This review highlights #NLRP3 as a key driver of #DiabeticCardiomyopathy, integrating #MetabolicStress to fuel inflammation, #pyroptosis & #fibrosis, and proposes strategies to target NLRP3 to break the metabolism–inflammation cycle.

#OpenAccess: doi.org/10.1016/j.ge...

DMSO: The Forgotten Therapy for "Incurable" Diseases In today's episode we're exploring the remarkable potential of DMSO, a simple compound that has been quietly treating conditions mainstream medicine often labels "incurable". We dive into case studies where individuals regained sight, reversed debilitating fibrotic conditions like Dupuytren's disease, and found relief from severe autoimmune disorders. Despite decades of research showing its effectiveness in treating inflammation, protein misfolding, and structural tissue damage, this therapy remains largely overlooked. Join us as we uncover the hidden science behind DMSO and why it might be one of the most versatile tools in health. References: - https://vigilantfox.news/p/the-cheap-forgotten-therapy-quietly - https://www.midwesterndoctor.com/p/how-dmso-treats-incurable-autoimmune Support our work. Make a small donation. Support our work. Make a small donation. This removes any advertisements and help us continue bringing more interesting topics and confronting mainstream narrative on health. Click the Link to support us: https://www.spreaker.com/podcast/foodnourish-deep-dives--6602003/support

📣 New Podcast! "DMSO: The Forgotten Therapy for "Incurable" Diseases" on @Spreaker #alternative #autoimmune #blindness #collagen #dmso #fibrosis #healing #health #holistic #inflammation #medicine #protein #recovery #research #science #scleroderma #therapy #treatment #truth #wellness

We are interested in adding #postdocs. If you like a fabulous team, city and research environment and are interested in #cellularengineering / #sytheticbiology, #ILCfibroblast interactions or #skin #fibrosis, contact me with your CV & interest statement. www.buechlerlab.com

Great @imgprague seminar by our PhD student Srikant Ojha @sojha148 on hepatic stellate cell #mechanosignaling and its potential for new therapeutic approaches in liver #fibrosis. Lab of Integrative Biology @Gregor_lab is leveling up 🚀

Spironolactone and Fibrosis in Heart Failure Risk: Machine Learning Analysis of HOMAGE Trial Plasma Proteomics In HOMAGE, 276 plasma proteins were profiled using Olink panels. Machine learning algorithms identified galectin-9 (GAL9), thrombospondin-2 (THBS2), and NT-proBNP as predictors of changes in procolla....

#Article in @medcomm.bsky.social #MedComm
#Spironolactone and #Fibrosis in Heart Failure Risk: #MachineLearning Analysis of #HOMAGE Trial Plasma Proteomics doi.org/10.1002/mco2...

Researchers from CIMA Universidadde Navarra and IdiSNA, Spain

#biomarker #HeartFailure #MLA #PICP

Returning from a fantastic #FusionLung26. Special shout out 👏to Ana Pardo-Saganta Stijn De Langhe and Purushothama Rao Tata for organizing such a special meeting! Thanks for letting me contribute and discuss #lung #fibrosis and #environmental lung injury. Such a pleasure to meet old and new friends!

Inhibitory effects of 1−18 on FN levels in TGF-β1-stimulated LX-2 HSCs.

🧪 New anti-liver fibrosis leads from Euphorbia wallichii.

A CJNM study reports 12 diterpenoids (Euphorwallnoids A–L), including a rare 5/7/6/5 tetracyclic scaffold. Compound 1 suppresses fibronectin, α-SMA, and collagen I in LX-2 cells.

Full read: doi.org/10.1016/S187...

#Fibrosis #NatProd #CJNM

Maybe I can entice you to take a look at the fancy full spectrum flow cytometry figures? There is more where that came from! #endothelialcells #vascularbiology #liver #fibrosis

Psicoterapia en personas con #fibrosis quística (FQ)

✔️ La #psicoterapia podría ser útil para abordar la ansiedad, depresión, la adherencia al tratamiento y el afrontamiento del estrés, en personas con FQ.

#Preevid #fibrosisquística 

👉https://www.murciasalud.es/preevid/26769

🧪 Did you know that 1 in 5 people living with #T2D have a degree of #fibrosis?

Prof. Kenneth Cusi urges clinicians to screen for and prevent #MASLD from progressing to cirrhosis #ADAConsensusReport.

📺 Watch the latest #ExpertInsights episode now: easd-elearning.eu/episode/361/...

#Liverhealth

Immune profiling links #autoimmune #hepatitis to human #herpes virus 6 and relaxin receptor antigens. New study from Arielle Klepper, Joseph DeRisi @biohub.org, Michele May-Sien Tana and colleagues @ucsanfrancisco.bsky.social: rupress.org/jem/article/...

#Autoimmunity #Fibrosis

Enhancing KLF15 expression in cardiomyocytes via a dCas9VPR-mediated transcriptional activation system prevents pathological remodeling and #Fibrosis, thereby establishing it as a critical regulator and #TherapeuticTarget in #HeartFailure.

#STTT #OpenAccess: doi.org/10.1038/s413...

Longitudinal Changes in Fibrosis Markers: Monitoring Stiffness/Fibrosis Progression and Prognostic Outcomes in MASLD Fibrosis-4 Index (FIB-4) is a noninvasive tool for assessing liver fibrosis in metabolic dysfunction-associated steatotic liver disease (MASLD). Howev…

#FIB-4 is widely used for #fibrosis assessment. But what about its changes over time?📈

🌏 A large international study shows how dynamic #FIB-4 may predict fibrosis progression and clinical outcomes in #MASLD
💡 Interesting implications for clinical practice!

📖: www.sciencedirect.com/science/arti...

🩹🫘 Fibrosis in kidney disease = scarring.

Repeated injury → “repair patch” → scar tissue replaces healthy tissue.
Scar tissue can’t filter blood → higher CKD progression risk.

#CKD #Fibrosis #KidneyHealth #Biomarkers #PICKEDproject

Elevated S100A9 in #HFpEF hearts drives oxidative stress and mitochondrial dysfunction; its deficiency restores #SIRT3 signaling, improves diastolic function, and reduces #hypertrophy and #fibrosis, supporting S100A9 as a therapeutic target.

#OpenAccess: doi.org/10.1016/j.ge...

In @jem.org, Klepper et al. show that patients with #autoimmune #hepatitis have a unique autoantibody signature, incl. evidence for cross-reactivity with a common #herpesvirus & antibodies targeting the antifibrotic relaxin receptor with potential to promote #fibrosis rupress.org/jem/article/...

Klepper, Tana, DeRisi et al. show that patients with #autoimmune #hepatitis have a unique autoantibody signature, incl. evidence for cross-reactivity with a common #herpesvirus & antibodies targeting the antifibrotic relaxin receptor with potential to promote #fibrosis rupress.org/jem/article/...

WMSM26 Best Abstract: targeting vascular dysfunction and fibrosis in diabetes-induced female sexual dysfunction via allosteric modulation of TG2 (Elif Alan Albayrak, Denmark).
#WMSM26 #SexualMedicine #WomensHealth #Diabetes #TranslationalResearch #Fibrosis #VascularBiology

Applications are welcomed for research into #Asthma #COPD #Fibrosis #IPF #LungCancer #Mesothelioma #Bronchiectasis #LungInfection and more

Intercellular communication from myotubes to fibroblasts is differentially impacted by mineralocorticoid receptor signaling and muscular dystrophy - Cell Communication and Signaling Cell Communication and Signaling - Replacement of striated muscle with fibrosis leads to the symptoms and fatality in Duchenne muscular dystrophy (DMD). Transient local production of the...

Happy to share our recent publication on intercellular communication from the Rafael-Fortney lab. Check this one out!
#fibroblasts #myotubes #DMD #skeletalmuscle #fibrosis

link.springer.com/article/10.1...

🎓Boost Your Hands‑On Lab Skills: Practical training for IBD Researchers!

The FIBROTARGET Training Academy supports early‑career IBD researchers with hands‑on modules across key immunological techniques.

🎬 Module 1: In vitro fibrosis models ➡️ https://loom.ly/7tKSj4M

#IBDResearch #Fibrosis

#Women #Female #Health #BlackWomen #WoC
#Uterus #Fibrosis #Gynecology
Lived it REAL a surgery
not as many # as Nyong has/had

What helped was #BIRTHCONTROL ♀️
[small #Nexplanon upperarm inserts] lessening hormone inducing creation besides other things help lower severity like large amounts of VitD

Info about MASLD: Metabolic dysfunction-associated steatotic liver disease involves fat accumulation in the liver, which may cause liver inflammation. Obesity and type 2 diabetes are the main risk factors.

Metabolic dysfunction–associated steatotic liver disease (#MASLD) involves accumulation of fat in the liver and may progress to liver inflammation and scarring (#fibrosis).

Learn more in this JAMA Patient Page: ja.ma/4tTZrtD

Tet2 deficiency–induced expansion of monocyte-derived #macrophages promotes liver #fibrosis. From Jiuxing Feng, Baitong Wu, Yujiang Geno Shi and colleagues: rupress.org/jem/article/...

📘 In #Hematopoiesis and #Myeloid Cells collection: rupress.org/jem/collecti...

#KSMyeloid26 #KSHemato26

Fibrosis pattern on CT predicts CPFE progression rate, but not survival Although fibrosis patterns help clinicians anticipate CPFE trajectory, treatment decisions should focus on fibrosis extent.

The findings suggest that although fibrosis patterns help clinicians anticipate CPFE trajectory and monitor the progression of the disease, treatment decisions should focus on fibrosis extent #radiology #CPFE #CT #fibrosis

Integrated analysis of single-cell RNA-seq and ATAC-seq in lens epithelial cells: Unveiling the role of ATF6 as a key transcription factor

#SingleCellAnalysis reveals #ATF6 drives #EpithelialMesenchymalTransition in #LensEpithelialCells, promoting #fibrosis & #cataract progression; inhibiting ATF6 reduces #STAT3 activation, highlighting ATF6–TAK1 signaling as a therapeutic target.
#OpenAccess: doi.org/10.1016/j.ge...

Wounds on the face heal with less scarring than wounds elsewhere on the body. The Longaker lab at @stanfordsurgery.bsky.social developed a strategy to promote facial-like reduced fibrosis at scar-prone sites.

#WoundHealing #Fibrosis

📃 https://bit.ly/4qfAuWB
🎙️ https://bit.ly/4thHuVG

This review highlights #vitronectin as a multifunctional glycoprotein regulating #thrombosis, tissue repair, and cell survival while driving #tumor progression, #fibrosis, and systemic diseases, underscoring its promise as a therapeutic target.

Read: doi.org/10.1016/j.ge...

Single-Cell Omics Analysis Reveals Critical Cell Subtypes and their Functional Attributes in Myocardial Ischemia-Reperfusion Injury Announcing a new article publication for BIO Integration journal. Cardiac cell death and myocardial fibrosis after ischemia-reperfusion (I/R) injury are the primary causes of impaired cardiac function...

This study uses #SingleCellTranscriptomics to identify C0 Atcayos+ cardiomyocytes that interact with #fibroblasts via Bmp6 and Fgf1 signaling after #IschemiaReperfusion, uncovering pathways that could reduce #fibrosis and help preserve #cardiac function.

Read: bio-integration.org/single-cell-...

Cellular #senescence drives #aging and disease via glycolytic reprogramming sustained by PGAM1‑Chk1 interaction, HIF‑2α, and FoxM1; disrupting PGAM1‑Chk1 binding eliminates senescent cells, improves aging physiology, and reduces #fibrosis.

#OpenAccess #STTT: doi.org/10.1038/s413...