Today is closing day of the #SITC 2026 Spring Scientific. It has been an incredible week. Amazing science, intriguing presentations, powerful keynote address and relationship building through opportunities for networking.
A BIG shout out to our organizers!
#SITCQuestfor100 #TCells #Immunotherapy

dianova Anti-TIGIT (Hu) Clone TG1 is the first monoclonal antibody detecting #TIGIT in routine #FFPE tissue specimen by #IHC.

Validated for the identification of TIGIT positive #Tcells infiltrating human #tumours under pathological conditions.

www.stratech.co.uk/p...

In vivo treatment with 1C5 prolongs skin allograft survival. Left: Schematic representation of the experimental procedures. Right: Wild-type C57BL/6 mice were i.p. injected 4 times with 250 µg 1C5 or C6 once in a week, followed by transplantation of ear skin from BALB/c mice. CyA (20 mg/kg) was injected every day after transplantation until the graft was rejected. Alloreactive IgG in sera was measured by FCM (top right). Mean ± SD are shown (n = 5). Data were analyzed by two-way ANOVA with Šidák multiple comparison test. Bottom right: graft survival curves (n = 20) are shown.

Autoimmune diabetes & #transplant rejection arise when immune checkpoints fail. This study shows that blocking CD22 ligand-binding expands regulatory #Bcells & protective γδ #Tcells, suppressing type 1 #diabetes & prolonging #SkinGraft survival in mice @plosbiology.org 🧪 plos.io/41t4KTS

In vivo treatment with 1C5 prolongs skin allograft survival. Left: Schematic representation of the experimental procedures. Right: Wild-type C57BL/6 mice were i.p. injected 4 times with 250 µg 1C5 or C6 once in a week, followed by transplantation of ear skin from BALB/c mice. CyA (20 mg/kg) was injected every day after transplantation until the graft was rejected. Alloreactive IgG in sera was measured by FCM (top right). Mean ± SD are shown (n = 5). Data were analyzed by two-way ANOVA with Šidák multiple comparison test. Bottom right: graft survival curves (n = 20) are shown.

Autoimmune diabetes & #transplant rejection arise when immune checkpoints fail. This study shows that blocking CD22 ligand-binding expands regulatory #Bcells & protective γδ #Tcells, suppressing type 1 #diabetes & prolonging #SkinGraft survival in mice @plosbiology.org 🧪 plos.io/41t4KTS

In vivo treatment with 1C5 prolongs skin allograft survival. Left: Schematic representation of the experimental procedures. Right: Wild-type C57BL/6 mice were i.p. injected 4 times with 250 µg 1C5 or C6 once in a week, followed by transplantation of ear skin from BALB/c mice. CyA (20 mg/kg) was injected every day after transplantation until the graft was rejected. Alloreactive IgG in sera was measured by FCM (top right). Mean ± SD are shown (n = 5). Data were analyzed by two-way ANOVA with Šidák multiple comparison test. Bottom right: graft survival curves (n = 20) are shown.

Autoimmune diabetes & #transplant rejection arise when immune checkpoints fail. This study shows that blocking CD22 ligand-binding expands regulatory #Bcells & protective γδ #Tcells, suppressing type 1 #diabetes & prolonging #SkinGraft survival in mice @plosbiology.org 🧪 plos.io/41t4KTS

Welcome to the 2026 #SITC #Sparkathon participants (Sparkies). We would like to thank them for participating in this unique program to advance their careers in immuno-oncology! #TCells #IO #SITCQuestfor100

See you at the #AAIC2026 as it will be my first AD #conference presenting our work on #Adaptive #immunity #Tcells in #Alzheimer #disease @alzheimerssoc.bsky.social

HIF-1α+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung A deeper understanding of how tissue-localized immune cells arise and function is critical for developing mucosal vaccines. Currently, there are no mu…

A hidden immune network inside the lung: @biomedizin.unibas.ch scientists reveal how T cells coordinate local defense against infection and cancer.
👉 www.sciencedirect.com/science/arti...

@immunologyking.bsky.social #Immunology #LungImmunity #Tcells #ImmuneSystem #Influenza #CancerImmunology

Scientists “turbocharge” immune cells to attack prostate cancer – BioNews Central A new class of engineered, supercharged T cells is stronger, longer-lasting, and more precise at killing prostate cancer cells by fine-tuning how they physically interact with tumor cells. ...

A new class of engineered, supercharged #TCells is stronger, longer-lasting, and more precise at killing #ProstateCancer cells by fine-tuning how they physically interact with #TumorCells.
#ProstateCancerTreatment #CancerImmunotherapy #EngineeredTCells

EDITORS’ CHOICE: Single-cell transcriptomics reveal intrinsic and systemic T cell aging in COVID-19 and HIV - Aging-US Research In this study, titled "Single-cell transcriptomics reveal intrinsic and systemic T cell aging in COVID-19 and HIV" and published in Volume 18 of Aging-US, researchers used single-cell RNA sequencing t...

⭐ #EditorsChoice:
“Single-cell transcriptomics reveal intrinsic and systemic T cell aging in COVID-19 and HIV.”

🔗 Read the Editors’ Choice feature:
aging-us.org/2026/03/edit...

#aging #research #HIV #COVID #Tcells #openaccess #openscience #peerreviewed #journal #publishing #meded

🛡️ Your immune system has two completely different operating modes, and understanding both actually changes how you think about your health. The innate immune system is your fast, general-purpose first responder — it reacts immediately to anything foreign.

#ImmuneSystem #TCells

Immunity to a Common Virus Could Help Treat Tumors Injecting viral peptides systemically into mice activated immune cells that then targeted pancreatic tumors, opening avenues to more accessible cancer therapy.

Great new article from @thegeekygoth.bsky.social —

Here's how LJI and @ucsdhealth.bsky.social researchers are using viral peptides to combat pancreatic cancer!

bit.ly/46WA6pg #CancerResearch #Health #Medicine #SanDiego #Oncology #Tcells #PancreaticCancer #Immunotherapy

Scientists have long known that the Epstein–Barr virus (#EBV) is linked to multiple sclerosis (#MS). New UCSF research shows that EBV-reactive CD8+ “killer” #Tcells accumulate in the #CNS of people with MS, revealing how EBV may trigger immune-mediated damage.

www.sciencedaily.com/releases/202...

EDITORS’ CHOICE: Single-cell transcriptomics reveal intrinsic and systemic T cell aging in COVID-19 and HIV - Aging-US Research In this study, titled "Single-cell transcriptomics reveal intrinsic and systemic T cell aging in COVID-19 and HIV" and published in Volume 18 of Aging-US, researchers used single-cell RNA sequencing t...

⭐ #EditorsChoice:
“Single-cell transcriptomics reveal intrinsic and systemic T cell aging in COVID-19 and HIV.”

🔗 Read the Editors’ Choice feature:
aging-us.org/2026/03/edit...

#aging #research #HIV #COVID #Tcells #openaccess #openscience #peerreviewed #journal #publishing #meded

CD200R1 promotes the development of murine γδ17 T cells CD200R1 supports the development of murine IL-17–producing γδ T cells.

New data from Holly Linley, Amy Saunders and colleagues @lydiabeckeriii.bsky.social @manchester.ac.uk shows that "#CD200R1 promotes the development of murine #γδ17 #Tcells"

Tictock: A Single-Cell Clock Measures Immune Aging in Viral Infections - Aging-US Research Aging reshapes the immune system in two fundamental ways: it alters the proportions of different immune cell types circulating in the blood, and it induces molecular changes within each individual cel...

✅ Read our #blog post about the #research paper, titled "Single-cell transcriptomics reveal intrinsic and systemic T cell aging in COVID-19 and HIV."

#Summary ⬇️
aging-us.org/2026/03/tict...

#aging #HIV #COVID #Tcells #oa #openscience #peerreviewed #journal #publishing #meded

#ScientistSpotlight 🧪

This week we’re featuring Toby Whitehead, a DPhil student in the Sharma and Davis Labs at the #MRCWIMM.

@rdm.ox.ac.uk @medsci.ox.ac.uk @ox.ac.uk

#WIMMSpotlight #WIMMCommunity #Immunology #CancerResearch #Immunotherapy #TCells #CheckpointBiology #AcademicSky

The virus nearly everyone has and its possible role in MS | The-14 Nearly everyone carries Epstein-Barr virus, but research suggests it may trigger multiple sclerosis, opening new paths for prevention and treatment.

The virus nearly everyone has and its possible role in MS
#Health #MultipleSclerosis #MS #EpsteinBarrVirus #EBV #Neurology #Immunology #BrainHealth #Autoimmune #Science #PublicHealth #Inflammation #BCells #TCells #Healthcare #DiseasePrevention
the-14.com/the-virus-ne...

#Covid #TCells #HIV #MedSky💉

Cancer treatment: Optimization of CAR T-cell therapy – BioNews Central Researchers improve the efficacy of CAR T-cell therapy in solid tumors by modifying T cells to make them resistant to local inhibition within the tumor microenvironment. ...

Researchers improve the efficacy of #CARTCellTherapy in #SolidTumors by modifying #TCells to make them resistant to local inhibition within the #TumorMicroenvironment.
#CancerTreatment

New Single-Cell Transcriptomic Clock Reveals Intrinsic and Systemic T Cell Aging in COVID-19 and HIV - Aging-US Authors A new research paper was published in Volume 18 of Aging-US on February 8, 2026, titled “Single-cell transcriptomics reveal intrinsic and systemic T cell aging in COVID-19 and HIV.”

📈 #TrendingWithImpact:
This #research paper was #published in Volume 18, titled "Single-cell transcriptomics reveal intrinsic and systemic T cell aging in COVID-19 and HIV."

#PressRelease ⬇️
aging-us.net/2026/02/19/n...

#aging #HIV #COVID #Tcells #oa #journal #publishing #press

How vaccines give our immune systems a home advantage | The-14 How vaccines train our immune system’s front-line and adaptive defenses, building lasting protection and giving the body a crucial home advantage.

How vaccines give our immune systems a home advantage
#Health #Vaccines #Immunity #ImmuneSystem #TCells #Microbiology #Medicine #InfectiousDiseases #Measles #COVID19 #mRNA #Vaccination #PreventiveCare #DiseasePrevention #GlobalHealth
the-14.com/how-vaccines...

Engineered extracellular vesicles reprogram T cells by targeting PD-1 and PHB1 signaling, offering new therapeutic strategies for inflammatory bowel disease.
doi.org/10.1038/s413...
#InflammatoryBowelDisease #TCells #ExtracellularVesicles #PD1 #Immunotherapy

🧠CD38 Shields #CNS Tregs From Post-Inflammatory Stress. The study shows that regulatory #Tcells persist in the CNS after the acute phase and are essential to prevent local relapses.

🔗Read a summary of the study on our website: www.synergy-munich.de/aktuelles/ne...

This Genetic Discovery Could Make T Cells Unstoppable Scientists uncover a new “recipe” that shows how exhausted T cells can be reprogrammed to regain their ability to attack tumors.

This Genetic Discovery Could Make T Cells Unstoppable #Science #Biology #Genetics #GeneTherapy #TCells #CancerResearch

scitechdaily.com/this-genetic-discovery-c...

Laura Ciacchi Laura Ciacchi - Postdoctoral Scientist

🔗 Find out more:
RDM profile: www.rdm.ox.ac.uk/people/laura...

#WIMMSpotlight #WIMMCommunity #Immunology #SkinImmunity #TCells #LipidBiology #UVResearch #MRCWIMM

Spatial proteomic image of a lung tumour depicting the immune niche (blue, pink, purple cells) in which CD14+CD4+ T cells reside within the tumour. Tumour cells are coloured in grey.

Using spatial multi‑omics, WEHI scientists have uncovered an unusual population of CD14⁺CD4⁺ T cells in lung tumours, with higher levels linked to poorer patient outcomes.

New study out in @cp-cellrepmed.bsky.social

👉 www.cell.com/cell-reports...

#Cancer #SpatialOmics #TCells

🔬Dianova Anti-TIGIT (Hu) Clone TG1 is the first monoclonal #antibody detecting #TIGIT in routine #FFPE tissue specimen by #IHC

Validated for the identification of TIGIT positive #Tcells infiltrating human #tumours under pathological conditions

🔗www.stratech.co.uk/p...

CD44 is the central traffic controller for immune system function. 🚦 A new @nature.com article finds that when viruses like cytomegalovirus hijack this system, it can impede efficient priming of naive #TCells and the initiation of antiviral CD8 T cell responses.

Learn more: https://bit.ly/3NX2BfL

We kicked off 2026 with our first #CeMMinar featuring David Masopust (UMN Medical School), who shared insights on CD8 #TCells surveillance, migration & memory. Thanks to David & our hosts CeMM PI Clarissa Campbell & Adjunct PI @andreasbergthaler.bsky.social! 👏
#Immunology