Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity - Nature Immunology Here the authors show DNGR-1 expressed by cDC1s promotes CD8⁺ T cell priming to cytoskeletal neoantigens from dying tumor cells, thereby shaping cancer immune visibility and tumor evolution through im...

#WeekendRead! #DendriticCellPower! @reisesousalab.bsky.social @drjonlim.bsky.social &co show @natimmunol.nature.com that cDC1s exploit DNGR1 to crosspresent #tumor #neoantigens derived from F-actin binding proteins protecting against tumorigenesis but favoring cancer immunoediting!

🔥 #December 25 #Genes & #Immunity is out! @springernature.com
⏰ www.nature.com/gene/volumes...
🧐Read abt: #neoantigens #cancer #immunotherapy; #Immunology of #primates, #livercancer, #lung #injury, #pulmonary #fibrosis, #rheumatoid #arthritis, #macrophages; #trained #immunity, & much more!

📰New & Featured | A study in #Cell discovered that secretion of #melanosomes can be blocked to enhance tumor #immunity
🔹Presence of melanosomes➡️poor prognosis + reduced T cell cytotoxicity + less responsive to immunotherapy
🔹Melanosome carry #TAAs and #neoantigens
#Melanoma

Harnessing the immune system and developing targeted vaccines: overall strategies of leveraging the body’s natural defense mechanisms to enhance cancer treatment
#OpenAccess in #RegenerativeMedicineReports: doi.org/10.4103/REGE...
#Cancer #Immunotherapy #Neoantigens #PersonalizedVaccines #Vaccines

Can’t wait to meet you in Toronto🤩
This is our honor to have our keynote and invited speakers 🤩
@kislingerthomas.bsky.social and Dr. Isabelle Sirois
For more info about the program: cnpn.ca/cnpn2025/
#HUPO #proteomics #Neoantigens #biomarkerdiscovery #therapeutictargets #Pediatriccancerimmunotherapy

Explore #frameshift derived onco #neoantigens in a dedicated datascope of R2platform.
This is just one of the many avenues R2 has to offer for scientists.
R2: open online nocode data science platform for biomedical researchers (r2.amc.nl)

#oncology #immunology #immunotherapy #cancer

-Viral antigens & chronic inflammation: 🦠 fragments, including persistent spike proteins, are believed to act as " #neoantigens," triggering an ongoing, systemic inflammatory response in #Longcovid
- In LC, circulating neutrophils display a persistently activated phenotype

Akari Therapeutics advances research on novel PH1 payload for targeted cancer therapy - PharmaTimes Akari Therapeutics has reaffirmed its commitment to advancing research on PH1, a novel spliceosome modulator payload used in its antibody drug conjugates

#oncology #immunotherapy #AkariTherapeutics #novelPH1payload #targetedcancertherapy #PH1 #antibodydrugconjugates #ADCs #oncogenicmutations #DNAsplicing #neoantigens #missplicedproteins #effluxtransporters #oncogenicdrivers #PH1spliceosomemodulatorpayload
pharmatimes.com/news/akari-t...

Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading - Nature Biomedical Engineering Lipid particles loaded with RNA coding for tumour-unspecific antigens can enhance early responses of type-I interferons, mediating the success of immune checkpoint inhibitors as well as epitope…

"administration of lipid particles loaded with RNA coding for tumour-unspecific antigens"

So much for the painstaking search for tumor-specific #neoantigens. Turns out you can just throw in whatever, or even nothing at all, and it still somehow works.

buff.ly/Xb1PbZx

Isolation of mitochondrial mutation-specific T cell receptors Abstract. Neoantigen-specific T cells play a major role in cancer immunotherapy. Mutated proteins derived from non-synonymous mutations in tumor genomic DN

Can mutations in tumor mitochondrial DNA ( #mtDNA ) generate #neoantigens recognized by T-cells? New report describes mtDNA mutation-specific TCRs. Can mutant mtDNA could be tumor #immunotherapy targets?

academic.oup.com/jimmunol/adv...

Individualized mRNA cancer vaccines make strides - Nature Biotechnology The first cancer vaccines matched to a person’s unique tumor neoantigens are forging ahead, with expectations running high as the field awaits results from the first pivotal trial.

Individualized #cancer #vaccines targeting #neoantigens have shown promise in small-scale studies, but the field is waiting on data from Merck's & Moderna's phase 3 trial of the #mRNA vaccine Intismeran autogene in #melanoma. Just out in @natbiotech.nature.com

www.nature.com/articles/s41...

Join us as we explore the scientific breakthroughs accelerating translational medicine!

#TTT25 #TranslationalMedicine #Microbiome #Pathology #Pharmacology #Neoantigens #Immunotherapy #BoğaziçiCT3Symposium #CT3Innovation #CT3Translation

Featured today by @MSKLibrary: Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias dx.doi.org/10.1016/j.ce...

#Neoantigens #LeukemiaResearch #CancerImmunotherapy #TCellReceptors #PrecisionOncology #TumorImmunology #CancerGenomics #TargetedTherapies

New targets for the treatment of pancreatic cancer – BioNews Central A newly discovered class of peptides expressed in pancreatic cancer cells could provide promising targets for T-cell therapies and other approaches to combat pancreatic tumors. ...

A newly discovered class of peptides expressed in #PancreaticCancer cells could provide promising targets for #TCellTherapies and other approaches to combat #PancreaticTumors.
#TherapeuticTargets #TumorAntigens #Neoantigens #Immunotherapy

MSK physician-scientist Dr. Christopher Klebanoff talked about all things #neoantigens for the Novel Classes of Human Cancer Rejection Antigens session this morning at #AACR25.

Neoantigens drive adoptively transferred CD8 T cells to long-lived effectors mediated by lymph node trafficking Adoptive transfer of neoantigen-reactive T lymphocytes mediates potent responses against solid tumors in patients while often limiting toxicity to normal tissues; however, the mechanisms governing the...

Tomorrow, in #PreprintClubHub1 MD Anderson’s own Samuel Andrewes will present a #preprint about #neoantigens driving adoptively transferred CD8 T-cells to long-lived effectors via lymph node trafficking. 🚗 🧓 🚦

www.biorxiv.org/content/10.1...

This week I presented an my continuing work on characterizing the immunopeptidome of malignant peripheral nerve sheath tumors at the the UMN masonic cancer center symposium #neoantigens #immunology #massspec

Tumour-wide RNA splicing aberrations generate actionable public neoantigens | Nature T cell-based immunotherapies hold promise in treating cancer by leveraging the immune system’s recognition of cancer-specific antigens1. However, their efficacy is limited in tumours with few somatic mutations and substantial intratumoural heterogeneity2–4. Here we introduce a previously uncharacterized class of tumour-wide public neoantigens originating from RNA splicing aberrations in diverse cancer types. We identified T cell receptor clones capable of recognizing and targeting neoantigens derived from aberrant splicing in GNAS and RPL22. In cases with multi-site biopsies, we detected the tumour-wide expression of the GNAS neojunction in glioma, mesothelioma, prostate cancer and liver cancer. These neoantigens are endogenously generated and presented by tumour cells under physiologic conditions and are sufficient to trigger cancer cell eradication by neoantigen-specific CD8+ T cells. Moreover, our study highlights a role for dysregulated splicing factor expression in specific cancer

Tumor-wide RNA splicing errors create neoantigens across various cancers, boosting T-cell immunotherapies! Limited mutations, massive potential. #Neoantigens PMID:39972144, Nature 2025, @Nature https://doi.org/10.1038/s41586-024-08552-0 #Medsky #Pharmsky #RNA 🧪

The resulting #mRNA sequence is used to guide the formation of an amino-acid chain that makes up a protein. In a #tumour , splicing can go wrong. In those instances, the cells produce incorrect or unusual proteins. The proteins produce structures called #neoantigens,

I just hit a follow to this list. 🇳🇱 #dutch #netherlands #cancer #melanoma #phase1 #clinical #neoantigens #precision #personalized #care #oncology bsky.app/profile/nkin...

Neoantigen immunogenicity landscapes and evolution of tumor ecosystems during immunotherapy with nivolumab - Nature Medicine In this biomarker cohort analysis of CheckMate 153, analyses of genomic alterations and neoepitope immunogenicity in tumor tissue samples from patients with non-small cell lung cancer treated with…

Study on non-small cell lung cancer treated with nivolumab shows that #neoantigens evolve during therapy. 80 patients analyzed; early loss of mutations impacts response. #cancer #immunotherapy PMID:39349627, Nat Med 2024, @NatureMedicine

mRNA Cancer Vaccines Spark Renewed Hope as Clinical Trials Gain Momentum Phase 3 clinical studies in people with melanoma and a type of lung cancer are underway, with earlier stage clinical trials for other cancers in the works.

mRNA vaccines are made quickly after analysis for specific cancerous “fingerprints” or #neoantigens. Based on these #proteins, Scientists can build a custom #mRNA #cancer #vaccine to train an immune system to fight & prevent the cancer recurring. #BioNTech
singularityhub.com/2024/06/26/m...

🔬 Join our team in the fight against #cancer!
We're looking for a motivated individual to pioneer cellular #reprogramming technology for identifying potent #neoantigens, advancing the frontier of #immunotherapy. Find more information and apply here: