U01.17.002 Lynch syndrome (HNPCC) U01.17.002 Summary: Explore the molecular basis of Lynch Syndrome. Understand the "Second Hit" hypothesis, the characteristic proximal colon location, and associated extracolonic malignancies like endometrial cancer.

Lynch Syndrome: The DNA Mismatch Defect
#USMLEStep1 #MedEd #Pathology #LynchSyndrome #HNPCC #Genetics #Step1Prep #HighYield #MedSchool #Gastroenterology #Oncology #DNArepair #EndometrialCancer #FutureDoctor #StudyGram #MedTwitter #Anki #BoardExams #MedicalStudent #FirstAid #MedicalSchool #PreMed #Ph

From the March 2026 issue: Deep intronic #MSH2 variant confirms #Muir-Torre subtype of #LynchSyndrome https://ow.ly/Wfm550XN5XC #medderm #dermsky

Back from the @ncicapit.org Summit! Honored to contribute to designing vaccines for cancer before it emerges. Advocates J. Ahlstrom @healthtreeorg.bsky.social, E. Krischner (Li-Fraumeni), & R. Dubin @aliveandkickn.bsky.social reminded us why this research matters #CancerPrevention #Lynchsyndrome

Driving Impact: CGA-IGC's 2026 Colorectal Cancer Awareness Month Campaign We were excited to once again serve as a resource for our members and the wider hereditary GI cancer community during the 2026 Colorectal Cancer Awareness Month. At CGA-IGC, our mission is to empower ...

💙 #ColorectalCancerAwarenessMonth united partners to raise awareness of a disease still impacting too many, especially younger🧑‍🤝‍🧑

🔍 Early detection matters, but disparities remain

🧬 We highlighted #LynchSyndrome & #FAP

📅 Explore our full campaign & weekly highlights 👇 🔗tinyurl.com/25meve8b

Mrinali Dhembla had Lynch syndrome; a genetic mutation that made her cancer highly vulnerable to immunotherapy. Knowing your genetic risk can save your life. Get tested. #TCSC #LynchSyndrome #CancerPrevention #KnowYourRisk

Colonoscopy #32, this year with upper endoscopy as it’s been three years. #lynchsyndrome #coloncancerawarenessmonth

Week 4 of #ColorectalCancerAwarenessMonth spotlights #LynchSyndrome 🧬 Learn more 👉tinyurl.com/bp8h9a3r

Drs. Loomans-Kropp & Foda are advancing research through the LINEAGE Consortium using pt-reported data to better understand real-world cancer ⚠️

📖 Blog 👇tinyurl.com/t575emh8
#HereditaryGICancer

Previvorship - Final report Final project report: Social media for carriers of hereditary cancer syndromes

Final project report: Social media for carriers of hereditary cancer syndromes. @stefaniavicari.bsky.social @leverhulme.ac.uk

www.previvorship.org/final-report

#BRCA #lynchsyndrome #socialmedia #research #hereditarycancer

LinkedIn This link will take you to a page that’s not on LinkedIn

Those interested in #Socialmedia in health care, check our this project Previvorship www.previvorship.org) report on Social Media for Carriers of Hereditary Syndromes lnkd.in/eds-kMDm #gyncsm #lynchsyndrome #BRCA #bcsm

🚨 Urgent - last chance to register - don't miss out!

👉 Join this free NHS educational session to explore #LynchSyndrome and setting up nurse-led clinics

✔️ CPD certificate
✔️ Practical takeaways
💻 Online | 🕘 9–10am | 📅 16 March
🔗 Sign up now bit.ly/49t9rkc

Another fantastic day at #InSiGHT2026 🔬

Day 3 highlighted major progress in hereditary GI cancers: From gastric & #PancreaticCancer updates to key advances in #LynchSyndrome. Great talks, global insights, and an excellent panel discussion.

#GICancerPrevention #MedicalResearch

Ready for Day 3 of #InSiGHT2026 ?👀

Don’t miss these exciting sessions:

🧬Session 7: Hereditary Gastric Cancer Surveillance and Management
🔬Session 8: Advances in Pancreatic Cancer Research
🧪Sessions 9 & 10: Advances in Lynch Syndrome Research

#InSiGHTCommunity #GIcancer #LynchSyndrome

Preventive vaccines for hereditary cancer syndromes - Nature Medicine An ‘off-the-shelf’ neoantigen vaccine shows safety and immunogenicity in individuals with Lynch syndrome, further advancing hopes for preventive vaccines for hereditary cancer syndromes.

An ‘off-the-shelf’ neoantigen #vaccine shows safety and immunogenicity in people with #Lynchsyndrome, advancing hopes for preventive cancer vaccines.
News & Views from Zsofia Stadler, Yonina Murciano-Goroff @ Memorial Sloan Kettering Cancer Center
https://www.nature.com/articles/s41591-026-04248-2

Preventive vaccines for hereditary cancer syndromes - Nature Medicine An ‘off-the-shelf’ neoantigen vaccine shows safety and immunogenicity in individuals with Lynch syndrome, further advancing hopes for preventive vaccines for hereditary cancer syndromes.

An ‘off-the-shelf’ neoantigen #vaccine shows safety and immunogenicity in people with #Lynchsyndrome, advancing hopes for preventive cancer vaccines.
News & Views from Zsofia Stadler, Yonina Murciano-Goroff @ Memorial Sloan Kettering Cancer Center
https://www.nature.com/articles/s41591-026-04248-2

📣 1 week until #ColorectalCancerAwarenessMonth! 💙

🧬 Read our blog on partnering with @FightCRC for #CRCAwarenessMonth, incl 🔵 United in Blue, 📍Volunteer Day (March 1, DC), 🚩 blue flags & 💪 #StrongArmSelfie.

Learn more & get involved 👉 tinyurl.com/y4rs69nb

#HereditaryGICancer #LynchSyndrome

🧬CIP-Net Project Spotlight: Immune determinants modulating cancer development in #LynchSyndrome
This project will define the shared frameshift neoantigens and T cell features that restrain progression from precancerous polyps to CRC.
👉https://nci-cipnet.org/en/members/ug3ca290517/

Your support for us enabled funding of this pioneering genetic test, hailed as a cancer ‘breakthrough’ by scientists - and demonstrating the vital importance of clinical trials. #LynchSyndrome

Thank you! 👏🏽

www.newcastle-hospitals.nhs.uk/news/doctors...

📢 Abstract deadline EXTENDED‼️
🧬 Lynch Syndrome Scientific Symposium 2026 @danafarber.bsky.social
📍 Boston | 🗓️ Apr 13, 2026
👩‍⚕️ Researchers & clinicians
💻 In-person + virtual

🚨 Last chance to submit an abstract
⏰ Deadline: Feb 20, 2026 (11:59 PM)

👉 Submit here: tinyurl.com/bdzj9vn5
#LynchSyndrome

🧬 Join the 5th Annual Lynch Syndrome Symposium
📅 Mar 10, 2026

💻 Virtual | 💸 Free | 🎓 CEU/CME included

A full day on the latest advances in #LynchSyndrome research & clinical care. Open to clinicians, pts & families
🔗 Info: tinyurl.com/yc48f5as
📝 Register: tinyurl.com/4dkeevbv

#HereditaryGICancer

Gene-specific cancer risks in female Lynch syndrome carriers: A copula-based meta-analysis Lynch syndrome, caused by germline pathogenic variants in mismatch repair genes, markedly increases risks of endometrial, ovarian, and possibly breast…

Gene-specific cancer risks in female #Lynchsyndrome carriers.

• #Endometrialcancer is most frequent in carriers of the MSH2 & MSH6 genes.

•PMS2 & MSH6 ⬆️ #breastcancer risk; MLH1/MSH2 are associated with ⬇️ risk.

• #Ovariancancer prevalence is 6.8% without significant gene-specific effects.

‘How I knew I had colorectal cancer’: Six survivors share their symptoms What are the symptoms of colorectal cancer, and when should you see a doctor? Gastroenterologist David Richards, M.D., weighs in on when to see a doctor, and six survivors share how they knew they had...

“How I knew I had colorectal cancer”
🦋Six survivors share their symptoms
#ColorectalCancer #ColonCancer #RectalCancer
#ColorectalCancerAwareness #ColonCancerAwareness
#GetScreened
#BlueForCRC
#DressInBlueDay
#CRCsm
#LynchSyndrome #Medsky #fuckcancer #Bluesky #ChronicIllness #art #oc #digitalart

LynchVax A Cancer Prevention Vaccine Programme.

🔗 Learn more about the LynchVax programme:
www.cancer.ox.ac.uk/research/lyn...

#WIMMSpotlight #WIMMCommunity #CancerResearch #Immunotherapy #ClinicalResearch #LynchSyndrome #PreventativeVaccines #MRCWIMM 🧬

🩺 20–30% reduced colorectal cancer risk after 5+ yrs aspirin.
💊 Lynch syndrome benefits at 100–600mg.
⚠️ Bleeding risk limits use.
📊 GLP-1 agonists may reduce risk more (observational).
#ColorectalCancerPrevention #Aspirin #LynchSyndrome #GLP1Agonists
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🧬 Lynch Syndrome Scientific Symposium | Apr 13, 2026

Hosted by Dana-Farber’s Lynch Syndrome Center in Boston (in-person & virtual)
📒👉 tinyurl.com/43775aaw
🚨 Abstract deadline - Feb 16, 2026 (11:59 PM EST)
🔗 Register & submit abstract: 👉 tinyurl.com/4fkmt43v

#LynchSyndrome #HereditaryGICancer

Nous-209 neoantigen vaccine for cancer prevention in Lynch syndrome carriers: a phase 1b/2 trial - Nature Medicine In a phase 1b/2 trial, an off-the-shelf vaccine using gorilla adenoviral and modified vaccinia Ankara vectors with over 200 mutated peptides known to be present in persons with mismatch-repair-deficie...

A #vaccine to prevent #coloncancer. Proof-of-concept for strong immune response and safety via neoantigens given to people with mutations for #Lynchsyndrome.

#hereditarycancer #genetics #medsky #cancerresearch

Immune-targeting vaccine shows promise intercepting cancer in patients with Lynch Syndrome The investigational cancer vaccine, NOUS-209, was found to safely stimulate the immune system to target precancerous and cancerous cells in individuals with Lynch Syndrome (LS), according to a study f...

Immune-targeting vaccine shows promise intercepting #cancer in patients with #LynchSyndrome
#Health

This is promising because it suggests the #immunesystem can be trained to eliminate precancerous lesions before they progress to #cancer. If confirmed in larger studies, NOUS-209 could expand prevention options for #Lynchsyndrome. www.linkedin.com/posts/drmelv...

Outcomes from the English National Lynch Syndrome transformation project The elevated cancer risk conferred by Lynch syndrome can be mitigated through preventive interventions. However, Lynch syndrome often goes underdiagnosed. The National Lynch Syndrome Transformation P...

Outcomes from the English National #LynchSyndrome transformation project: New diagnoses of LS have consistently increased each year from a total of 545 in 2020 to a total of 1394 in 2024 (an increase of 255% vs. a target of >50%).

onlinelibrary.wiley.com/doi/10.1002/...