MILI participant Abbi talks about Li Fraumeni Syndrome and joining the MILI trial:
www.instagram.com/p/DWULPq8gSM...
To learn about the MILI trial and LFS, visit mili.octru.ox.ac.uk
#TP53 #LiFraumeniSyndrome #LFS @oncology.ox.ac.uk @oxfordcancer.bsky.social
A MILI Milestone: 60 participants randomised! Thank you to our recruiting sites:
@ouhospitals.bsky.social @gstt-nhs.bsky.social @cuh.nhs.uk @nottmhospitals.bsky.social @nhsgrampian.bsky.social @nhslothian.bsky.social @uhsft.bsky.social Manchester Uni Hospitals & Uni Hospitals Leicester
#TP53 #LFS
From www.nhs.uk: Metformin is safe to take during pregnancy.
Is metformin safe to take during pregnancy?
www.nhs.uk/medicines/me...
To learn about the MILI trial and LFS, visit mili.octru.ox.ac.uk
#TP53 #LiFraumeniSyndrome #LFS @oncology.ox.ac.uk @oxfordcancer.bsky.social
What is metformin? Metformin is a medicine used by tens of millions of people worldwide, mainly for type 2 diabetes. Lab results suggest metformin could also make cancer less likely to occur in people with Li Fraumeni syndrome, although currently this is only a theory. The MILI clinical trial has been set up to test this.
Metformin is a drug used mainly to treat diabetes.
Research suggests it may reduce the risk of cancer developing in people with Li Fraumeni syndrome.
To learn about the MILI trial and LFS, visit mili.octru.ox.ac.uk
#TP53 #LiFraumeniSyndrome #LFS
@oncology.ox.ac.uk @oxfordcancer.bsky.social
People with Li Fraumeni syndrome (LFS) have mutations in a gene called TP53. Do you know the difference between P53 and TP53? We do use them interchangeably a lot. P53 refers to the protein that the gene TP53 makes.
#livinglfs #iamlivinglfs #p53 #tp53 #tp53gene #lfsawarenessmonth #lfsawarenessday
Knowledge is power! Share LFS Facts throughout the month of March. Learn exactly what this rare genetic disease is about!
We are Living LFS!
www.LFSawareness.com
#LFSawarenessmonth #lfsawareness #lifraumeni #lifraumenisyndrome #livinglfs #iamlivinglfs #tp53 #geneticmutation #rarediseases
#RNAprofiling adds clinical value in cancer therapy: ≥6 altered genes link to shorter survival, while #TP53 mutations correlate with #VEGFA overexpression, suggesting possible #bevacizumab sensitivity. @mdanderson.bsky.social
#OpenAccess in #STTT: doi.org/10.1038/s413...
Share if you love someone with LFS!
#lifraumeni #lifraumenisyndrome #livinglfs #iamlivinglfs #lifraumenisyndromeawareness #p53 #tp53 #tp53gene #cancergenetics #geneticcancer #geneticmutation #rarediseases #cancerfighter #rarediseaseday #lfsawareness #rarediseaseday2026
Control groups make medicine safer and smarter.
By using control groups, scientists aren’t just guessing—they’re making informed decisions based on real evidence.
tinyurl.com/2hju2yfv
#LFS #TP53 #LiFraumeniSyndrome @oncology.ox.ac.uk @oxfordcancer.bsky.social
🩸Facts about Multiple Myeloma:
Myeloma Biology and Microenvironment
#MultipleMyeloma #Hematology #NKcells #Cytogenetics #HEMEHUB #TP53 #NFkB #Hyperdiploidy #t1114 #del17p #HemOnc #MedEd
The Manchester University NHS Foundation trust has opened for the MILI trial.
To learn more, visit mili.octru.ox.ac.uk/mili-sites
#TP53 #LiFraumeniSyndrome #LFS #NHSManchester @oncology.ox.ac.uk @oxfordcancer.bsky.social
This #STTT study analyzes genomic signatures at first-line #Osimertinib failure, identifying MET amplification and #TP53 co-alterations while demonstrating high concordance between tissue and plasma NGS diagnostics.
#STTT #OpenAccess: doi.org/10.1038/s413...
The LFS UK 2025 conference took place last September, updating on studies from across the country, including MILI.
Visit LFS UK 2025 to see the various presentations and update on the MILI trial tinyurl.com/d2dfm36x
#TP53 #LiFraumeniSyndrome #LFS @oncology.ox.ac.uk @oxfordcancer.bsky.social
#lifraumeni #lifraumenisyndrome #livinglfs #iamlivinglfs #lifraumenisyndromeawareness #p53 #tp53 #tp53gene #cancergenetics #geneticcancer #geneticmutation #rarediseases #cancerfighter
Happy New Year from the MILI Trial team! Thank you to all our brilliant sites for their work to date. This year we’re going to open more sites and recruit even more participants. To learn more about the MILI trial, visit mili.octru.ox.ac.uk To learn more about Li Fraumeni Syndrome, visit tp53.co.uk/lfs-tp53
To learn more about the MILI trial visit mili.octru.ox.ac.uk
@OUHospitals.bsky.social @GSTTnhs.bsky.social @cuh.nhs.uk @nottmhospital.bsky.social @NHSGrampian.bsky.social @UHSFT.bsky.social @nhslothian.bsky.social
@oxfordcancer.bsky.social @oncology.ox.ac.uk
#TP53 #LiFraumeniSyndrome #LFS
@OUHospitals.bsky.social @GSTTnhs.bsky.social @cuh.nhs.uk l @nottmhospital.bsky.social @NHSGrampian.bsky.social @UHSFT.bsky.social @nhslothian.bsky.social & Leicester Uni Hospitals
#TP53 #LiFraumeniSyndrome #LFS George Pantziarka TP53 Trust @oxfordcancer.bsky.social @oncology.ox.ac.uk
Differences in #TP53 status fundamentally altered early cellular responses to decitabine in a model of #MyelodysplasticSyndrome (MDS), revealing molecular features that may contribute to resistance and identify actionable targets.
Read here: https://bit.ly/4s4iQHt
Thinking of all our friends who know cancering doesn't take a break for the holidays 💙💚


#lifraumeni #lifraumenisyndrome #livinglfs #iamlivinglfs #lifraumenisyndromeawareness #p53 #tp53 #tp53gene #cancergenetics #geneticcancer #geneticmutation #rarediseases #cancerfighter
[禍害世人] 捐精男子基因攜帶罕見突變 問題精子造成近200名兒童身患癌症
每當有男性強調「傳宗接代」的中國陋習對牠有多麼重要時，我都會好奇，牠到底對於讓那些靈魂違反神意而降生、受困在貧病交加的肉體與人生中，到底是出於對誰的恨意…牠自己那糟糕的父母嗎？
#產業廢棄物 #TP53
🚨 Reminder for trainees: The 20th International p53 Workshop is accepting abstracts!
📅 Deadline: Dec 31, 2025 (5 PM EDT)
📍 Toronto | Apr 27–May 1, 2026
🔗 Submit now: p53.mshri.on.ca
Don’t miss your chance to present at this global event!
#TP53 #CancerResearch
12 days till the holidays!
THESE are the 12 months of LFS! 💚🐘💙
#lifraumeni #lifraumenisyndrome #livinglfs #iamlivinglfs #lifraumenisyndromeawareness #p53 #tp53 #tp53gene #cancergenetics #geneticcancer #geneticmutation #rarediseases #cancerfighter
" ... in 2005, which was sold to women from at least a dozen countries over roughly 17 years. He is healthy, but some of his cells had a mutation in a gene called #TP53. Donor checks don’t often look 4 rare mutations." 2/2 #CanSky
They need to look for #TP53!
www.statnews.com/2025/12/10/2...
This is awful!
"A sperm donor who unknowingly carried a gene variant that can cause #cancers fathered nearly 200 children across Europe, some of whom have already died, per an investigatn by European news orgs. The man started donating sperm at Denmark’s European Sperm Bank ..." 1/2 #CanSky #TP53
¿Cómo pudo un donante tener 200 hijos con un gen letal?
#Salud #ReproducciónAsistida #TP53 #LiFraumeni #EuropeanSpermBank #Genética #Oncología #España #UE #Noticias #SeguridadPaciente #9dediciembre #felizmartes
donporque.com/donante-200-...
Sperm from donor with cancer-causing genewas used to conceive almost 200 children | #cancer #TP53 #LiFraumeniSyndrome
A MILI Milestone: 50 participants randomised onto the trial!
Thank you to all our recruiting sites for support of the trial: @ouhospitals.bsky.social @gstt-nhs.bsky.social
@cuh.nhs.uk @nottmhospitals.bsky.social
@nhsgrampian.bsky.social @uhsft.bsky.social & Uni Hospitals Leicester
#TP53 #LFS
A multicenter study evaluating the genomic profile signature (GPS) of #NSCLC patients at first-line #Osimertinib failure shows high concordance between tissue & plasma GPS, revealing #EGFR, #TP53, & #MET alterations.
#STTT #OpenAccess: doi.org/10.1038/s413...
Association of ZWINT Expression with Clinicopathologic Characteristics and Prognosis in Breast Cancer Patients
This study revealed consistently elevated ZWINT #mRNA and #ProteinExpression in #BreastCancer, with high ZWINT levels linked to #CDH1 and #TP53 #Mutations and correlated with poorer #SurvivalOutcomes. #medsky
To read: link.springer.com/article/10.1...
According to recent findings, erythroid-predominant #MyelodysplasticSyndromes #MDS, found to be characterized by frequent multi-hit #TP53 alterations and BCL-XL upregulation, is also associated with poor outcomes after #venetoclax-based therapy: https://ow.ly/HAMr50XwV6o
#HemeSky
10 Days of Thankful.
We are Thankful for the countless researchers past and present who strive to find answers, treatments and options for our rare families with Li-Fraumeni Syndrome.
#lifraumeni #lifraumenisyndrome #livinglfs #iamlivinglfs #p53 #tp53 #tp53gene #LLFS #cancerresearch
