Media and Medicine MEDIA and MEDICINE: How to Tell Stories That Make a Difference is a certificate program for those interested in using storytelling to advance health. We welcome healthcare professionals, medical, nurs...

MEDIA and MEDICINE: How to Tell Stories That Make a Difference is a certificate program for those interested in using storytelling to advance health.
#HarvardMed
#scicomm
#medcomm
ghsm.hms.harvard.edu/education/me...

#Highlight in @medcomm.bsky.social #MedComm

#OTOF Gene Therapy: From Breakthroughs to Roadmaps doi.org/10.1002/mco2...

The highlighted article in #NatureMedicine : doi.org/10.1038/s415...

#ClinicalTrials #GeneTherapy

#Letter in @medcomm.bsky.social #MedComm
#Clinical, #Prognostic, and #Biological Features of High-Risk Cardiometabolic Phenotype: The #REMODEL Study doi.org/10.1002/mco2...

Researchers from Duke NUS Medical School

Real‐Time MRI With Deep Learning for Efficient Evaluation of Neuromuscular Breathing Impairment Breathing impairment is an important and common symptom in neuromuscular disorders. Reliable diagnostics are highly warranted. Real-time MRI and deep learning-based lung segmentation were used to ana...

#Article in @medcomm.bsky.social #MedComm
#Real_Time #MRI With Deep Learning for Efficient Evaluation of #Neuromuscular Breathing Impairment doi.org/10.1002/mco2...

Researchers from University MedicalCenter Gottingen

#BreathingPattern #LOPD #Diaphragm #RespiratoryMuscleWeakness

Spironolactone and Fibrosis in Heart Failure Risk: Machine Learning Analysis of HOMAGE Trial Plasma Proteomics In HOMAGE, 276 plasma proteins were profiled using Olink panels. Machine learning algorithms identified galectin-9 (GAL9), thrombospondin-2 (THBS2), and NT-proBNP as predictors of changes in procolla....

#Article in @medcomm.bsky.social #MedComm
#Spironolactone and #Fibrosis in Heart Failure Risk: #MachineLearning Analysis of #HOMAGE Trial Plasma Proteomics doi.org/10.1002/mco2...

Researchers from CIMA Universidadde Navarra and IdiSNA, Spain

#biomarker #HeartFailure #MLA #PICP

A Novel Peptide, HS1002, Enhances Antitumor Activity via Dual Targeting of the GnRH Receptor and Human Telomerase Reverse Transcriptase in Prostate Cancer Cells HS1002, a new peptide targeting GnRHR and hTERT, demonstrates significant Anticancer activity in prostate cancer cells. The mechanism of HS1002 can be attributed to the reduction of serum testosteron...

#Article in #MedComm

A Novel #Peptide, #HS1002, Enhances #Antitumor Activity via Dual Targeting of the #GnRH Receptor and Human #Telomerase Reverse Transcriptase in Prostate Cancer Cells doi.org/10.1002/mco2...

Research team from Sungkyunkwan University

#hTERT #ImmuneResponse #ProstateCancer

Something Went Wrong Anthropic joins OpenAI's push into health care with new Claude tools

Anthropic and OpenAI are pushing into healthcare. Google just pulled AI Overviews for some medical queries after accuracy concerns. The opportunity is real, but so is the risk.

www.nbcnews.com/tech/tech-ne...

#AIinHealthcare #Claude #MedComm

LungSurg: A Generative AI System for Segmentation and Phase Classification in Thoracoscopic Lobectomy The study introduces LungSurg, an AI system designed to assist in video-assisted thoracoscopic (VATS) lobectomy for lung cancer by accurately identifying anatomical structures and surgical phases. Th...

#Article in #MedComm
#LungSurg: A Generative #AI System for Segmentation and Phase #Classification in #ThoracoscopicLobectomy
doi.org/10.1002/mco2...

#DeepLearning #lobectomy #ThoracicSurgery #SurgicalEducation

The Gut Microbiota as a Mediator in the Relationship Between Dietary Patterns and Depression Healthy dietary patterns are associated with gut microbial genera linked to lower depressive symptoms. In 644 older adults from the PREDIMED-Plus cohort, 16S rRNA sequencing and dietary scoring revea....

#Article in #MedComm
Prof. Jordi Salas-Salvadó @JordiSalasSalva and his group revealed The #GutMicrobiota as a Mediator in the Relationship Between #Dietary Patterns and #Depression doi.org/10.1002/mco2...

#MediterraneanDiet #MicrobiomeMediation #MentalHealth #sequencing

Tumor Immunotherapy and Microbiome: From Bench‐to‐Bedside Applications The microbiome is related to the efficacy of immunotherapy and can be utilized to predict the efficacy and adverse reactions of immunotherapy. Microbiome-targeted intervention strategies can improve ....

#Review in #MedComm
Tumor Immunotherapy and Microbiome: From Bench-to-Bedside Applications doi.org/10.1002/mco2...

#Review #ICIs #Immunotherapy #microbiome #TumorMicroenvironment #TME #FMT

Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreti...

#Review in #MedComm
Peripheral Nerves in #Cancer: Regulatory Roles and #Therapeutic Strategies doi.org/10.1002/mco2...

The review provides comprehensive insight into the interaction between #nerves and cancer cells, paving way for neuron-signaling-based anticancer therapies.

Inhibition of FOS‐Like Antigen 1 Reduces Chemoresistance to Temozolomide Through Stemness Reprogramming via IL‐6/STAT3Tyr705 Pathway The role of FOSL1 in TMZ response to GBM. FOSL1 enhances TMZ resistance by promoting cell cycle progression, MGMT expression, and IL-6-pSTAT3Tyr705-stemness axis. VEM is a potential candidate drug fo...

#Article in #MedComm
Inhibition of FOS-Like Antigen 1 Reduces #Chemoresistance to #Temozolomide Through #Stemness Reprogramming via IL-6/STAT3Tyr705 #Pathway

doi.org/10.1002/mco2...

#FOSL1 #TMZ #Glioblastoma #IL_6 #STAT3

Noninvasive Early Detection and Recurrence Monitoring for Non‐Muscle‐Invasive Bladder Cancer via Urine Tumor DNA: A Prospective Clinical Study In NMIBC surveillance, positive postoperative utLIFE-UC results before initial follow-up cystoscopy were significantly associated with increased relapse risk. Longitudinal analysis showed that positi...

#Article in #MedComm
#Noninvasive Early Detection and Recurrence Monitoring for Non-Muscle-Invasive Bladder Cancer (#NMIBC) via Urine Tumor DNA: A #Prospective #Clinical Study doi.org/10.1002/mco2...

#EarlyDetection #UrineTumorDNA #RecurrenceMonitoring

Mitochondrial Intercellular Transfer via Platelets After Physical Training Exerts Neuro‐Glial Protection Against Cerebral Ischemia Treadmill training protects against white matter injury and reduces cerebral infarction. Muscle-derived mitochondrial transfer via platelets is promoted by treadmill training. Platelet transfusion em...

#Article in #MedComm
#Mitochondrial Intercellular Transfer via #Platelets After Physical Training Exerts Neuro-Glial Protection Against Cerebral Ischemia doi.org/10.1002/mco2...

Studied by a team from Juntendo University
#CerebralInfarction #PlateletTherapy #stroke

#Article in #MedComm
Low Dose of #IL_2 Application for Graft-Versus-Host Disease (#GVHD) Prophylaxis Following Haploidentical Stem Cell Transplantation doi.org/10.1002/mco2...

#Tregs #interleukin_2 #NKcell

Regulation and Mechanism of Deleted in Breast Cancer‐1 on Dendritic Cell Function in Systemic Lupus Erythematosus LPS-stimulated DC activation upregulated DBC1. DBC1-deficient DC ameliorated murine SLE symptoms. DBC1 deficiency suppressed immune responses in DC. DBC1 deficiency lowered STAT5 expression and subse...

#Article in #MedComm
Regulation and Mechanism of Deleted in Breast Cancer-1 (#DBC1) on Dendritic Cell Function in Systemic Lupus Erythematosus (#SLE)
doi.org/10.1002/mco2...

#AutoimmuneDisease #DendriticCell #STAT5 #Tfh

#Review in #MedComm
#Wnt Signaling #Pathway: Biological Function, Diseases, and #Therapeutic Interventions doi.org/10.1002/mco2...

The review outlines its components, functions, regulators, and preclinical models, highlighting #SFRPs as context-dependent, biphasic modulators.

N6‐Methyladenosine Modification of circIST1 Promotes Hypoxia‐Inducible Factor α–mediated Glycolysis and Progression in Hepatocellular Carcinoma We identified first time a critical m6A modification of circIST1 on miR-140-3p/miR-182-HIF1α regulatory network involved in the HCC progression and tumor glycolysis, gaining mechanistic insights into...

#Article in #MedComm
This article identified first time a critical #m6A modification of #circIST1 on miR-140-3p/miR-182-HIF1α regulatory network involved in the #HCC progression and #tumor #glycolysis. doi.org/10.1002/mco2...

Landscape of Somatic and Age‐Related Pathogenic Structural Variations in Hepatocellular Carcinoma Revealed by Long‐Read Sequencing This study leveraged long-read sequencing (LRS) to provide a comprehensive analysis of structural variations (SVs) in the human hepatocellular carcinoma (HCC) genome. Somatic SVs were found to be mor...

#Article in #MedComm
Landscape of #Somatic and #Age-Related Pathogenic Structural Variations in Hepatocellular Carcinoma (#HCC) Revealed by Long-Read #Sequencing doi.org/10.1002/mco2...

#HBV #HepatocellularCarcinoma #C1orf #DPRX

#Article in #MedComm
#Obestatin Treatment Counteracts #Muscle Wasting by Reactivation of #Autophagy in Duchenne Muscular Dystrophy (#DMD), studied by a research team from Complejo Hospitalario Universitario De Santiag
doi.org/10.1002/mco2...

#mTORC1 #AMPK #ULK1 #NEDD4 #VPS34

Emestrin‐Type Epidithiodiketopiperazines Inhibited Gasdermin D‐Mediated Pyroptosis via Caspase‐3/7 Activation This study demonstrates that emestrin-type ETPs suppress GSDMD-mediated pyroptosis through caspase-3/7 activation, thereby attenuating inflammatory responses and conferring protection against sepsis....

#Article in #MedComm
Emestrin-Type Epidithiodiketopiperazines (#ETPs) Inhibited Gasdermin D-Mediated #Pyroptosis via #Caspase-3/7 Activation doi.org/10.1002/mco2...

#gasderminD #GSDMD #sepsis

#Article in #MedComm
Characterization of #Korean Colorectal Cancer (#CRC) Reveals Novel Driver Gene and Clinically #Relevant #Mutations
doi.org/10.1002/mco2...

#ColorectalCancer #microsatellite #instability #mutational #hotspot #tumor #mutational #sequencing

CCR2 Orchestrates Preferential Homing and Therapeutic Efficacy of Gingival Mesenchymal Stem Cell‐Derived Extracellular Vesicles in Rheumatoid Arthritis CCR2 orchestrates preferential homing of GMSC-derived extracellularvesicles to inflamed joints in rheumatoid arthritis.

#Article in #MedComm
#CCR2 Orchestrates Preferential #Homing and Therapeutic Efficacy of Gingival Mesenchymal Stem Cell-Derived Extracellular #Vesicles in Rheumatoid Arthritis doi.org/10.1002/mco2...

#chemotaxis #RheumatoidArthritis #RA #GMSCs #inflammation

#Review in #MedComm
#Organoids in #Cancer Research and #Regenerative Medicine: Current Status, Challenges, and Future Prospects doi.org/10.1002/mco2...

#DiseaseModeling #DrugScreening

#Review in #MedComm
Mastering #Organoid Growth: A Complete #Guide to Overcoming Methodological Challenges doi.org/10.1002/mco2...

#cholangiocyte #methodology #organoid #Applications

#Article in #MedComm
Longitudinal Analysis of Male Fertility Using an Acr-Luc Knock-In Mouse Model: A Preclinical Platform for Reproductive Toxicity Testing doi.org/10.1002/mco2...

#BioluminescenceImaging #MaleFertility #RReproductiveToxicity #Spermatogenesis

#Review in #MedComm
#Melanoma: Pathogenesis and Targeted Therapy doi.org/10.1002/mco2...

This review summarizes the molecular classification of melanoma, synthesizes current therapeutic approaches, and highlights persistent clinical challenges.
#NRAS #BRAF #immunotherapy

Sepsis Endotypes Defined by Lymphocyte Thresholds and Inflammation Inform Precision Immunomodulation Sepsis outcomes are shaped by immune–inflammatory imbalance. Integrative profiling identified critical lymphocyte thresholds and defined endotypes linking immune depletion with inflammation. Patients...

#Article in #MedComm
Sepsis Endotypes Defined by #Lymphocyte Thresholds and #Inflammation Inform #Precision Immunomodulation doi.org/10.1002/mco2...

Patients with low inflammation but lymphocyte loss benefited from corticosteroids, while hyperinflammatory endotypes did not.

Spatial Transcriptional Heterogeneity in the Infarct Core and Its Surrounding Regions Targeting Piezo1 Signals in Rats With Myocardial Ischemia‐Reperfusion Injury We employed spatially resolved transcriptomics to visualize and molecularly characterize the spatial distribution of gene expression profiles in the rats’ left ventricles following MIR injury. Furthe...

#Article in #MedComm
#Spatial Transcriptional #Heterogeneity in the Infarct Core and Its Surrounding Regions Targeting Piezo1 Signals in Rats With Myocardial Ischemia-Reperfusion Injury doi.org/10.1002/mco2...

#MIR #Piezo1 #SingleCell #RNA #sequencing

Monkeypox Virus: Epidemiology, Virology, Diagnosis, Vaccine, and Therapeutics This review provides a comprehensive overview of the latest research advances in MPXV, with a focused analysis across five core dimensions: epidemiology, virology, diagnosis, vaccine, and therapeutic...

#Review in #MedComm
#Monkeypox #Virus: Epidemiology, Virology, Diagnosis, Vaccine, and Therapeutics doi.org/10.1002/mco2...

#diagnosis #epidemiology #therapeutics #virology #vaccine