.social

#DiabetesResearch #LiverHealth #MetabolicDisease

Documentary coming august 13:

Restoring Health, Reversing Diabetes: An American Diabetes Society Virtual Fundraiser

#diabetes2 #diabetes #metabolicdisease

www.youtube.com/watch?v=r-Ul...

Could adjusting your diet lower your cancer odds? Metabolic diseases such as hypertension or diabetes can elicit an inflammatory response that damages a person's DNA, which over time may cause normal cells to become cancerous.

"Our view of #cancer as a #genetic #disease drove the development of therapies that target specific genetic mutations..but we now know that cancer is a #MetabolicDisease with unique #metabolic needs.": buff.ly/PaJDGji

via NationalGeographic .com

Perspectum partners with the London Institute for Healthcare Engineering The partnership builds on the company’s work that AI-powered MRI scans are cost-effective in clinical pathways and can replace liver biopsies in patients.

Perspectum has partnered with the London Institute for Healthcare Engineering to speed up the translation of imaging solutions for metabolic disease and cancer from research to patient care.

healthcaretoday.com/article/pers...

#healthcare #medicalimaging #metabolicdisease #cancer #patientcare

Congrats to our #PosterPrize winners at the #MetabolicMultiomics25 conference!

🥇 - Bethan Hawkins
🥈 - Prateek Sharma & Antigone Dimas

Incredible science from all three, thank you for sharing your work!

#Multiomics #MetabolicDisease #Genomics

EASD Graphic announcing a call for applications for the position of Editor-in-Chief for Metabologia, a new international open-access journal from EASD. The text explains the journal will publish research on diabetes, obesity, and metabolic diseases. EASD logo and website link featured on the bottom ribbon of the graphic.

📢 #Vacancy Alert! We’re seeking an #Editor-in-Chief for our new journal, Metabologia. The #journal will publish original research, reviews, commentaries & more, incl. negative findings.

📅Apply by 15 June 2025

More Info👉 diabetologia-journal.org/wp-content/u...

#diabetes #obesity #metabolicdisease

Global rates of overweight and obesity are rapidly increasing

🌟 Research mission at #HelmholtzMunich is to prevent, treat, and ultimately cure obesity and diabetes.

👉Take a look at our latest infographic & more:
t1p.de/lybgu

#MetabolicDisease #Diabetes #Overweight #healthcare

LAST CALL:

SIMD Travel Awards are due TOMORROW (4/30/25) for the ICIEM2025 meeting. Please visit this link to submit your abstract for review:

simd.planion.com/Z?795957474

#inheritedmetabolicdisorders #inbornerrorsofmetabolism #metabolicdisease

Check out #dkNET community news, events and #funding announcements in April 2025!
dknet.org/about/blog/2...
#endocrinology #diabetes #metabolicdisease #webinar #datascience

Don't forget to check out #dkNET community news, events and #funding announcements in March 2025!
dknet.org/about/blog/2...
#endocrinology #diabetes #metabolicdisease #webinar #datascience

Early-Life Gut Microbes May Protect Against Diabetes, Research in Mice Suggests | Newswise Gut microbes shape pancreas development in infancy, leading to long-term changes in diabetes risk, new research in mice has found. The results could ultimately help doctors reduce the risk of type 1 d...

Early-Life Gut Microbes May Protect Against Diabetes, Research in Mice Suggests
www.newswise.com/articles/ear...
#diabetes #microbiome #GutMicrobiome #pancreas #MetabolicDisease #insulin

Metabolic.ie PDF of handy phrases in a few European languages for folks with PKU when we’re travelling out of the anglophone bubble. #PKU #MetabolicDisease #RareDisease #PhenylKetoneUrea
metabolic.ie/wp-content/u...