TREM2-mediated Macrophage Glycolysis Promotes Skin Wound Angiogenesis via the Akt/mTOR/HIF-1α Signaling Axis

This study finds that #TREM2⁺ #Macrophages drive # WoundRepair by linking #Glycolysis to #Angiogenesis via Akt/#mTOR/#HIF1α pathway, revealing #therapeutic targets for #TissueRegeneration. #medsky

Full article here: doi.org/10.1007/s115...
#WoundHealing #TherapeuticTargets #DrugDiscovery

Kaempferol Improved Rheumatoid Arthritis by Regulating the Immune Imbalance of Treg/Th17

This study shows Kae alleviates #Arthritis in mice by balancing #Treg/#Th17 via the #miR34a/#Foxp3 axis, highlighting #therapeutic potential for #RA and #Immune #Homeostasis. #medsky

Full article here: doi.org/10.1007/s115...

#TargetDiscovery #TherapeuticTargets #DrugDevelopment

Aging and cancer hallmarks as therapeutic targets
www.scienceopen.com/hosted-docum...
#Aging #CancerHallmarks #TherapeuticTargets #CancerBiology #PrecisionMedicine

This review elucidates the reciprocal regulation of #m6A modifications and #ncRNAs, highlighting their critical roles in RNA metabolism and their potential as #TherapeuticTargets in various human diseases.

#OpenAccess: doi.org/10.1016/j.ge...

An overview of the reciprocal feedback between #Mechanotransduction & #Epigenetic remodeling, illustrating how these loops govern cellular fate & disease progression, and their role as #Biomarkers & #TherapeuticTargets.

#OpenAccess: doi.org/10.1016/j.ge...

This review summarizes the significance of different small noncoding RNAs (#sncRNAs) in #CardiovascularDisease #Pathogenesis, detailing their regulatory roles and potential applications as #Biomarkers & #TherapeuticTargets.
#OpenAccess: doi.org/10.1016/j.ge...

Acute pancreatitis is driven by complex inflammatory and immune mechanisms, with emerging therapeutic approaches targeting disease initiation and progression.
doi.org/10.1038/s413...
#AcutePancreatitis #Inflammation #InnateImmunity #TherapeuticTargets

Using a #Multiomics approach, this review defines novel #PDAC molecular subtypes to overcome #TumorHeterogeneity, providing a robust framework for identification of novel #TherapeuticTargets and #PersonalizedTreatment.

#OpenAccess: doi.org/10.1016/j.ge...

A New Class of Therapeutic Targets Identified for Aggressive Leukemias
Read: medicalxpress.com/news/2026-02...
#Leukemia #Oncology #Hematology #Research #Biopharma #TherapeuticTargets #Innovation #PrecisionMedicine #CancerResearch #LifeSciences

This review delineates the multifaceted roles of R-loops, detailing their physiological and pathological functions, characterizing them as key genomic regulators and potential #TherapeuticTargets in various diseases. #Cancer

#OpenAccess: doi.org/10.1016/j.ge...

⭐ Explore the NARCAN 5th Anniversary Symposium Collection!
🔬 Featuring exciting work on Polθ, HR, PARP inhibitors, emerging targets, and more!
Read here: lnkd.in/ezznFh2f
#NARCancer #DNARepair #CancerResearch #TherapeuticTargets #GenomicInstability

An overview of circRNAs in HBV-induced #HCC, delineating their roles as critical regulators of oncogenic signaling & #ImmuneEvasion while evaluating their potential as #Biomarkers and #TherapeuticTargets in #LiverCancer.

#OpenAccess: doi.org/10.1016/j.ge...

Targeting protein modifications in metabolic diseases
A broad review of protein modifications shaping metabolic disease progression, with implications for diabetes therapy.
doi.org/10.1038/s413...
#MetabolicDiseases #ProteinModifications #DiabetesResearch #TherapeuticTargets

Diabetic neuropathy: cutting-edge research and future directions
Advances in mechanisms, diagnostics, and emerging treatments for diabetic neuropathy and nerve damage.
doi.org/10.1038/s413...
#DiabeticNeuropathy #DiabetesComplications #Neurodegeneration #TherapeuticTargets

Crosstalk among Oxidative Stress, Autophagy, and Apoptosis in the Protective Effects of Ginsenoside Rb1 on Brain Microvascular Endothelial Cells: A Mixed Computational and Experimental Study

#Ginsenoside Rb1 protects BMECs from #Ischemia-reperfusion injury by regulating #Autophagy, #Apoptosis, and #OxidativeStress via SQSTM1/p62, ATG5, and HIF-1α, highlighting these as potential #TherapeuticTargets for #IschemicStroke.
Read: doi.org/10.1007/s115...

A comprehensive overview of #BileAcid (BA) metabolism alterations in #Sepsis, exploring the potential molecular mechanisms, while discussing the prospects & challenges of using BAs as diagnostic #Biomarkers & #TherapeuticTargets in sepsis.

#OpenAccess: doi.org/10.1016/j.ge...

HMGN2 regulates H3K27ac of the CDC20 promoter region, enhancing its transcription to drive #Glioma cell proliferation, thus positioning HMGN2/CDC20 axis as potential #Biomarkers & #TherapeuticTargets in glioma.

#OpenAccess: doi.org/10.1016/j.ge...

Integrated transcriptomics & bulk sequencing shows that SPP1+ macrophages drive #ColorectalCancer via pro-angiogenic & #Immunosuppressive pathways, highlighting them as potential #PrognosticBiomarkers & #TherapeuticTargets.

#OpenAccess: doi.org/10.1016/j.ge...

The mTOR pathway plays a central role in diabetic nephropathy progression—highlighting promising therapeutic targets.
#mTOR #DiabeticNephropathy #RenalDisease #TherapeuticTargets #Nephrology
www.sciencedirect.com/science/arti...

New insights connect ageing biology with pathways driving neurodegeneration, revealing targets for prevention and therapy.
#AntiAgeing #Neurodegeneration #CellularSenescence #TherapeuticTargets
www.nature.com/articles/s41...

This study reviews the classification && tissue-specific #Biogenesis of tsRNAs, elaborates describes their diverse molecular mechanisms & biological functions, while highlighting their potential as novel #Biomarkers & #TherapeuticTargets in #Cancer.

Read this #OpenAccess: doi.org/10.1016/j.ge...

Redox signaling governs stress responses, metabolism, and pathology. New frameworks highlight therapeutic targets across disease contexts.
#RedoxBiology #OxidativeStress #CellSignaling #TherapeuticTargets
www.nature.com/articles/s41...

This recent study identifies #PDK1 as a key regulator of #EGFR-#TKIresistance and points to emerging potential #Biomarkers and #TherapeuticTargets that could redefine strategies to overcome resistance in #LungCancer. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

This review summarizes LPA signaling, from #Biosynthesis and receptor pathways to #TherapeuticTargets, and presents an AI model that simulates network dynamics for predictive and #PersonalizedTreatment. #medsky @ou.edu

#STTT #OpenAccess: doi.org/10.1038/s413...

Highlighting the potential of natural compounds and their derivatives as less toxic, more effective preventive options for #Oncology by exploring their multilevel regulatory mechanisms, #TherapeuticTargets, and #DrugDelivery systems.

#STTT #OpenAccess: doi.org/10.1038/s413...

Can’t wait to meet you in Toronto🤩
This is our honor to have our keynote and invited speakers 🤩
@kislingerthomas.bsky.social and Dr. Isabelle Sirois
For more info about the program: cnpn.ca/cnpn2025/
#HUPO #proteomics #Neoantigens #biomarkerdiscovery #therapeutictargets #Pediatriccancerimmunotherapy

An overview of the #Epidemiology & characteristics of #LiverDiseases, the mechanisms underlying their pathogenesis, with discussion on the current #Diagnostic & treatment modalities, and potential #TherapeuticTargets. @pku1898.bsky.social

#OpenAccess: doi.org/10.1038/s413...

This review summarizes recent advances in the #ImmunologicalSynapse, detailing its structure, #SignalingPathways and highlights how its dysregulation drives disease while revealing #TherapeuticTargets for immune modulation. #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

Count down for CNPN and HUPO 2025 starte!
This is our honor to have our keynote and invited speakers 🤩
@kislingerthomas.bsky.social and Dr. Stuart Cordwell
For more info about the program: cnpn.ca/cnpn2025/
#HUPO #proteomics #multi-omics #biomarkerdiscovery #therapeutictargets #bacterialphenotypes

Reviewing the origins, biology, & functions of tissue-resident immune cells, with insights into their physiological & #pathological roles and their potential as #TherapeuticTargets & #biomarkers. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...