CSI Singapore Director, Prof. Ashok Venkitaraman reflects on discoveries in genome stability and the BRCA2 gene, and how translational platforms can move insights from lab to clinic.

Watch here: youtube.com/watch?v=KxWP...

#genomestability #BRCA2 #cancerresearch #oncologyresearch

The graph shows trends in mastectomy types and reconstruction, from 1994 to 2024. Mastectomy types include Nipple-sparing, Simple, and Skin-sparing. Reconstruction uses Implant/expander, Autologous tissue, or both. Data are shown in % of women.

A population-based study found that risk-reducing mastectomy in women with #BRCA1 or #BRCA2 pathogenic variants was associated with very low breast cancer risk and low rates of early major postoperative complications.

ja.ma/41fLVUm

Forest plots comparing RRBM vs control for breast cancer-specific mortality. A) Odds Ratio: studies Heemskerk-Gerritsen@19, Long@21, Marcinkute@22, Metcalfe@24, and Record@23. B) Hazard Ratio: studies Heemskerk-Gerritsen@19a and Metcalfe@24.

Risk-reducing bilateral mastectomy was associated with lower overall and breast cancer–specific mortality in female carriers of #BRCA1 and #BRCA2 pathogenic variants. ja.ma/4bljXLf

Father of 3 ‘Shocked’ by Rare Breast Cancer Diagnosis on 53rd Birthday, Says Regular Testing ‘Saved My Life’ (Exclusive) After discovering he carried the BRCA2 gene in 2013, one man began getting yearly mammograms. Twelve years later, he was still “shocked” to learn he had breast cancer and is now sharing his story to r...

In 2013, following a strong #familyhistory of #breastcancer, Jacob Johnson learned he was #BRCA2 +. Over a decade later, at the age of 53, the father of 3 was diagnosed with a rare & aggressive form of cancer in his right breast.

#bcsm #hereditarycancer #menshealth #genetics #patientexperience

BRCA2 is a key protein involved in repairing damaged DNA. Mutations in BRCA2 reduce DNA repair efficiency and increase the risk of cancers such as breast and ovarian cancer.
#CancerResearch #BRCA2

New in @nature.com!

Researchers led by Dr. Pedram Razavi of @mskcancercenter.bsky.social shows that tumors with germline #BRCA2 mutations are more likely to lose RB1 during CDK4/6 inhibitor treatment, leading to drug resistance and worse outcomes.

https://go.nature.com/4l8mZXQ

New from @nature.com: A team led by MSK breast medical oncologist Dr. Pedram Razavi found that tumors with germline #BRCA2 mutations or homologous recombination deficiency (HRD) are more likely to develop RB1 loss during treatment with CDK4/6 inhibitors, leading to therapeutic resistance.

Illustration of three pink ribbons with text: “Triple-negative breast cancer* can be a hereditary cancer red flag! * Breast cancer with no estrogen, progesterone, or HER2 receptors on the tumor. Learn more at www.genetionary.org.”

Inherited mutations in BARD1, BRCA1, BRCA2, PALB2, and RAD51D genes are linked to an increased risk for TNBC.

Learn more at www.genetionary.org
For more info please talk to your doctor and/or a certified genetic counselor.

#triplenegativebreastcancer #hereditarycancer #TNBC #genes #BRCA1 #BRCA2

Everybody has BRCA1 & BRCA2 tumor suppressor genes. BRCA genes produce proteins that help repair damaged DNA and prevent cancer. Inherited pathogenic mutations in these genes are linked to an increased risk of various types of cancer. Learn more at www.genetionary.org

Everybody has breast cancer suppressor genes.
Learn more at www.genetionary.org

#DNA #health #cancer #HereditaryCancer #genetics #geneticmutations #familyhealth #BRCA1 #BRCA2 #tumorsuppressorgenes

A new #Maturitas review examines #MaleBreastHealth 🔍 It highlights later diagnosis in men, the importance of identifying high-risk groups such as #BRCA2 carriers, and the role of imaging in assessment.
www.sciencedirect.com/science/article/abs/pii/...

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📝Online now - the Forum "DNA binding is a defining feature of BRCA2 orthologs" from Alice Chanteau, Fabien Nogue, and Rajeev Kumar.

#BRCA2 #DNAbinding #homologousrecombination #DNArepair

Read it here 👉 authors.elsevier.com/a/1mTkq3S6Gf...

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better-experience.blogspot.com/2026/01/the-...

#BRCA2
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Forest plots show pooled estimates of breast cancer-specific mortality with odds and hazard ratios. Studies are compared with RRBM vs. control, listing events, totals, and weights. Test results and heterogeneity are given.

Risk-reducing bilateral mastectomy was associated with lower overall and breast cancer–specific mortality in female carriers of #BRCA1 and #BRCA2 pathogenic variants. ja.ma/3N4fWmd

FDA Approves Niraparib Plus Abiraterone for BRCA2-Mutated Metastatic Castration-Sensitive Prostate Cancer - OncoDaily FDA approves niraparib plus abiraterone and prednisone for BRCA2-mutated metastatic castration-sensitive prostate cancer based on AMPLITUDE trial data.

FDA Approves Niraparib Plus Abiraterone for BRCA2-Mutated Metastatic Castration-Sensitive Prostate Cancer

@fda.gov

oncodaily.com/fda-approval...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #Niraparib #Abiraterone #BRCA2 #ProstateCancer #MCSPC

FDA Grants Approval for AKEEGA® Innovation in Treating BRCA2-Mutated Prostate Cancer Johnson & Johnson's AKEEGA® is now the first precision therapy approved for BRCA2-mutated metastatic castration-sensitive prostate cancer, showcasing significant treatment advantages.

FDA Grants Approval for AKEEGA® Innovation in Treating BRCA2-Mutated Prostate Cancer #USA #Horsham #Prostate_Cancer #BRCA2 #AKEEGA®

Using non-tumorigenic breast epithelial cells, we modeled two pathogenic BRCA2 variants:
✅ One caused reduced DNA repair & PARPi sensitivity (haploinsufficiency).
✅ The other produced a truncated BRCA2 protein that rewired gene expression & chromatin state.
#BRCA2 #CancerResearch

A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription - Nature Communications Pathogenic BRCA2 truncating variants in heterozygosis drive distinct cancer-linked mechanisms. Here the authors show that one causes PARPi sensitivity and HR loss via haploinsufficiency, while another...

🚨 Exciting news! Our latest study is out in Nature Communications!
We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair.
🔗 rdcu.be/eT1R9
#CancerResearch #BRCA2 #Genomics

The Role of Mediterranean Diet and Intermittent Fasting in Modulating Inflammation and Clinical Biochemistry Markers in Hereditary Cancer Syndromes: A Review - Current Nutrition Reports Current Nutrition Reports - This literature review of clinical and preclinical studies aimed to analyse the latest evidence on the Mediterranean diet (MD) and intermittent fasting (IF) to prevent...

New in @springer.springernature.com: "The existing literature clearly supports the protective role of MD and IF in limiting inflammation and possibly lowering the risk of cancer in patients with HCS such as BRCA1/2 mutations." #oncology #BRCA1 #BRCA2 #cansky #oncsky
link.springer.com/article/10.1...

ASSOCIATION BETWEEN TYPE AND LOCATION OF GERMLINE BRCA1/2 PATHOGENIC OR LIKELY PATHOGENIC VARIANTS WITH PHENOTYPE AND PROGNOSIS IN YOUNG PATIENTS WITH BREAST CANCER: RESULTS FROM AN INTERNATIONAL COHO... Clinical implications of specific pathogenic and likely pathogenic variant (LP/PV) types and locations in the BRCA1 or BRCA2 tumor-suppressor genes remain to be elucidated.

There are many different BRCA mutations – depending on the exon – which have different prognoses.

#breastcancer #oncology #cancer #genes #mutation #brca1 #brca2

www.annalsofoncology.org/article/S092...

Researchers resolve uncertainty in BRCA2 testing, improving cancer risk assessment and patient care - Mayo Clinic Comprehensive Cancer Center Blog Findings will help identify patients with breast, ovarian, pancreatic or prostate cancer who may benefit from targeted therapies.

Variants of uncertain significance are a pain. 🧩 Mayo Clinic researchers have made major strides recently classifying 91% of previously unknown #BRCA2 variants, bringing clarity to #hereditarycancer risk. A huge win for patients & #geneticcounselors.

Mary-Claire King and the secrets written in our DNA While pancreatic cancer is the eighth most commonly diagnosed cancer in Australia, it’s estimated that it will be the third most common cause of death from cancer in 2025.

November marks #PancreaticCancer Awareness Month with World Pancreatic Cancer Day today. The narrative doesn’t end with hereditary BC & OVCA. As research continued, another shadow emerged. #BRCA2 mutations particularly were found to ⬆️ the risk of PC, 1 of the most silent & devastating cancers.

#ThrowbackThursday to the #HumanGenomeProject in honor of #BreastCancerAwarenessMonth - "In Dec '95, the work of >40 researchers (including @sgrayg.bsky.social) ...discovered a 2nd #BreastCancer susceptibility gene: #BRCA2... revolutionizing cancer research" 🧬
dmpi.duke.edu/news/simon-g...

Researchers are learning that breast cancers diagnosed after childbirth can be more aggressive — especially in people with #BRCA1 or #BRCA2 mutations.

Sharing your reproductive history gives your care team critical context to better tailor your treatment plan. 🔗bit.ly/45jMZJB

#BreastCancer

What is cascade testing and how is it used to prevent hereditary cancer?

The infographic can be downloaded at: genetionary.org/resources/

#HereditaryCancerWeek #CascadeTesting #Previvor #CancerPrevention #Cancer #health #familyhealth #GeneticTesting #LynchSyndrome #BRCA2 #BRCA1 #CHEK2 #ATM #PALB2

Germline BRCA2 Mutation and Lynch Syndrome in a Patient With Multiple Primary Malignancies Introduction: Deficiency in BRCA genes leads to impediment in DNA repair and is associated with an increased lifetime risk of breast, ovarian, prostate, and pancreatic cancer and melanoma. Lynch synd...

Case Report: Germline #BRCA2 Mutation and #LynchSyndrome in a Male Patient With Multiple Primary Malignancies.

#prostatecancer #menshealth #pancreaticcancer #lungcancer #hereditarycancer #genetics #openaccess #medsky #cancerresearch

What are germline mutations and what role do they play in hereditary cancer?

The infographic can be downloaded at: genetionary.org/resources/

#HereditaryCancerWeek #GermlineMutations #Cancer #GeneticTesting #LynchSyndrome #BRCA2 #BRCA1 #CHEK2 #ATM #PALB2 #PTEN #MLH1 #MSH2 #MSH6 #TP53 #DNA

Previvor Day Poster graphic. Previvor Day is a celebration of the courage and strength of those at higher risk for cancer due to certain inherited genetic mutations. Being a previvor does not mean you will get cancer. Previvorship is about being informed, proactive, and monitored regularly to significantly reduce the risk. Knowledge is power. Learn more about hereditary cancer at www.genetionary.org

Previvor Day is still a few day away, but this is being released now to help raise awareness and understanding of previvorship ahead of the day.

This poster can be downloaded at: genetionary.org/poster/index...

#hereditarycancer, #hereditarycancerweek, #previvor, #brca1, #brca2, #lynchsyndrome

Will I be diagnosed with cancer? Uncertainty is part of healthcare. Embrace it | Opinion Facing healthcare’s uncertainty is better than avoiding it | Opinion

As a researcher at USF who studies healthcare communication & as a patient with an inherited mutation in the #BRCA2 gene which greatly ⬆️ my lifetime risks for #breastcancer, #ovariancancer and #pancreaticcancer — I’ve seen how uncertainty plays out in personal & life-altering decisions.

❔ Did you know? Germline variants in the #PALB2 gene significantly increase breast cancer risk - often nearly as much as variants in #BRCA1 and #BRCA2.

Explore the most comprehensive, curated PALB2 data available - completely free in Mastermind! mastermind.genomenon.com/users/sign_u...