Inhibition of FOS‐Like Antigen 1 Reduces Chemoresistance to Temozolomide Through Stemness Reprogramming via IL‐6/STAT3Tyr705 Pathway The role of FOSL1 in TMZ response to GBM. FOSL1 enhances TMZ resistance by promoting cell cycle progression, MGMT expression, and IL-6-pSTAT3Tyr705-stemness axis. VEM is a potential candidate drug fo...

#Article in #MedComm
Inhibition of FOS-Like Antigen 1 Reduces #Chemoresistance to #Temozolomide Through #Stemness Reprogramming via IL-6/STAT3Tyr705 #Pathway

doi.org/10.1002/mco2...

#FOSL1 #TMZ #Glioblastoma #IL_6 #STAT3

This latest study reveals that #CUDC907 & #temozolomide synergistically suppress GBM progression, with CUDC-907 reducing resistance by inhibiting #DNAdamage repair mechanisms, promising novel #therapeutic avenues for GBM. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Patient says 16‑year temozolomide treatment broke six‑month guidelines

Jonathan Jones received temozolomide for 16 years, exceeding the UK six‑month guideline, while UHCW spent over £3.6 million on the drug between 2009 and 2024. Read more: getnews.me/patient-says-16-year-tem... #temozolomide #braincancer

This study demonstrates the critical role of TGFR2 and miR-590-3p signaling in regulating #Temozolomide sensitivity in #glioblastoma (GBM) and reveals the anti-GBM potential of LiPBAE-based nanomiRs. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

Transcriptomic analysis identifies the neuropeptide cortistatin (CORT) as an inhibitor of temozolomide (TMZ) resistance by suppressing the NF-κB-MGMT signaling axis in human glioma

This study reveals that #cortistatin inhibits the activation of the NF-κB pathway in #glioma cells, thereby inhibiting MGMT expression, and interference with its expression could be a promising strategy for overcoming #Temozolomide resistance in glioma. #medsky

#OpenAccess: buff.ly/NTUa3XR

Selectively targeting BCL6 using a small-molecule inhibitor is a potential therapeutic strategy for glioblastoma

#BCL6 is a lynchpin in #GBM and YK01, a novel small-molecule inhibitor of BCL6, has an excellent anti-GBM bioactivity, promotes #apoptosis, inhibits growth of GBM cells, and in combination with #temozolomide suppresses the growth & #metastasis of tumors. #medksy

#OpenAccess: buff.ly/kjR2IlU

Targeting Wnt/β-catenin activation in combination with temozolomide leads to glioblastoma inhibition and long-term survival in mice

Co-treatment with Wnt-C59 and #Temozolomide inhibits Wnt signaling, reduces #Glioblastoma (GBM) cell proliferation & invasion, and inhibits the self-renewal properties of GBM #StemCells, thereby improving the overall survival of GBM-bearing mice. #medsky

www.sciencedirect.com/science/arti...

Promising survival outcomes in glioblastoma with autologous gamma-delta T cells - VJOncology Mina Lobbous, MD, MPH, Case Western Reserve University, Cleveland, OH, highlights promising results in overall survival (OS) rates and safety...

March is #BrainTumorAwarenessMonth in UK🧠

Exciting new data from Phase I study (NCT04165941) suggests that INB-200, a #gene-modified #autologous γδ T cell therapy, may offer improved overall survival rates for #glioblastomamultiforme patients receiving maintenance #temozolomide

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Therapy enhancing chromosome instability may be advantageous for IDH1R132H/WT gliomas Abstract. Recently revised brain tumor classification suggested a glioma treatment strategy that takes into consideration molecular variants in IDH1 and TP

🔬Genetic mutations in gliomas (IDH1R132H/TP53R248Q) increase chromosomal instability; cells with these are more sensitive to paclitaxel and temozolomide, suggesting new targeted therapies. Read more in NAR Cancer: doi.org/10.1093/narc...
#CancerResearch #Glioma #IDH1 #TP53 #Paclitaxel #Temozolomide

5 papers about Lung Cancer suggested by Stephen Liu - OncoDaily 5 papers about Lung Cancer suggested by Stephen Liu / atezolizumab, cancer, carboplatin, Catherine B. Meador, Daniele Tavernari, Eisaku Miyauchi, etoposide,

5 papers about Lung Cancer suggested by Stephen Liu
@stephenvliu.bsky.social

oncodaily.com/science/step...

#Atezolizumab #Cancer #Carboplatin #Etoposide #Medicine #Health #LungCancer #LCSM #Nivolumab #NSCLC #Olaparib #OncoDaily #Oncology #SCLC #Temozolomide