#ScientistSpotlight

This week we’re featuring Cansu Dinçer, a computational postdoctoral scientist in the Sharma Group within the MRC Translational Immune Discovery Unit at the #MRCWIMM.

@rdm.ox.ac.uk @medsci.ox.ac.uk

#ScientistSpotlight 🧪

This week we’re introducing Yuqi Shen, a postdoctoral researcher at Beth Psaila Group here at the #MRCWIMM.

@yuqi-shen.bsky.social @bethpsaila.bsky.social @rdm.ox.ac.uk @medsci.ox.ac.uk #AkademicSky

#MethodMonday: Behind the scenes of #flowcytometry at the #MRCWIMM 🧪

Our cytometry facility supports hundreds of researchers each year, from training to troubleshooting and advanced sorting. This week, we highlight the team behind the facility, whose expertise makes this work possible.

#ScientistSpotlight 🧪

This week we’re featuring Karmella Naidoo, a postdoctoral researcher in the Graham Ogg Group at #MRCWIMM

#WIMMSpotlight #WIMMCommunity #CD1a #cutaneousimmunity #innateimmunology #itch #barriersensing #MRCWIMM #AcademicSky @rdm.ox.ac.uk @medsci.ox.ac.uk

New study reveals how blood cell production responds to parasite infection Research led by the Nerlov Group in the MRC Molecular Haematology Unit provides the first detailed explanation of how parasite-fighting immune cells are selectively increased following infection.

#WIMMReads
🧪 In a new Nature study, researchers from the Nerlov Group at the #MRCWIMM map how parasite infection reshapes blood cell production, boosting #parasite fighting immune cells.

The work also identifies a potential #drug target for allergic inflammation, asthma and mast cell disorders.

Protocol for stable cell line production to express muscle-type nicotinic receptor The adult muscle-type nicotinic acetylcholine receptor (AChR) is essential for neuromuscular transmission but is difficult to produce due to the requirement for coordinated subunit assembly. Here, we ...

Step-by-step protocol to make stable cell lines for large-scale expression of muscle-type nAChR (and other multi-subunit targets)!

By the inexhaustible and tenacious @annaliiiiiiii.bsky.social in collab with Dong group in #MRCWIMM and @cmd.ox.ac.uk

www.cell.com/star-protoco...

#ScientistSpotlight 🧪

This week we’re featuring Paula Gomez Castro, a #DPhil student in the Simmons Group at #MRCWIMM.

@rdm.ox.ac.uk @medsci.ox.ac.uk @ox.ac.uk #AcademicSky

Today we remember our founder, Professor Sir David Weatherall, on his birthday 🧪

His vision of #collaboration continues to shape #MRCWIMM, and we are proud to carry his legacy forward.

@rdm.ox.ac.uk @medsci.ox.ac.uk @ox.ac.uk

This Sunday is #InternationalWomensDay 🧪
Each year we take our Women of WIMM group photo, celebrating women across our entire community, from research and technical teams to professional services.

Here is to the women of #MRCWIMM.

@rdm.ox.ac.uk @medsci.ox.ac.uk @ox.ac.uk

#ScientistSpotlight 🧪

This week we’re featuring Toby Whitehead, a DPhil student in the Sharma and Davis Labs at the #MRCWIMM.

@rdm.ox.ac.uk @medsci.ox.ac.uk @ox.ac.uk

#WIMMSpotlight #WIMMCommunity #Immunology #CancerResearch #Immunotherapy #TCells #CheckpointBiology #AcademicSky

Tomorrow is #RareDiseaseDay

Behind every rare disease diagnosis is a person and a family looking for answers. 🧪🧬

Rare diseases are a core focus at #MRCWIMM, driving research that aims to deliver real impact for patients.

@rarediseaseday.bsky.social @rdm.ox.ac.uk @medsci.ox.ac.uk @ox.ac.uk

Spatiotemporal analysis of human intestinal development at single-cell resolution Development of the human intestine is not well understood. Here, we link single-cell RNA sequencing and spatial transcriptomics to characterize intest…

📄 Key paper on single cell RNA sequencing and spatial transcriptomics in fetal intestine:
www.sciencedirect.com/science/arti...

#WIMMSpotlight #WIMMCommunity #PaediatricResearch #IntestinalImmunology #SpatialTranscriptomics #SingleCellGenomics #RareDiseaseResearch #MRCWIMM

#MethodMonday 🧪
Meet the #Imaging Facility at the #MRCWIMM
With over 15 years of expertise each, our two MRC WIMM imaging specialists maintain the instruments and support researchers working with a diverse range of research questions and imaging demands.

@medsci.ox.ac.uk @rdm.ox.ac.uk #AcademicSky

A double helix twist in HIV vaccine design DNA origami scaffolds displaying HIV antigens stimulate focused antibody responses in mice

#WIMMReads
🧪 A new Science commentary from #MRCWIMM 's Oliver Bannard highlights how #DNA origami scaffolds could help focus antibody responses in #HIV #vaccine design, offering new directions for broadly protective immunity.
@ndm.ox.ac.uk @medsci.ox.ac.uk

#HIVResearch #Immunology #AcademicSky

Katie Croft MPhys (Hons) Katie Croft - DPhil Student

🔗 Learn more about Katie’s work:
www.imm.ox.ac.uk/people/katie...

#WIMMSpotlight #WIMMCommunity #StemCellResearch #Haematopoiesis #AgeingResearch #ComputationalBiology #MRCWIMM

#ScientistSpotlight 🧪

This week we’re featuring Katie Croft, a #DPhil Student in the Claus Nerlov Lab at the #MRCWIMM.

#AcademicSky @rdm.ox.ac.uk @medsci.ox.ac.uk

#MethodMonday 🧪:
How is #imaging used in research at the #MRCWIMM?

Scientists choose microscopes to image specimens and to measure, track, and record changes during development, disease progression, or drug treatment.

#AcademicSky @rdm.ox.ac.uk @medsci.ox.ac.uk

Switching and Sniffing around the β-globin cluster In this issue of Blood, Bagchi et al1 show how the β-like globin genes may be regulated by “Switch-Sniff” (switch/sucrose nonfermentable) chromatin remodel

#WIMMReads
🧪 #MRCWIMM Professor Doug Higgs authors a commentary in Blood on how chromatin remodeling complexes regulate globin genes and what this could mean for reactivating fetal hemoglobin in beta thalassemia and sickle cell disease.
#Haematology #GeneRegulation #WIMM

🧪Celebrating #WomenInScienceDay with just a few of the brilliant women who make research happen at the #MRCWIMM.

Science is stronger when talent is recognised, supported and visible.

#WomenInScience #WomenInSTEM

Laura Ciacchi Laura Ciacchi - Postdoctoral Scientist

🔗 Find out more:
RDM profile: www.rdm.ox.ac.uk/people/laura...

#WIMMSpotlight #WIMMCommunity #Immunology #SkinImmunity #TCells #LipidBiology #UVResearch #MRCWIMM

#ScientistSpotlight 🧪

This week we’re featuring Laura Ciacchi, a postdoctoral scientist at the #MRCWIMM and a recent recipient of an HFSP early career fellowship.

@rdm.ox.ac.uk @medsci.ox.ac.uk

Congenital myasthenic syndrome: is it time for a name change to genetic myasthenic syndrome? Ramdas et al. propose renaming ‘congenital myasthenic syndrome’ as ‘genetic myasthenic syndrome’. They argue that ‘congenital’ misleadingly implies neonata

#WIMMReads 🧪

#MRCWIMM Group Leader Yin Dong is among clinicians and scientists with expertise in congenital #MyasthenicSyndrome suggesting it may be time to update the disease name to reduce misdiagnosis and improve care.
#Neurology #RareDisease

@ndcnoxford.bsky.social @medsci.ox.ac.uk

Platelets shown to store DNA in study that could transform cancer screening Study led by Psaila Group uncovers previously unknown function of platelets as DNA ‘vacuum cleaners’ in the blood, with profound implications for cancer diagnosis and prenatal screening.

#WorldCancerDay Discovery and early detection matter 🧪

Research at #MRCWIMM shows that platelets carry #DNA, offering new insights into cancer biology and early detection through fundamental science.

#CancerResearch #EarlyDetection
@bethpsaila.bsky.social @rdm.ox.ac.uk @ox.ac.uk @medsci.ox.ac.uk 🧬

New ‘off-the-shelf’ immunotherapy shows promise for treating high-risk childhood leukaemia Scientists at the University of Oxford, together with colleagues at Imperial College London and the University of Glasgow, have developed a new type of immunotherapy that could improve outcomes for in...

#WorldCancerDay | When time matters, waiting is not an option.

Researchers at #MRCWIMM have developed a readily available immunotherapy approach that showed promise against difficult to treat childhood #leukaemia in early stage #research. 🧪

#ChildhoodCancer #CancerResearch

At the #MRCWIMM, #CancerResearch one of our five core research areas. Across the institute, researchers are focused on understanding disease, improving detection, and developing new approaches to treatment, always with people at the heart of science.

LynchVax A Cancer Prevention Vaccine Programme.

🔗 Learn more about the LynchVax programme:
www.cancer.ox.ac.uk/research/lyn...

#WIMMSpotlight #WIMMCommunity #CancerResearch #Immunotherapy #ClinicalResearch #LynchSyndrome #PreventativeVaccines #MRCWIMM 🧬

At the #MRCWIMM several types of different light microscopes are used to visualise cellular defects, interactions, and processes that are invisible to the naked eye, helping researchers understand what is happening inside a complex system.

#LightMicroscopy #WIMMResearch #CellImaging

Rehwinkel Group: Nucleic Acid Sensing

🔗 Rehwinkel Group lab page:
www.rdm.ox.ac.uk/about/our-di...

#WIMMSpotlight #WIMMCommunity #Immunology #InnateImmunity #AntiviralResearch #Interferon #PhDStudent #MRCWIMM

Through her work, Alison helps ensure that scientific advances are understood not just in the lab, but in the real-world contexts where they matter most.

#WIMMSpotlight #WIMMCommunity #HealthExperienceResearch #GeneticCounselling #PublicEngagement #ScienceAndSociety #MRCWIMM

#ScientistSpotlight 🧪
Meet Alison Kay, a health experience researcher at the #MRCWIMM. Alison works with scientists to understand how molecular discoveries affect clinicians, patients, and families in real life.

@rdm.ox.ac.uk
@medsci.ox.ac.uk
@genomics-ali.bsky.social 🧬