Screenshot 7years ago February 16, 2019 First post: First part of the date was a success... Saw my first Monet and almost cried. Second post: This week has been rough... One of the roughest ever... But my amazing partner is making it better. He's amazing! BTW... The food here is fantastic!

7 years ago. On the 13th of February, doctors called and informed me they found cancer in my stomach. The following weekend, my wonderful partner took me out to dinner at a fancy restaurant and to the local art museum to see a Monet to cheer me up as much as possible.

#cancer #gastriccancer #CDH1

Association of ZWINT Expression with Clinicopathologic Characteristics and Prognosis in Breast Cancer Patients

This study revealed consistently elevated ZWINT #mRNA and #ProteinExpression in #BreastCancer, with high ZWINT levels linked to #CDH1 and #TP53 #Mutations and correlated with poorer #SurvivalOutcomes. #medsky

To read: link.springer.com/article/10.1...

The transcriptomic architecture of common cancers reflects synthetic lethal interactions - Nature Genetics Tumor cells upregulate compensatory buffering genes following tumor suppressor loss. These genes may represent new synthetic lethal partners that could be harnessed therapeutically.

Uncovering synthetic lethal vulnerabilities across cancers. Upregulation of #TWIST1/2, #VIM, and integrin components ( #ITGB5, #ITGAV, #FERMT2 ) constitutes a synthetic lethal buffering mechanism that preserves tumor fitness despite #CDH1 #Ecadherin loss #lobular #DGC
www.nature.com/articles/s41...

Regulation of metastatic organotropism Metastasis is responsible for most cancer-related deaths. Different cancers have their own preferential sites of metastases, a phenomenon termed metastatic organotropism. The mechanisms underlying org...

Super nice review on metastasis organo-tropism⬇️ the process where tumor cells preferentially spread to specific distant organs, and represents a critical aspect of cancer biology with profound implications for patient outcomes. #CDH1
www.cell.com/trends/cance...

Wonderful presentations from a truly inspiring #Lobular Breast Cancer Symposium 2024 in Leuven!
Happy viewing! #CDH1 #ILC #TME #ImmunoILC #LOXL1 @elbcc-2018.bsky.social
www.youtube.com/watch?v=g7IN...
www.youtube.com/watch?v=g7IN...
www.youtube.com/watch?v=P56x...
www.youtube.com/watch?v=rOLa...

A Comprehensive Overview of Lobular Breast Cancer from the leaders of the new Memorial Sloan Kettering lobular breast cancer program #lobular #breastcancer #lobularbreastcancer #ILC #BREASTCANCER #CDH1
www.youtube.com/watch?v=gtZt...

Stomach cancer, the 5th most common cancer and the need for funding and education. Ever year we have to go to DC to advocate for funding. #FTS #CDH1 #nostomachgivesmemoreguts #warrior #badassidude #HDGC #nostomachforcancer #stomachcancer #lobularbreastcancer #debbiesdreamfoundation

Different #breastcancer genes🧬lead to different levels of #risk:
High risk genes (more than 4-fold risk) include #BRCA1, #BRCA2, #PALB2, #TP53, #PTEN, #CDH1
Less high risk genes (2-4 fold risk) include #CHEK2, #ATM, #BARD1, #RAD51C, #RAD51D

#InheritedCancer #Genetics #Education @tpalmd.bsky.social

Familieleden vinden van mensen met erfelijke aanleg voor borst- en eierstokkanker geeft hen de kans om
#kanker te voorkomen, kanker vroeg op te sporen en dit risico op kanker desgewenst niet over te dragen op de kinderen. #BRCA #PALB2 #CDH1 #PTEN /4

I’ve created a hereditary GI cancer starter pack #LynchSyndrome #Polyposis #CDH1

go.bsky.app/RLV4R1Q

CDH1 Mutation Distribution and Type Suggests Genetic Differences between the Etiology of Orofacial Clefting and Gastric Cancer Pathogenic variants in CDH1, encoding epithelial cadherin (E-cadherin), have been implicated in hereditary diffuse gastric cancer (HDGC), lobular breast cancer, and both syndromic and non-syndromic cleft lip/palate (CL/P). Despite the large number of CDH1 mutations described, the nature of the phenotypic consequence of such mutations is currently not able to be predicted, creating significant challenges for genetic counselling. This study collates the phenotype and molecular data for available CDH1 variants that have been classified, using the American College of Medical Genetics and Genomics criteria, as at least ‘likely pathogenic’, and correlates their molecular and structural characteristics to phenotype. We demonstrate that CDH1 variant type and location differ between HDGC and CL/P, and that there is clustering of CL/P variants within linker regions between the extracellular domains of the cadherin protein. While these differences do not provide for exact prediction of the phenotype for a given mutation, they may contribute to more accurate assessments of risk for HDGC or CL/P for individuals with specific CDH1 variants.

New #publication! We participated to an interesting study, published on @Genes_MDPI, to rationalize differences between #CDH1 #mutations causing gastric cancer and orofacial clefting https://www.mdpi.com/2073-4425/11/4/391