🚀From Bench to Paper | 🧬Science: #MTAP-deficient tumors resist STING agonists by silencing #IRF3 signaling—but this can be reversed via polyamine metabolism targeting.
#E7766, a synthetic cyclic dinucleotide #STING agonist, helped reveal this mechanism.
🌟Get E7766 at MedChemExpress.
#IRF3 in #viral #infections: more than just triggering the #interferon #response
#Genes & #immunity @springernature.com
www.nature.com/articles/s41...
SIRF: Sergio Acebron @acebronsp.bsky.social @cosheidelberg.bsky.social and colleagues develop a new #biosensor reporting on functional interactions between dsDNA sensor STING and #IRF3, allowing to capture STING activation upon various triggers
www.embopress.org/doi/full/10....
