IFNγ-induced memory in human #macrophages is sustained by the durability of #cytokine signaling itself. From Aleksandr Gorin, Alexander Hoffmann and colleagues @ucla.edu: rupress.org/jem/article/...
📘 Part of JEM #Immunology collection 👉 rupress.org/jem/collecti...
#AAI2026
By mapping where these macrophages are and how they interact with the brain, she can identify new targets to improve the outcome of inflammatory diseases.
#immunology #singlecell #spatialbiology #research #macrophages
4/4
Left: Time-lapse images of cells subjected to (top) 0–10 nM C5a with cell tracks, (bottom) 0–10 nM C5a in the presence of 10 μM PMX-53 (inhibitor), Right: Spider plots for 0–10 nM C5a (top), and 0–10 nM C5a in the presence of 10 μM PMX-53 (bottom).
#Macrophages don't simply follow cues to locate sites of infection. @robinsall.bsky.social &co show that they extract directional information from their environment from a constant concentration of C5a #chemoattractant, self-generate a gradient & enhance guidance @plosbiology.org 🧪 plos.io/4txkZez
Clinical isolates of Prototheca wickerhamii reveal how this pathogen interacts with macrophages, providing insight into host immune responses and mechanisms of infection.
doi.org/10.1016/j.dc...
#ProtothecaWickerhamii #Macrophages #HostPathogenInteraction #ClinicalIsolates #InnateImmunity
Left: Time-lapse images of cells subjected to (top) 0–10 nM C5a with cell tracks, (bottom) 0–10 nM C5a in the presence of 10 μM PMX-53 (inhibitor), Right: Spider plots for 0–10 nM C5a (top), and 0–10 nM C5a in the presence of 10 μM PMX-53 (bottom).
#Macrophages don't simply follow cues to locate sites of infection. @robinsall.bsky.social &co show that they extract directional information from their environment from a constant concentration of C5a #chemoattractant, self-generate a gradient & enhance guidance @plosbiology.org 🧪 plos.io/4txkZez
Scientists show #CSF1R correlates with poor prognosis in #OvarianCancer, and blocking it with PLX3397 enhances #paclitaxel efficacy, reprograms #macrophages, boosts #AntitumorImmunity, and reduces #angiogenesis, highlighting it as a promising target.
Read: doi.org/10.1016/j.ge...
Left: Time-lapse images of cells subjected to (top) 0–10 nM C5a with cell tracks, (bottom) 0–10 nM C5a in the presence of 10 μM PMX-53 (inhibitor), Right: Spider plots for 0–10 nM C5a (top), and 0–10 nM C5a in the presence of 10 μM PMX-53 (bottom).
#Macrophages don't simply follow cues to locate sites of infection. @robinsall.bsky.social &co show that they extract directional information from their environment from a constant concentration of C5a #chemoattractant, self-generate a gradient & enhance guidance @plosbiology.org 🧪 plos.io/4txkZez
TREM2-mediated Macrophage Glycolysis Promotes Skin Wound Angiogenesis via the Akt/mTOR/HIF-1α Signaling Axis
This study finds that #TREM2⁺ #Macrophages drive # WoundRepair by linking #Glycolysis to #Angiogenesis via Akt/#mTOR/#HIF1α pathway, revealing #therapeutic targets for #TissueRegeneration. #medsky
Full article here: doi.org/10.1007/s115...
#WoundHealing #TherapeuticTargets #DrugDiscovery
The pieces go very well together and show the immunomodulatory capacity of adipose tissue for #immunotherapy (see
doi.org/10.1038/s413...) & also linking up with the brilliant work by @leilaakkari.bsky.social on #macrophages :
doi.org/10.1016/j.ce...
#science #immunology #cancer
Parse or 10x? any advice? we're thinking about trying Parse but would love some feedback from the #immunology community. this sequencing project is for lung #macrophages if that matters? please circulate and send me any info about your experiences!! @jeffmold.bsky.social have you used Parse?
CD9 as promising therapeutic target to modulate pathogenic #AdiposeTissue #Macrophages activity while preserving essential homeostatic functions insight.jci.org/articles/vie... @drdavidhill.bsky.social #Obesity #MetabolicDisease #TranslationalScience
Here here for retiring an often overgeneralized M1-M2 binary phenotypic framework. #macrophages express an incredible large array of sensome receptors that allow them to tailor their phenotype and reactions to the needs of incredibly local environments. #neuroskyence #immunosky #glia
Awesome discussion for those of us who love resident #macrophages in all their forms, and wonder what allows some to be be self renewing
#neuroskyence #immunosky #glia #neuroinflammation
Resident tissue #macrophages (RTM) are now recognized as integral regulators of tissue physiology, not transient immune sentinels. one fundamental question remains unresolved: why do some populations achieve lifelong self-maintenance, while others are replaced under steady-state conditions? 🧵1/11
#Macrophages are essential for this process but how they are instructed inside the injured heart remaines unclear. We wanted to understand the local signals that push them towards regeneration. So we combined #singlecell RNA-seq with #spatial #transcriptomics to map the regenerating hearts.
Excited to share our #preprint showing that #macrophages in the regenerating #zebrafish #heart are shaped by local cardiac-immune microniches, with a fibroblast-to-macrophage signal promoting regeneration over fibrotic repair www.biorxiv.org/content/10.6...
@idrm.ox.ac.uk @oxforddpag.bsky.social
Human CD4+ T cells recognize Mycobacterium #tuberculosis–infected #macrophages amid broader responses, from Stetsenko, Gail, Carpenter et al. rupress.org/jem/article/...
📘 Updates on the Immune Responses to #TB and #HIV: rupress.org/jem/collecti...
#KSTB26 #KSHIVVax26
Researchers @universitedeliege.bsky.social, an EARA member, have identified a new molecular switch that enables immune cells, called macrophages, to fully develop and protect organ health.
www.eara.eu/post/importa...
#immunity #AnimalResearch #mice #molecularBiology #macrophages #health #science
New study @jem.org from Chen et al. identifies #hypoxia-inducible protein 2 (HIG2) as a key regulator of anti-inflammatory property of Ly6ChighLy6Glow monocyte-derived #macrophages in the ischemic brain after #stroke through mediating phosphatidylcholine synthesis. rupress.org/jem/article/...
New study from Chen, Wang, Huang et al. identifies #hypoxia-inducible protein 2 (HIG2) as a key regulator of anti-inflammatory property of Ly6ChighLy6Glow monocyte-derived #macrophages in the ischemic brain after #stroke through mediating phosphatidylcholine synthesis. rupress.org/jem/article/...
Je suis ravie de parler de mes cellules préférées, les #macrophages, lors des 28 ème journées francophones de Virologie. Souvent la cible des virus, de façon direct ou indirect, les macrophages peuvent parfois voir leurs fonctions détournées.
RDV en avril pour en savoir plus !
Abel Ang, Albena Dinkova-Kostova, John Hayes and colleagues @dundee.ac.uk report that "The CNC-bZIP transcription factor #Nrf2 controls expression of matrix metalloproteases in murine #Macrophages"
How #bacteria suppress immune defenses in stubborn #wound #infections ...
| #Enterococcus | #polymicrobial | #macrophages | #MicroSky | Via @sciencex.bsky.social
Don’t miss the seminar by @jaumouillelab.bsky.social next Wednesday March 18 at noon time in Paris @institutcochin.bsky.social on “eliminating cancer cells, a physical challenge for macrophages”! a zoom link will be provided later #cancer #macrophages #immunity
I'm looking forward to the next projects ahead! #macrophages rock!
@meduniwien.ac.at @cemm.oeaw.ac.at @bocklab.bsky.social
Finally, a big thank you to my family- without their support many things would not be possible!
Schematic overview of the findings of the publication by Suarez-Csrmona et al.
New publication on the role of #macrophages in shaping the tumor #microenvironment in #cancer ... leading to the exploration of #adipose tissue and it's impact on #innateimmunity and #adaptiveimmunity in #ovariancancer to the point where resistancr to […]
[Original post on mstdn.science]
This study identifies SPP1+ #macrophages as regulators of #DiscDegeneration, expanding in diseased discs, driving matrix loss via #SPP1, while #exosome-directed #SPP1 blockade restores autophagy and offers a promising therapeutic path.
#OpenAccess: doi.org/10.1016/j.ge...
🔔 Issue 5 of 2026 is live! Featuring:
🩸 In a Nutshell: Cutaneous wound #healing
🐠 Perspective: Advancing fish #immunotoxicology in a complex world
🪱 Review: Parasite-mediated disruption of brain vessels
📡 Plus original research: #macrophages and mechanisms of immune evasion
▶️ tinyurl.com/ymy5e7ky
IL-21 is not exclusively being sense by T or B cells! We could observe that lung #Macrophages, resident #NK cells and lung residents B cells were impaired in Hif1aiKO mice, and rescued by IL-21 (8/10).
Would a patient's #breastCancer develop #resistance to #therapy? X. Zhang, L Yu et al found a way to predict it. @jci.org @bcmhouston.bsky.social #macrophages #neutrophil blogs.bcm.edu/2026/03/03/f...
