No Survival Advantage for Risk-Reducing Mastectomy Over Surveillance in BRCA1/2 Carriers | Targeted Oncology - Immunotherapy, Biomarkers, and Cancer Pathways Study finds risk-reducing mastectomy in BRCA1/2 carriers significantly cuts cancer risk but offers no overall survival benefit over intensive surveillance.

UK Study finds risk-reducing mastectomy in #BRCA carriers significantly cuts #breastcancer risk but offers no overall survival benefit over intensive surveillance. @targetedonc.bsky.social

#hereditarycancer #bcsm #womenshealth #genetics #cancerresearch #medsky

Genetic variants involved in rapid immune response linked to earlier breast cancer onset in BRCA1 carriers Damaging variants in genes involved in a rapid immune response (innate immunity) are significantly linked to earlier breast cancer onset in carriers of the harmful BRCA1 genetic mutation, reveal preli...

Damaging missense variants in innate immunity genes are associated with earlier age of #breastcancer onset in #BRCA1 185delAG carriers.

#hereditarycancer #bcsm #cancerresearch #genetics #womenshealth

Via @medicalxpress.com

Association between type and location of germline BRCA1/2 pathogenic or likely pathogenic variants with phenotype and prognosis in young patients with breast cancer: results from an international coho... The clinical implications of specific pathogenic and likely pathogenic variant (LP/PV) types and locations in the BRCA1 or BRCA2 tumor-suppressor genes remain to be elucidated.

Association between type and location of germline #BRCA pathogenic or likely pathogenic variants with phenotype and prognosis in young patients with #breastcancer: Results from an international cohort study.

#bcsm #hereditarycancer #womenshealth #genetics #cancerresearch

Menopause, Menarche Impact Breast Cancer Risk in BRCA Carriers In a compelling advance for cancer genetics and epidemiology, a groundbreaking study has been published exploring the interplay between natural reproductive milestones and breast cancer risk among

Natural menopause, menarche and #breastcancer risk in #BRCA pathogenic variant carriers: A Mendelian randomization analysis by UK researchers.

#hereditarycancer #bcsm #medsky #womenshealth #genetics

Cover of the booklet Peas and Q’s. Text: “Hereditary Cancer Info. PEAS and Q's is a 20-page booklet that helps illustrate the terms related to genes, genetic mutations, & hereditary cancer in a simple question-and-answer format. Download a free PDF copy at www.genetionary.org.”

This resource was produced to try and help explain genetic mutations and cancer risk to those unfamiliar with the subject. Download a free PDF copy at www.genetionary.org.

#freebooklet #genetictesting #health #cancer #HereditaryCancer #genetics #geneticmutations #familyhealth

💙 Memories from our latest #CNAGSymposium!
🗣️ Dr. @conxi_lazaro (@idibell.bsky.social) presented two national initiatives tackling unsolved hereditary cancer: IMPaCT Genómica Cáncer & IMPaCT VUSCan

🧬CNAG contributed to her research through cutting-edge sequencing
#CancerGenomics #HereditaryCancer

Previvorship - Final report Final project report: Social media for carriers of hereditary cancer syndromes

Final project report: Social media for carriers of hereditary cancer syndromes. @stefaniavicari.bsky.social @leverhulme.ac.uk

www.previvorship.org/final-report

#BRCA #lynchsyndrome #socialmedia #research #hereditarycancer

Father of 3 ‘Shocked’ by Rare Breast Cancer Diagnosis on 53rd Birthday, Says Regular Testing ‘Saved My Life’ (Exclusive) After discovering he carried the BRCA2 gene in 2013, one man began getting yearly mammograms. Twelve years later, he was still “shocked” to learn he had breast cancer and is now sharing his story to r...

In 2013, following a strong #familyhistory of #breastcancer, Jacob Johnson learned he was #BRCA2 +. Over a decade later, at the age of 53, the father of 3 was diagnosed with a rare & aggressive form of cancer in his right breast.

#bcsm #hereditarycancer #menshealth #genetics #patientexperience

"Genealogy and hereditary cancer prevention share a common thread. What is it?" "hint" (with arrow pointing to an illustration of a strand of deoxyribonucleic acid.) "To learn more, go to www.genetionary.org."

Knowing and sharing your family history as well as your family health history can help prevent hereditary cancer.

To learn more and to download a free family health history pedigree, go to www.genetionary.org.

#genealogyday #genealogy #cancer #hereditarycancer #genes #familyhealth

Illustration of three pink ribbons with text: “Triple-negative breast cancer* can be a hereditary cancer red flag! * Breast cancer with no estrogen, progesterone, or HER2 receptors on the tumor. Learn more at www.genetionary.org.”

Inherited mutations in BARD1, BRCA1, BRCA2, PALB2, and RAD51D genes are linked to an increased risk for TNBC.

Learn more at www.genetionary.org
For more info please talk to your doctor and/or a certified genetic counselor.

#triplenegativebreastcancer #hereditarycancer #TNBC #genes #BRCA1 #BRCA2

Everybody has BRCA1 & BRCA2 tumor suppressor genes. BRCA genes produce proteins that help repair damaged DNA and prevent cancer. Inherited pathogenic mutations in these genes are linked to an increased risk of various types of cancer. Learn more at www.genetionary.org

Everybody has breast cancer suppressor genes.
Learn more at www.genetionary.org

#DNA #health #cancer #HereditaryCancer #genetics #geneticmutations #familyhealth #BRCA1 #BRCA2 #tumorsuppressorgenes

Black & BRCA

#BRCA #genetictesting #genechat #hereditarycancer

Risk-Reducing Mastectomy, Surveillance Lead to Similar Survival in BRCA Carriers 'Reassuring' data show more breast cancers with surveillance, but no difference in survival

Risk-Reducing Mastectomy, Surveillance Lead to Similar Survival in #BRCA Carriers.
@medpagetoday.com

#bcsm #hereditarycancer #womenshealth #medsky #genetics

🙌5th @hereditaryeu.bsky.social Meeting!
In our 3rd year, we are making strong progress in federated learning and analytics, advancing privacy-preserving multimodal health data analysis across Europe

🧬Proud that CNAG contributes to this European Project
#HorizonEurope #HereditaryCancer #CNAG

Learn more and register!

Learn about hereditary gyn cancer risk, treatment ＆ prevention! Join FORCE's Ask the Experts webinar with Drs. Frey ＆ Gerber (Weill Cornell) on Feb 25, 2026, 6:30 pm ET. Don't miss out! #gyncancer #hereditarycancer app.sosha.ai/s/yv0XtNUm

Learn more about hereditary cancer risk!

Your genes don't define you, but knowing about them can save your life. This #NationalCancerPreventionMonth, learn more about the signs that might point to an inherited gene mutation linked to cancer.

#HereditaryCancer #FacingOurRisk app.sosha.ai/s/GLtxBUYV

It is estimated that at least 1 in 279 people carry an inherited genetic mutation that puts them at risk of developing cancer. However, hereditary cancers are some of the most preventable. Genetic knowledge and genetic testing can save lives. Learn more at about hereditary cancer and how it might be prevented at www.genetionary.org.

Learn more about genetic mutations and hereditary cancer syndromes like Lynch Syndrome at Genetionary.org.

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#tumorsuppressorgenes #geneticmutations #DNA #HereditaryCancer #health #genetics #genes

We analyzed 17 BRCA1 and BRCA2 variants associated with hereditary breast and ovarian cancer to evaluate their impact on RNA splicing. Eight variants showed aberrant splicing, while nine had no spliceogenic effect, enabling improved variant classification. 🔬 This work contributes to refining the clinical interpretation of BRCA1 and BRCA2 variants and highlights the importance of combining experimental and computational evidence for genetic risk assessment. https://academic.oup.com/clinchem/advance-article/doi/10.1093/clinchem/hvaf177/8416539. https://doi.org/10.1093/clinchem/hvaf177. Epub ahead of print. PMID: 41499258.

✨ We are starting the year with great news! 🎉 Our new paper titled "Splicing predictions, splicing assays and variant classification using ACMG/AMP guidelines: challenges observed with BRCA1 and BRCA2 variants" has been published. 🧬
#Genetics #BRCA #HereditaryCancer #Splicing #ACMG #Research

Oral bacterium may promote breast cancer development and spread Researchers at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy found that an oral bacterium commonly associated with periodontal ...

New Study by John Hopkins researchers finds Fusobacterium nucleatum can drive #DNA damage, tumor growth & metastasis, with heightened effects in cells with #BRCA1 gene mutations @eurekalert.bsky.social

#bcsm #hereditarycancer #womenshealth #medsky #cancerresearch #genetics

Screenshot of the hereditary cancer information and awareness website, Genetionary.org

Genetionary.org is an ad-free site with a simple genetic mutation glossary with infographics and materials for sharing family health/cancer history.

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#DNA #health #cancer #HereditaryCancer #genetics #geneticmutations #familyhealth #BRCA

Pancreatic Cancer Therapy: What Comes Next? Dr Emil Lou breaks down what’s changing in pancreatic cancer care, including neoadjuvant chemotherapy, genomic testing, and why progress remains incremental.

Dr Emil Lou, medical oncologist & specialist in gastrointestinal cancers at the University of Minnesota talks about all things, updates, & advances in #pancreaticcancer , including #BRCA & #PARP therapies @medscape.com

#hereditarycancer #pancchat #medsky #genetics #pancsm

Nous-209 neoantigen vaccine for cancer prevention in Lynch syndrome carriers: a phase 1b/2 trial - Nature Medicine In a phase 1b/2 trial, an off-the-shelf vaccine using gorilla adenoviral and modified vaccinia Ankara vectors with over 200 mutated peptides known to be present in persons with mismatch-repair-deficie...

A #vaccine to prevent #coloncancer. Proof-of-concept for strong immune response and safety via neoantigens given to people with mutations for #Lynchsyndrome.

#hereditarycancer #genetics #medsky #cancerresearch

Genetic tumor syndromes in female cancer: insights into inherited cancer predisposition and clinical implications - Archives of Gynecology and Obstetrics A relevant proportion of malignancies predominantly or exclusively affecting women, including breast and gynecologic cancers, is attributable to hereditary tumor syndromes, profoundly impacting cancer...

This review provides a comprehensive overview of #hereditarycancer predisposing to breast and gynecologic malignancies, with a focus on genetic basis, associated cancer risks, and implications for clinical management.

#bcsm #gyncsm #genetics #womenshealth #cancerresearch #medsky

Save the Date! Join us for the first Y-InSiGHT webinar on career development for emerging professionals in hereditary GI tumours.

📅 28 January | 🕒 14:00 CET | 💻 Online

Register now and find more info 👉 shorturl.at/k773K

#YInSiGHT #HereditaryCancer #Genetics #GIOncology #EarlyCareerResearchers

#brca #hereditarycancer #genetics #patientexperience
#EarlyDetection #her2 #prostatecancer #breastcancer #cysticfibrosis #sicklecell #heartdisease #diabetes #pancreaticcancer

The Angelina Jolie Effect: A Lasting Global Impact on Cancer Prevention - OncoDaily “Angelina Jolie effect”: a measurable, sustained increase in genetic testing, cancer screening, and awareness worldwide.

The Angelina Jolie Effect: A Lasting Global Impact on #BRCA #HereditaryCancer Prevention. @oncodaily.bsky.social

#bcsm #gyncsm #genetics #womenshealth #medsky #patientexperience

No Increased Breast Cancer Risk With Menopausal Estrogen in BRCA Carriers Estrogen-only HRT tied to significantly lower risk, no adverse effect of combined hormones

No Increased #BreastCancer Risk With Menopausal Estrogen in #BRCA Carriers: Estrogen-only #HRT tied to significantly lower risk, no adverse effect of combined hormones.

Via @medpagetoday.com

#SABCS #hereditarycancer #womenshealth #bcsm #cancerresearch #medsky

The male breast cancer story of former San Diego Chargers defensive tackle, Tony Savage via My Faulty Gene.
Watch here: familygeneshare.org/T3140

#FamilyGeneShare #BRCA #ItsNotJustPink #MaleBreastCancer #SanDiegoChargers #MustWatch #HereditaryCancer #MensHealth

Myriad Genetics Announces Hereditary Cancer Risk Assessment Program Study Published in Obstetrics & Gynecology Myriad Genetics announced a hereditary cancer risk assessment program study was published in Obstetrics & Gynecology (also known as The Green Journal)....

Virtual tools are breaking down barriers to #genetictesting 📱💻

Myriad Genetics’ new study shows that #digitaleducation & at-home risk assessment significantly boost participation in #hereditarycancer screening.

First steps towards a targeted prostate cancer screening programme - Cancer Research UK - Cancer News The UK NSC's proposed screening programme would invite 45 to 61-year-old men with BRCA mutations for a PSA test every two years.

First steps towards a targeted #prostatecancer screening programme in the UK: If implemented, the proposal will invite men aged 45 - 61 with a mutation in the #BRCA genes for PC screenings every 2 years.

Via @cancerresearchuk.org

#hereditarycancer #genetics #menshealth #medsky #cancerresearch