New video summary on the study "DNA-PK interacts with cyclic dinucleotides and inhibits type I #interferon responses," from Isabelle K. Vila, Yasmine Messaoud-Nacer, @nadinelaguette.bsky.social and colleagues (rupress.org/jem/article/...)
Video by Yasmine Messaoud-Nacer 📽️ youtu.be/cYfmJvV_jjk

DNA-PK interacts with cyclic dinucleotides and inhibits type I #interferon responses. From Isabelle K. Vila, Yasmine Messaoud-Nacer, Clara Taffoni, Dimitrios Vlachakis, Nadine Laguette @nadinelaguette.bsky.social @igmm-montpel.bsky.social and colleagues:
rupress.org/jem/article/...
#InnateImmunity

In @jhumimmunity.org, David, Frémond @institutimagine.bsky.social et al. identify a heterozygous P2RY8 E323G substitution in a father and son with cutaneous #lupus and enhanced type I #interferon signaling supports a role for P2RY8 in lupus causation rupress.org/jhi/article/...

David, Frémond @institutimagine.bsky.social et al. identify a heterozygous P2RY8 E323G substitution in a father and son with cutaneous #lupus and enhanced type I #interferon signaling supports a role for P2RY8 in lupus causation rupress.org/jhi/article/...

Exogenous #EBNA1 promotes #ImmunotherapyResistance by enhancing #ADAR1 translation via the IGF2BP3/EIF4G1 complex, suppressing #Interferon signaling and #ImmuneResponse in #EBV-associated cancers.

#STTT #OpenAccess: doi.org/10.1038/s413...

Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increa...

@cp-cell.bsky.social is on 🔥 with #immunemetabolism! Zheng &co show that excessive glycolysis-driven pyrivate cause pyruvylation of STAT1 preventing #interferon signaling 👉 doi.org/10.1016/j.ce... & Finley &co show that ACO2 clears citrate preventing integrated stress response & kidney degeneration👇

Interferon stimulation and NKG2D expression drive enhanced natural killer cell antibody-dependent cellular cytotoxicity against viral infections Integrated single-cell transcriptomics and functional assays reveal interferon signaling and NKG2D expression as drivers of antibody-dependent cellular cyt

Leslie Chan @stanfordimmunology.bsky.social, Catherine Blish @blishlab.bsky.social and colleagues @stanfordmedicine.bsky.social identify #Interferon activation and #NKG2D expression as key determinants of #NKcell antibody-dependent cellular cytotoxicity (#ADCC) in #SARS-CoV-2 infection

Epigenetic dysregulation of IRF9 drives excessive #interferon signaling in #COPD

By M. Llamazares-Prada, R. Jurkowska & colleagues @biomedx.bsky.social & Cardiff University

🗞️ doi.org/10.1038/s44321-026-00386-9

In the final stretch of my DPhil at @ox.ac.uk, working on how the soluble interferon receptor IFNAR2a modulates type I interferon signalling in infection and autoimmunity.

Excited to see where this work leads next!

#Immunology #InnateImmunity #Interferon

Rehwinkel Group: Nucleic Acid Sensing

🔗 Rehwinkel Group lab page:
www.rdm.ox.ac.uk/about/our-di...

#WIMMSpotlight #WIMMCommunity #Immunology #InnateImmunity #AntiviralResearch #Interferon #PhDStudent #MRCWIMM

#interferon signature: doi.org/10.1016/j.ki...
#prognosis signature: doi.org/10.1681/asn....

Loss of nsp14-exonuclease activity impairs the replication, proofreading, fitness and pathogenesis of SARS-CoV-2 Coronaviruses (CoVs) replicate their RNA genomes with increased fidelity than other RNA viruses, a mechanism mediated by the proofreading and recombination activities of the exoribonuclease domain of ...

Our new preprint on #SARSCoV2 nsp14 #exonuclease function in replication fidelity and fitness. ExoN- viruses are attenuated in vitro and in vivo but w/o #interferon signaling replication is largely restored! Suggests nsp14 plays a role in innate antagonism in vivo www.biorxiv.org/content/10.6...

Dr. @BrandiReeves1 #MPNChallenge ™ study is uncovering how MPNs damage the kidneys and if interferon-alpha might protect them. Donate today to help make more research like Dr. Reeves' a reality: https://goto.mpnresearchfoundation.org/48Xj643

#MPNResearch #RareDisease #Interferon

Oncogenic MUC1-C/M1C protein confers #Osimertinib resistance in #NSCLC cells by driving an inflammatory memory response via the STAT1 and #Interferon type I/II pathways and is a target for M1C ADC treatment. @harvardmed.bsky.social

#OpenAccess: doi.org/10.1038/s413...

DNA fragmentation factor B suppresses interferon to enable cancer persister cell regrowth - Nature Cell Biology Williams et al. report a growth arrest mechanism in residual cancer persister cells through targeted therapy-induced upregulation of type I interferon signalling, which is negatively regulated by apop...

☕Williams et al. report a growth arrest mechanism in residual #cancer persister cells through targeted #therapy - induced upregulation of type I #interferon signalling, which is negatively regulated by apoptotic DNA endonuclease DFFB to allow tumour relapse.
bit.ly/4aibIAN

Dot plot of pathway analysis for MDM vs AM responses

This team effort revealed several interesting findings...

First, we found that while all #macrophages generated strong #interferon responses to Mtb in vitro, AM from both species showed weaker inflammatory responses to Mtb than human MDM or murine BMDM, despite higher baseline levels.

(2/5)

Recent review shows that type I interferon is overactive in kids with lupus, driving inflammation, highlighting key genes, biomarkers, and new treatment options like IFN blockers & JAK inhibitors.

#Meded #SoMe4PedSurg #Pediatrics #PediatricSLE #Interferon

link.springer.com/article/10.1...

Genes and Immunity - Volume 26 Issue 5, October 2025

⏰#October issue of #Genes & #Immunity is online!
👉Read abt #autism, #viral #infection, #inflammatory #bowel #disease #IBD, #Alzheimer #disease, #interferon #responses, #colorectal #cancer, #periodontitis, #microRNA, #lupus, #thymocyte & #celiac #disease
www.nature.com/gene/volumes...

Interferon-sensitized hematopoietic progenitors dynamically alter organismal immunity Abstract. Inflammation has enduring impacts on organismal immunity. However, the precise mechanisms by which tissue-restricted inflammation conditions syst

Your immune system remembers skin inflammation long after it resolves because of #interferon alpha!
Check out our new paper describing these findings just published at
@jimmunol.bsky.social 👇👇👇

It was amazing working on this with my role model @drshrutinaik.bsky.social

This study links the cyclic guanosine monophosphate-adenosine monophosphate synthase & stimulator of #Interferon genes pathway to #Retinal #Inflammation, offering new treatment strategies for #Uveitis. @fudan-university.bsky.social #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

IRF3 in viral infections: more than just triggering the interferon response - Genes & Immunity Genes & Immunity - IRF3 in viral infections: more than just triggering the interferon response

#IRF3 in #viral #infections: more than just triggering the #interferon #response

#Genes & #immunity @springernature.com
www.nature.com/articles/s41...

Kudos to DeRisi and colleagues on this exciting finding.
#interferon #immunity #infection @czbiohub

Get out of London! A track to be played loud ... youtu.be/6u3UNwybclo?...

#Interferon #GetOutOfLondon

Big congrats to Vinnie Graziano @vinnieviruses.bsky.social who led the project and huge thanks to our great collaborators: Jennifer Porat, Thomas Carell, Franck Barrat, Beiyan Zhou, Sivapriya Kailasan Vanaja, Michael Wilson, and Penghua Wang!! #innate_immunity #interferon #celldeath

Differential modulation of #Interferon and Cell Death Responses defines #Human vs Avian #Influenza A Virus Strain-Specific Virulence and guides Combination #Therapy.

Differential modulation of #Interferon and Cell Death Responses defines #Human vs Avian #Influenza A Virus Strain-Specific Virulence and guides Combination #Therapy, etidiohnew.blogspot.com/2025/08/diff...

📈 Last week I had the chance to present my project on the influence of #interferon on antigen processing by the proteasome at the 2nd #Heidelberg Interferon Symposium! 🦠🧬🧫 1/3

Environmental stress drives clearance of a persistent enteric virus in mice - Nature Microbiology Cage change of mice with persistent murine astrovirus infection triggers stress responses marked by corticosterone fluctuation, which is followed by CD8 T cell activation and induction of epithelial a...

#ToStressOrNotToStress! @christinviral.bsky.social @cadwelllab.bsky.social show @naturemicrobiol.nature.com that stress drives #interferon stimulated genes to protect against an enteric virus! After immune suppression by stress-induced glucorticoids, CD8 T cells get activated protecting the host!

🚨🚨 News from the @castello-lab.bsky.social and @shabazlab.bsky.social. Our work, led by Louisa Iselin, reveals pervasive changes in the RNA-bound proteome induced by interferon. #RNA, #immunity, #interferon, #host-virus www.biorxiv.org/content/10.1...

Alternate isoforms of IRF7 Differentially Regulate Interferon Expression to Tune Response to Viral Infection Interferon Regulatory Factor 7 (IRF7), and its homologue IRF3, are master transcriptional regulators of the innate immune response. IRF7 binds to promoters of interferon β (IFNβ) and several IFNαs as ...

Tomorrow, in #PreprintClubHub1 Mount Sinai’s Rachel Geltman ‪@rachelgeltman.bsky.social will present a #preprint from @asmita_panthi about the way alternate isoforms of IRF7 differentially regulate #interferon expression to tune response to viral infection. 7️⃣ 🎶 🤒

www.biorxiv.org/content/10.1...

#IntegratedStressResponse #UnfoldedProteinResponse #DendriticCells #Interferon #ISR #UPR #DCs #IFN @ciml.bsky.social @cnrs.fr @cnrsbiologie.bsky.social @univ-amu.fr