The capacity of vaccine induced immunological memory, a stellar open-access review by @profshanecrotty.bsky.social www.cell.com/immunity/ful...

We’re taking a closer look at immune ‘memory’ Vaccines teach the body to fight disease. We still have a lot to learn about how long that immune

According to the WHO, vaccine-induced immunity saves about six lives every minute.

But how long does this protective immune “memory” last?

LJI Prof. Shane Crotty (@profshanecrotty.bsky.social) shares a comprehensive review on immune memory: bit.ly/3OD9svC

@cp-immunity.bsky.social #Immunology

My new comprehensive review of Immune Memory to Vaccines is out! It has an emphasis on human vaccines. It is also accompanied by a full video lecture. Enjoy!
@lji.org @cp-immunity.bsky.social
authors.elsevier.com/sd/article/S...

Answering big questions about the new flu and SARS-CoV-2 viral variants An immunology perspective on the influenza

LJI scientists are answering big questions about the new #flu and SARS-CoV-2 viral variants!

🤒 What's the difference between the new flu variant and a "super flu?"

🦠 Are #COVID19 cases going to be more severe?

Get the #immunology perspective: bit.ly/4cm2IKy

#Health #Medicine #Virology #Tcells

🎙 The Longevity Connection: Inflammation, Autoimmunity, and the Future of a Healthy Lifespan YouTube video by La Jolla Institute for Immunology

🏥 Why are women so much more likely to develop autoimmune diseases such as #Lupus and #MultipleSclerosis?

LJI's Dr. Sonia Sharma is investigating connections between genetics, aging, and the immune system: youtube.com/shorts/fAybB...

#Health #Medicine #ImmuneSystem #Inflammation #Aging

Prostate cancer is common, yet immunotherapy has been difficult to apply effectively.

New research maps how tissue‑resident memory T cells are organized inside the prostate, revealing location‑specific roles in immune defense and memory.

In collaboration with @lji.org & @ucsandiego.bsky.social

LJI scientists take a closer look at how male and female immune systems fight a common virus: bit.ly/4e7R6Ny

#Immunology #Health #Medicine #Virology @remimarrocco.bsky.social

We are headed to @aai.org soon!! Stop by our posters to chat about our latest work 🧑‍🔬 See you there: @hipcproject.bsky.social @airr-knowledge.bsky.social @cedar-epitopes.bsky.social ⭐️✨💫 #AAI2026 #immunology

LJI will receive up to $17.6 million to support critical database for biomedical innovation The Immune Epitope Database will continue to expand, thanks to renewed funding from the NIAID

The NIH's National Institute of Allergy and Infectious Diseases has announced it will fund LJI scientists up to $17.6 million to support the Immune Epitope Database (@iedb.bsky.social) for the next 5 years:

bit.ly/4sjorso

@bjoernpeters.bsky.social @settelab.bsky.social #Immunology

Scientists discover how key immune cells protect the prostate New research suggests we might boost immune cells to improve prostate health

News: Scientists have discovered that protective T cells travel to the prostate to establish residency and guard against infectious disease.

bit.ly/3Or84vX

@alleninstitute.org @ucsdhealthsci.bsky.social @reinacampos.bsky.social #Health #Medicine #ProstateCancer #Tcells

My publications - Moores Cancer Center Annual Impact Report FY25 - Page 28-29 M O O R E S R E S E A R C H C O L L A B O R AT I O N UCSD X LJI UNITING TO BOOST THE POWER OF MEMORY T CELLS In San Diego, scientific discovery does not happen

What happens when great research institutions join forces? 🔬

In its FY25 Annual Impact Report, the @ucsandiego.bsky.social Moores Cancer Center highlighted the power of collaboration across the mesa, including its partnership with LJI: bit.ly/3OfzGEh

#SanDiego #LaJolla #Health #Medicine

Exposing tumors: Why some cancers are especially hard to treat Some tumors go into

New on the LJI Blog —

Some tumors go into "stealth mode." Here's how scientists are fighting back: bit.ly/4v7lC0d

#Cancer #CancerImmunotherapy #Virology #Health #Medicine

Photo of four people sitting in front of an audience for a recent LJI "Life Without Disease" panel. Text overlays the photo. It reads: The Pandemic We Didn't See. Mechanisms, Myths, and What We Actually Know About Long COVID and Post-Viral Disease"

Experts recently gathered for an LJI panel on "The Pandemic We Didn't See" — about current research (and misconceptions) surrounding #LongCOVID and post-viral disease.

Catch the conversation—
📽️ YouTube: bit.ly/4mco3dN
👂 Spotify: bit.ly/4dRqOPt

#health #medicine #immunology #ChronicDisease

We were fortunate to bring together #LongCOVID experts at our latest "Life Without Disease" event.

By studying this disease from every angle, we're making progress in understanding how viral infections can trigger long-term health conditions. #COVID #AutoimmuneDisease #PostViralDisease

Another great speaker @gottschalklab.bsky.social coming to @lji.org. Come join!

So much fun hosting students from Canyon Hills High School last Friday 🤩

These bright young minds heard from some of our incredible researchers and toured our lab spaces, getting a closer look at science in action! 🧪 #STEM #STEMCareers #SanDiego #LaJolla #Science #Immunology

Join us on March 19, 2026, for a Life Without Disease event featuring LJI Associate Professor Sonia Sharma, Ph.D., UC San Diego Health cardiologist Pam Taub, M.D., FACC, FASPC, and award-winning health journalist Jason Gale. Dive into the science of post-viral diseases and learn about the urgent efforts to help patients recover from long COVID. This panel discussion will be moderated by LJI Professor, President & CEO Erica Ollmann Saphire, Ph.D., MBA. Join us after the panel for refreshments and a signing of Jason Gale's book: After Covid. The Health Impacts That Will Last Generations.

This week is Long COVID Awareness Week, so we're taking a close look at this #ChronicDisease, which affects ~ 27% of COVID survivors.

Want to learn more? Check out our Mar. 19 "Life Without Disease" event at LJI. Info here: bit.ly/4blRy92

#health #medicine #SanDiego #LaJolla #COVID19

Sex Differences in Metabolite–Immune Circuits of Neuroinflammation Sex is a fundamental yet underexplored determinant of human neuroinflammation. Across autoimmune, neurodegenerative, and post-infectious neurological syndromes, males and females exhibit consistent d...

New review from LJI's Sharma Lab —

"We highlight key knowledge gaps and discuss how targeting metabolite–immune pathways may enable sex-informed biomarkers and therapeutic strategies in neuroinflammatory disease."

onlinelibrary.wiley.com/doi/10.1111/... #health #immunology #ImmuneSystem

Study Finds Link Between Deoxyguanosine Kinase Deficiency and Immune Activation in Liver Research shows DGUOK deficiency, a mitochondrial disorder like TK2d, reprograms hepatocellular metabolism and triggers innate immune signaling in the liver.

Deoxyguanosine kinase deficiency is a rare disease that damages the liver, brain, and muscles—beginning in infancy.

Now LJI scientists have uncovered a critical mechanism behind the disease: bit.ly/4rtdVyp

#Preprint #ImmuneSystem #Immunology #RareDisease #Health #Medicine

Immunity to a Common Virus Could Help Treat Tumors Injecting viral peptides systemically into mice activated immune cells that then targeted pancreatic tumors, opening avenues to more accessible cancer therapy.

Great new article from @thegeekygoth.bsky.social —

Here's how LJI and @ucsdhealth.bsky.social researchers are using viral peptides to combat pancreatic cancer!

bit.ly/46WA6pg #CancerResearch #Health #Medicine #SanDiego #Oncology #Tcells #PancreaticCancer #Immunotherapy

Grand Rounds

Grand Rounds Speaker Bio

Tomorrow: We welcome Pandurangan Vijayanand, M.D., Ph.D., to PCCSM&P Grand Rounds! #MEDTWITTER #MEDED #Asthma
@ucsdhealthsci.bsky.social @ucsdmedschool.bsky.social @lji.org

Sex Differences in Metabolite–Immune Circuits of Neuroinflammation Sex is a fundamental yet underexplored determinant of human neuroinflammation. Across autoimmune, neurodegenerative, and post-infectious neurological syndromes, males and females exhibit consistent d...

🧠 Why do many neurological conditions, such as MS and Alzheimers, affect men and women differently?

In a new review, LJI Associate Prof. Sonia Sharma shows how sex-based differences in the immune system may make a difference onlinelibrary.wiley.com/doi/10.1111/...

#health #ImmuneSystem #Immunology

Rotavirus is a leading cause of life-threatening diarrhea in young children.

In a new paper, LJI scientists and study leaders at @ucsdhealth.bsky.social examine how rotavirus vaccination equips T cells to fight rotavirus infection: www.nature.com/articles/s41...

#health #medicine #immunology

LJI Instructor Haoyang Li receives $4.5M to pursue innovative therapeutics for cancers, infectious diseases, and chronic inflammation Li will capture key immune system molecules in action, with a new R01 grant from the National Institute of Allergy and Infectious Diseases

News: LJI Instructor Haoyang Li receives $4.5M to pursue innovative therapeutics for cancers, infectious diseases, and chronic inflammation

bit.ly/4rTU50k

@niaidnews.bsky.social #immunology #ChronicDisease #CancerImmunotherapies #InfectiousDisease #CryoEM

Processing power Meet the LJI scientists changing medical research through artificial intelligence

Forget ChatGPT and Gemini.

“We don’t have that kind of error tolerance."

Here's how LJI scientists are building new AI tools to advance medical research: mag.lji.org/fall2025/pro...

#DataScience #CompBio #AI #ChatGPT

Dr. Sette currently speaking on how the IEDB’s and CEDAR’s tools can support the development and testing of biologics #festivalofbiologicsUSA

New in @cp-cell.bsky.social — Researchers combine 3D genome organization + RNA processing to shed light on mysterious nuclear "speckles."

doi.org/10.1016/j.ce...

#Health #Medicine #Biology #CellularBiology #Imaging

Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social
doi.org/10.1016/j.ce...
Read the thread👇 for the highlights of our findings.

A tale of co-evolution: Nuclear speckles aid GC-rich RNA processing Researchers discover how mysterious cell structures nicknamed

Researchers from Max Planck Institute for Molecular Genetics, in collaboration with scientists from LJI and Kyoto University, have discovered how mysterious cell structures nicknamed “speckles” help our cells stay healthy.

bit.ly/4kWMb3A @cp-cell.bsky.social #CellBiology #MolecularBiology

The (microbe) highway to the danger zone LJI Professor Mitchell Kronenberg shows how immune cells defend your most vulnerable organs. His discoveries recently earned top recognition from the American Academy of Microbiology.

Your airways and your gut are high-traffic areas for the microbes of the world. 🦠

For more than 40 years, LJI's Mitchell Kronenberg has studied the T cells that step up to defend our most vulnerable organs.

Now Kronenberg has been elected fellow of the AAM: bit.ly/4rBrcps

@asm.org #microbiology