Lactic acid drives #NLRP3 #inflammasome activation and caspase-1–like cytokine cleavage via intracellular acidification

www.nature.com/articles/s41... #OpenAccess #immunology

As a medical school professor, I've spent decades teaching that obesity causes inflammation. But we never knew exactly ... www.utsouthwestern.edu/newsroom/articles/year-2...

#MetabolicHealth #Obesity #Inflammation #NLRP3 #HealthLongevitySecrets

Discovery of potent and selective inhibitors of human #NLRP3 with a novel mechanism of action, from Kevin Wilhelmsen, Rebecca Coll @colllab.bsky.social and colleagues rupress.org/jem/article/...

📘 In our #InnateImmunity collection: rupress.org/jem/collecti...

#KSInnateImmune26

This review highlights #NLRP3 as a key driver of #DiabeticCardiomyopathy, integrating #MetabolicStress to fuel inflammation, #pyroptosis & #fibrosis, and proposes strategies to target NLRP3 to break the metabolism–inflammation cycle.

#OpenAccess: doi.org/10.1016/j.ge...

Post-translational modifications of NLRP3: to prime or not to prime? The NLRP3 inflammasome plays a central role in host defense against microbial infections but also contributes to inflammatory diseases. Functioning of NLRP3 strictly relies on two signals: a ‘priming ...

'Over the past two decades, substantial progress has been made in understanding the regulation of #NLRP3. Priming, initially thought to be simply transcriptional, emerged as a complex interplay between different post-translational modificat'
O. Dufies & @lozanzi.bsky.social
#Immunology

This review highlights #mtDNA leakage as a driver of #CellularSenescence and the SASP, activating cGAS–STING, #TLR9, and #NLRP3, while exploring strategies to block release or downstream sensing to combat #AgingRelatedDiseases.

#OpenAccess: doi.org/10.1016/j.ge...

New mechanistic insights on an old but fundamental mystery in innate immunity: how the #NLRP3 #inflammasome senses efflux of intracellular potassium ions - check out our new #biorxiv #preprint👇here: www.biorxiv.org/content/10.6...

I am excited to share with you an amazing video on the NLRP3 inflammasome pathway generated by talented Ann Liu from the Janet Iwasa lab @jiwasa.bsky.social @ann-hl.bsky.social. It shows the real structures of the pathway from #NLRP3, #ASC, #caspase-1, #GSDMD, #IL-1b, to #NINJ1. Enjoy!

In Burns & Trauma, using mouse and human wound models combined with multi-omics and single-cell analyses, the team demonstrates that NLRP3-driven inflammation is essential in early repair but becomes detrimental if sustained.
#NLRP3 #Wound repair
Details: doi.org/10.1093/burn...

Neutrophils and the NLRP3 inflammasome: a tale of proteases, kinases, and inflammation Cell type–specific mechanisms modulate Nod-like receptor family pyrin domain containing 3 inflammasome activation in macrophages and neutrophils, shaping i

Interested in the #NLRP3 #inflammasome in #neutrophils? Check out our recent review on this topic...: doi.org/10.1093/jleu...

Neutrophils and the NLRP3 inflammasome: a tale of proteases, kinases, and inflammation Cell type–specific mechanisms modulate Nod-like receptor family pyrin domain containing 3 inflammasome activation in macrophages and neutrophils, shaping i

"#Neutrophils and the #NLRP3 #Inflammasome: a tale of #Proteases, #Kinases, and #Inflammation" - read the new Review by Vinicius Leal @uspoficial.bsky.social & Alexander Weber @unituebingen.bsky.social

Sevoflurane #postconditioning alleviates cognitive impairment after hemorrhagic shock by activating the SIRT1/HIF-1α/NLRP3 pathway. doi.org/10.4103/mgr.... #Sevoflurane #CognitiveImpairment #HemorrhagicShock #Neuroprotection #SIRT1 #HIF1α #NLRP3 #MedicalResearch #Anesthesia #MedSky #neuroskyence

Insilico Medicine Advances ISM5059 as a Novel NLRP3 Inhibitor for Systemic Inflammation Treatment Insilico Medicine has nominated ISM5059, a peripheral NLRP3 inhibitor, as a preclinical candidate for treating systemic inflammation, showcasing AI-driven drug discovery's potential.

Insilico Medicine Advances ISM5059 as a Novel NLRP3 Inhibitor for Systemic Inflammation Treatment #Hong_Kong #Insilico_Medicine #NLRP3 #ISM5059

#PulsedElectroMagneticFields inhibit #NLRP3 #inflammasome activation, reduce endothelial inflammation and #pyroptosis, restore mitochondrial function via TRPV4 regulation, and delay #atherosclerosis progression, unveiling a mechanobiological pathway.

#STTT: doi.org/10.1038/s413...

Integrated omics analysis identifies mechanical irritation as a driver of #OSCC progression via the HIF-1α/ASC/ #NLRP3 pathway

www.sciencedirect.com/science/arti... #OpenAccess #MedSky

Recombinant viruses encode inflammasome reporter caspase-1 CARD-EGFP and inhibitory AIM2 nanobodies, which block inflammasome assembly in macrophages, but not monocytes.

... and engineered reporter poxviruses to impair AIM2 inflammasomes in human primary cells with inhbitory nanobodies, revealing that primary macrophages and keratinocytes assemble #AIM2 inflammasomes, while monocytes assemble #NLRP3 inflammasomes.

Crosstalk between NLRP3 Signaling and Histone Deacetylases in Inflammasome-Driven Diseases The NLRP3 inflammasome is a validated therapeutic target in inflammatory, metabolic, and neurodegenerative diseases. Epigenetic regulators, particularly histone deacetylases (HDACs), have emerged as key modulators of inflammasome priming and activation. Recent advances in medicinal chemistry have provided new chemical modalities for the mechanistic interrogation and the potential therapeutic modulation of NLRP3 signaling. This Perspective dissects the mechanistic interface between HDAC-dependent epigenetic control and NLRP3 signaling and highlights emerging chemical tools, including isoform-selective inhibitors and targeted protein degraders. We discuss the challenges of isoform selectivity, species-specific differences, and the therapeutic potential of HDAC-based strategies to attenuate aberrant NLRP3 activity while minimizing off-target effects. Understanding this epigenetic-inflammasome crosstalk may provide a framework for translating epigenetic modulation into innovative treatments for inflammasome-driven diseases.

🚀 New Perspective in J Med Chem out now! #HDACs meet #NLRP3 #inflammasome 🔬 Many thanks for the great collaboration! #DrugDiscovery
pubs.acs.org/doi/10.1021/...

Ramalin Ameliorates Alzheimer's Disease Pathology by Targeting BACE1, HDAC6, and MAPK Pathways Ramalin alleviates Alzheimer's disease pathology by selectively inhibiting HDAC6, reducing BACE1 levels, and suppressing neuroinflammation through downregulation of the NLRP3 inflammasome and iNOS. I...

#Article in #MedComm

Ramalin Ameliorates #Alzheimer's Disease Pathology by Targeting #BACE1, #HDAC6, and #MAPK Pathways doi.org/10.1002/mco2...

#Ramalin restores synaptic function impaired by #Aβ toxicity and improves cognitive performance in #AD mouse models.

#NLRP3

Inflammasome Dynamics in Psoriasis: AIM2, NLRP3, and NLRP1 at the Interface of Inflammation and Immunity - Premier Science AIM2, Inflammasome, NLRP1, NLRP3, Psoriasis, Autoinflammatory disorder.

doi.org/10.70389/PJS...

#psoriasis #inflammasome #AIM2 #NLRP3 #NLRP1 #inflammation #immunity

Discovery of potent and selective inhibitors of human #NLRP3 with a novel mechanism of action, from Kevin Wilhelmsen, Rebecca Coll @colllab.bsky.social and colleagues 👉 rupress.org/jem/article/...

📘 Part of 2025: The Year in Experimental Medicine rupress.org/jem/collecti...

#Inflammasome

Nlrp3 Inflammasome: Significance and Potential Therapeutic Targets to Advance Solid Organ Transplantation Can inflammation harm transplants? Review finds NLRP3 inflammasome drives rejection. #OrganTransplantation #NLRP3

Can inflammation harm transplants? Review finds NLRP3 inflammasome drives rejection. #OrganTransplantation #NLRP3
www.rimpacts.com/rd/p?c=10084... 📄DOI: doi.org/10.1080/1472...

Genetic removal of Nlrp3 protects against age-related and R345W Efemp1-induced basal laminar deposit formation - PubMed Chronic, unresolved inflammation has long been speculated to serve as an initiating and propagating factor in numerous neurodegenerative diseases, including a leading cause of irreversible blindness…

New research shows that blocking NLRP3 inflammasome activation sharply reduces early AMD-like retinal damage, spotlighting a powerful new avenue for prevention. #AMD #Ophthalmology #NLRP3 #Inflammation #Retina #VisionScience #MedTwitter #SciComm buff.ly/1exc7JR

#Research

ML345 is a potent and selective NLRP3 inflammasome inhibitor with anti-inflammatory activity doi.org/10.1186/s435...

#ML345 #NLRP3 #inflammasome #inhibitor #NEK7 #InflammatoryDisease #Miscarriage

Genetic removal of Nlrp3 protects against age-related and R345W Efemp1-induced basal laminar deposit formation - Cell Death & Disease Cell Death & Disease - Genetic removal of Nlrp3 protects against age-related and R345W Efemp1-induced basal laminar deposit formation

Sharing our latest work on #AMD and how dampening #Nlrp3 #inflammasome signaling protects against #BLamD retinal pathology in multiple mouse models.

www.nature.com/articles/s41...

ML345 is a potent and selective NLRP3 inflammasome inhibitor with anti-inflammatory activity - Molecular Biomedicine Excessive activation of the NOD-like receptor pyrin domain–containing protein 3 (NLRP3) inflammasome plays a key role in the pathogenesis of various inflammatory diseases. Despite the development of s...

#Research
ML345 is a potent and selective NLRP3 inflammasome inhibitor with anti-inflammatory activity doi.org/10.1186/s435...

#ML345 #NLRP3 #inflammasome #inhibitor #NEK7 #InflammatoryDisease #Miscarriage

ScienceDirect.com | Science, health and medical journals, full text articles and books.

#ToPrimeOrNotToPrime, this is the question! Excited for our new review @cp-trendsimmuno.bsky.social with @oceanedufies.bsky.social in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! #InflammasomePower! #Free 👇👇👇

Discovery of potent and selective inhibitors of human #NLRP3 with a novel mechanism of action by Kevin Wilhelmsen, Rebecca Coll @colllab.bsky.social @wwiem-qub.bsky.social et al: rupress.org/jem/article/...

From our #InnateImmunity collection: rupress.org/jem/collecti...

🚀 From Bench to Paper | How bacterial toxins trigger inflammation
Multiple cholesterol-dependent cytolysins (#CDCs) enter the #TGN, remodeling it to activate #NLRP3. K⁺ efflux is required for #ASC but not NLRP3 recruitment. Desulfolysin isn’t internalized due to its C-terminal structure.

@colllab.bsky.social et al. show that both BAL-0028 & BAL-0598 inhibit select hyperactive #NLRP3 mutations associated with #autoinflammation more potently than MCC950. BAL-0028 & BAL-0598 represent a new modality for NLRP3 inhibition in inflammatory diseases rupress.org/jem/article/...
#Inflammasome

Circadian Control of Pulmonary Endothelial Signaling Occurs via the NADPH Oxidase 2-NLRP3 Pathway - Shaon Sengupta, Yool Lee, Jian Qin Tao, Isha Akolia, Natalia Louneva, Kaitlyn Forrest, Oindrila Paul... Circadian rhythms are endogenous oscillations that occur with a 24-h periodicity and support organismal homeostasis. While the role of the circadian clock in sy...

Elucidating the bidirectional relationship between #CircadianClock & #Inflammation involving specific #MolecularPathways such as NOX2 in #PulmonaryVasculature journals.sagepub.com/doi/10.1177/... @SenguptaShaon #NLRP3 #TranslationalScience