Ramalin Ameliorates Alzheimer's Disease Pathology by Targeting BACE1, HDAC6, and MAPK Pathways Ramalin alleviates Alzheimer's disease pathology by selectively inhibiting HDAC6, reducing BACE1 levels, and suppressing neuroinflammation through downregulation of the NLRP3 inflammasome and iNOS. I...

#Article in #MedComm

Ramalin Ameliorates #Alzheimer's Disease Pathology by Targeting #BACE1, #HDAC6, and #MAPK Pathways doi.org/10.1002/mco2...

#Ramalin restores synaptic function impaired by #Aβ toxicity and improves cognitive performance in #AD mouse models.

#NLRP3

Scientists at the University of Sunderland have created two experimental drugs that block the enzyme HDAC6, showing hope in stopping or reversing liver fibrosis, a condition that often develops without symptoms and currently has no cure.

#LiverFibrosis #MedicalResearch #HDAC6 #LiverHealth

New Paper Alert! See our joint SynBioC – VIB-CMB work on #HDAC6 ubiquitin-binding domain inhibitors published in Eur. J. Med. Chem. doi.org/10.1016/j.ej... @elsevierconnect.bsky.social, with @rjharding.bsky.social, KU Leuven, @csbugent.bsky.social, K. Van Hecke. @fbwugent.bsky.social