RESEARCH PAPER: UPR deficiency leads to poor growth, aneuploidy, and a trade-off between ER and general proteostasis in yeast
By Bartolutti et al. and Gloria Brar
➡️ https://genesdev.cshlp.org/content/39/23-24/1434.full

#aneuploidy #unfoldedproteinresponse #UPR #proteinfolding #proteostasis #yeast

This recent study shows that NRC activates the #Mitochondrial #UnfoldedProteinResponse and restores #Fundc1-driven #Mitophagy, counteracting #NeuronalDamage and highlighting a novel therapeutic strategy for alcohol-related disorders. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Unfolded protein response - Lasker Foundation Explore All 2014 Winners & Awards > Kazutoshi Mori Kyoto University Peter Walter University of California, San Francisco For discoveries concerning the unfolded protein response — an intracellular…

Happy birthday to Kazutoshi Mori! He won a #LaskerAward for discoveries concerning the #UnfoldedProteinResponse — an intracellular control system that detects harmful misfolded proteins and signals the nucleus to carry out corrective measures. ow.ly/cmtI30oHqdB 🧪

#IntegratedStressResponse #UnfoldedProteinResponse #DendriticCells #Interferon #ISR #UPR #DCs #IFN @ciml.bsky.social @cnrs.fr @cnrsbiologie.bsky.social @univ-amu.fr

Schematic of WRNexo function in Drosophila intestinal stem cells (ISCs). WRNexo upregulation and Hsc70-3/Bip translocation to nuclei occur with injury/aging. WRNexo interaction inhibits Hsc70-3/Bip, increasing ER stress, which promotes ISC proliferation via ROS-JNK signaling.

#WernerSyndrome mutations cause premature #aging, but what's the normal role of this #exonuclease? This study shows that the #Drosophila homolog WRNexo regulates the ER's #UnfoldedProteinResponse in intestinal #StemCells, promoting gut #regeneration after injury @plosbiology.org 🧪 plos.io/42XBYfH

Schematic of WRNexo function in Drosophila intestinal stem cells (ISCs). WRNexo upregulation and Hsc70-3/Bip translocation to nuclei occur with injury/aging. WRNexo interaction inhibits Hsc70-3/Bip, increasing ER stress, which promotes ISC proliferation via ROS-JNK signaling.

#WernerSyndrome mutations cause premature #aging, but what's the normal role of this #exonuclease? This study shows that the #Drosophila homolog WRNexo regulates the ER's #UnfoldedProteinResponse in intestinal #StemCells, promoting gut #regeneration after injury @plosbiology.org 🧪 plos.io/42XBYfH

Schematic of WRNexo function in Drosophila intestinal stem cells (ISCs). WRNexo upregulation and Hsc70-3/Bip translocation to nuclei occur with injury/aging. WRNexo interaction inhibits Hsc70-3/Bip, increasing ER stress, which promotes ISC proliferation via ROS-JNK signaling.

#WernerSyndrome mutations cause premature #aging, but what's the normal role of this #exonuclease? This study shows that the #Drosophila homolog WRNexo regulates the ER's #UnfoldedProteinResponse in intestinal #StemCells, promoting gut #regeneration after injury @plosbiology.org 🧪 plos.io/42XBYfH

RNA exosome-driven RNA processing instructs the duration of the unfolded protein response Abstract. Upon stresses, cellular compartments initiate adaptive programs meant to restore homeostasis. Dedicated to the resolution of transient perturbati

#RNAExosome #Rrp6 #RNAProcessing #Splicing #UPR #UnfoldedProteinResponse #BuddingYeast

academic.oup.com/nar/article/...

🙋 Are you studying the Unfolded Protein Response (UPR) and/or the Integrated Stress Response (ISR)?

👇🏻 Let’s all gather here!

Thank you @profmarciniak.bsky.social!

#UPR #ISR #UnfoldedProteinResponse #IntegratedStressResponse

Cholesterol-induced #SmoothMuscleCell phenotypic plasticity

Activation of KLF4 & atherogenic Macrophage-like or Fibroblast-like features are mediated by #ERStress #UnfoldedProteinResponse (PERK arm)

Dianna Milewicz lab ATVB 2021
www.ahajournals.org/doi/full/10....