Left: Time-lapse images of cells subjected to (top) 0–10 nM C5a with cell tracks, (bottom) 0–10 nM C5a in the presence of 10 μM PMX-53 (inhibitor), Right: Spider plots for 0–10 nM C5a (top), and 0–10 nM C5a in the presence of 10 μM PMX-53 (bottom).

#Macrophages don't simply follow cues to locate sites of infection. @robinsall.bsky.social &co show that they extract directional information from their environment from a constant concentration of C5a #chemoattractant, self-generate a gradient & enhance guidance @plosbiology.org 🧪 plos.io/4txkZez

Left: Time-lapse images of cells subjected to (top) 0–10 nM C5a with cell tracks, (bottom) 0–10 nM C5a in the presence of 10 μM PMX-53 (inhibitor), Right: Spider plots for 0–10 nM C5a (top), and 0–10 nM C5a in the presence of 10 μM PMX-53 (bottom).

#Macrophages don't simply follow cues to locate sites of infection. @robinsall.bsky.social &co show that they extract directional information from their environment from a constant concentration of C5a #chemoattractant, self-generate a gradient & enhance guidance @plosbiology.org 🧪 plos.io/4txkZez

Left: Time-lapse images of cells subjected to (top) 0–10 nM C5a with cell tracks, (bottom) 0–10 nM C5a in the presence of 10 μM PMX-53 (inhibitor), Right: Spider plots for 0–10 nM C5a (top), and 0–10 nM C5a in the presence of 10 μM PMX-53 (bottom).

#Macrophages don't simply follow cues to locate sites of infection. @robinsall.bsky.social &co show that they extract directional information from their environment from a constant concentration of C5a #chemoattractant, self-generate a gradient & enhance guidance @plosbiology.org 🧪 plos.io/4txkZez