Evaluation of GPT-5 in Periodontitis Staging and Grading: Retrospective Observational Study Background: Periodontitis is a chronic gum disease affecting approximately 42% of adults aged 30 years and older in the United States. Training dental students to accurately diagnose and manage periodontitis is a critical component of dental education and clinical care. Recent advances in large language models offer new opportunities to support both domains, yet their performance in periodontal diagnosis remains largely unexplored, particularly for newer models such as GPT-5. Objective: This study conducted an exploratory evaluation of GPT-5’s ability to stage and grade periodontitis. Methods: A total of 25 publicly available clinical cases explicitly reporting periodontitis stage and grade were identified through Google and PubMed searches. Each case description was entered into GPT-5 using a zero-shot prompting approach to assess guideline-based reasoning without exemplar conditioning. The model’s predictions were compared with the published reference diagnoses. Performance was measured using accuracy, 95% CI, unweighted Cohen κ, and weighted Cohen κ. Results: Across these cases, GPT-5 showed marked class-dependent performance and a tendency to overestimate disease severity. Grading performance was notably imbalanced, with high recall for grade C but substantially lower discrimination for grade B. GPT-5 achieved a staging accuracy of 68% (95% CI 48.4%-82.8%) and a grading accuracy of 77.3% (95% CI 56.6%-89.9%), with corresponding Cohen κ values of 0.454 (95% CI 11.0%-75.6%) and 0.179 (95% CI −15.8% to 63.8%), respectively. While staging performance showed fair agreement beyond chance, the low κ for grading indicates poor agreement and limited reliability in distinguishing periodontal disease severity. Conclusions: These findings suggest that although GPT-5 demonstrates potential for guideline-based periodontitis staging and grading, its current diagnostic performance, particularly for periodontitis grading, limits its use in clinical assessment and educational training. Meaningful application in periodontal diagnosis and training will require substantial improvements in reliability and rigorous validation in larger, more diverse, and prospectively collected datasets.

JMIR Formative Res: Evaluation of GPT-5 in Periodontitis Staging and Grading: Retrospective Observational Study #Periodontitis #DentalEducation #GPT5 #OralHealth #ChronicDisease

Denteric Receives FDA IND Approval for Innovative Vaccine Targeting Periodontitis Inflammation Denteric has announced FDA clearance for GPV381, an innovative vaccine aimed at treating inflammation caused by periodontitis. This breakthrough could transform oral health care.

Denteric Receives FDA IND Approval for Innovative Vaccine Targeting Periodontitis Inflammation #United_States #Melbourne #periodontitis #Denteric #GPV381

Gum disease bacterium linked to breast cancer growth and spread A common oral bacterium tied to gum disease may help spark and fuel breast cancer, according to new research. Scientists discovered it can travel through the bloodstream to breast tissue, where it cau...

#mwgic #2026 #GumDisease #Periodontitis #Gingivitis #Cancer #BreastCancer

www.sciencedaily.com/releases/202...

A randomized #ClinicalTrial shows that #Allogeneic dental pulp stem cell injections enhance periodontal regeneration and improve clinical outcomes, thereby supporting a safe, minimally invasive stem-cell therapy for #Periodontitis. @pku1898.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...

Association between HbA1c chairside values and periodontitis Diabetes and prediabetes cases are steadily increasing worldwide every year. Screening and early detection are crucial to reduce complications and the…

Visita al odontólogo puede ser una importante oportunidad para la detección temprana de la hiperglucemia no diagnosticada #HbA1c #periodontitis www.sciencedirect.com/science/arti...

Porphyromonas gingivalis Induces Chronic Kidney Disease through Crosstalk between the NF-κB/NLRP3 Pathway and Ferroptosis in GMCs

This study shows that P. gingivalis induces #CKD in mice via #NFκB/#NLRP3 crosstalk & #Ferroptosis in #Mesangial cells, highlighting the contribution of #Periodontitis to CKD pathogenesis, underscoring the importance of #PeriodontalTherapy. #medsky

To read: doi.org/10.1007/s115...

New Toothpaste Stops Gum Disease Without Harming Healthy Bacteria Researchers have developed a targeted approach to combat periodontitis without disrupting the natural balance of the oral microbiome. The innovation could reshape how gum disease is treated while pres...

#mwgic #2026 #Dentistry #Periodontitis

New Toothpaste Stops Gum Disease Without Harming Healthy Bacteria share.google/PI6I9FRrQH8N...

Gum Disease Tied to Mild Cognitive Impairment in Concerning Link Severe periodontitis was linked to higher odds of mild cognitive impairment risk in middle-aged adults.

Gum Disease Tied to Mild Cognitive Impairment in Concerning Link - AMJ/EMJ
#neurology
#periodontitis

www.emjreviews.com/neurology/ne...

Single-cell profiling of the subgingival bacteria reveals transcriptional heterogeneity and niche-specific programs.

Single‑cell RNA atlas reveals functional shifts in subgingival bacteria driving #periodontitis.

www.sciencedirect.com/science/arti... #OpenAccess #OralHealth #microbiota #MicroSky

Recent Advances in Nanomaterial-Based Biosensor for Periodontitis Detection Can nanoparticles detect gum disease? Review finds plasmonic NPs enhance periodontitis diagnosis. #Periodontitis #Nanoparticles

Can nanoparticles detect gum disease? Review finds plasmonic NPs enhance periodontitis diagnosis. #Periodontitis #Nanoparticles
www.rimpacts.com/rd/p?c=10075... 📄DOI: doi.org/10.1186/s130...

Periodontitis and diabetes: a bidirectional link The bidirectional link between diabetes and periodontitis is well established, but periodontitis remains underdiagnosed in the context of diabetes. Coordinated care could improve inflammation, oral…

The bidirectional link between #diabetes and #periodontitis is well established, but periodontitis remains underdiagnosed in the context of diabetes.

Coordinated care could improve inflammation, oral health, and metabolic outcomes.

👉 buff.ly/3gyLhlu

#DiabetesSky

Frizzled-related Protein modulates mitochondrial function via the Wnt/β-catenin signaling pathway

Cell Regen Research | Frizzled-related protein (FRZB) protects periodontal ligament stem cells from inflammation-induced osteogenic defects!🦷 While inflammation downregulates FRZB and impairs osteogenesis, overexpression restores. #Periodontitis #StemCells
🔗https://doi.org/10.1186/s13619-026-00283-z

#FactCheck Friday! #Periodontitis hasn't been linked with cardiovascular disease, colorectal cancer, GI diseases, adverse pregnancy outcomes, #diabetes, and #Alzheimers. FALSE! It's linked with all of these diseases. Learn more about treatments here: institutionalrepository.aah.org/jpcrr/vol12/...

Okayama University Discover Mechanism Linking Periodontitis to Kidney Inflammation Recent research from Okayama University reveals how periodontal disease may trigger kidney inflammation, potentially aiding disease prevention through oral health.

Okayama University Discover Mechanism Linking Periodontitis to Kidney Inflammation #Japan #periodontitis #Okayama #Okayama_University #Kidney_Inflammation

¿La placa de los dientes también atasca las arterias? La AHA actualiza la evidencia: periodontitis e inflamación oral se asocian a aterosclerosis, infarto e ictus, con datos y límites muy claros. En el baño, frente al espejo, la placa dental parece un as...

¿La placa de los dientes también atasca las arterias? #SaludBucodental #Periodontitis #Aterosclerosis #Corazón #Ictus #Infarto #Odontología #Cardiología #Inflamación #Prevención #PlacaDental #Encías #31deenero #felizsabado #Ciencia donporque.com/placa-de-los...

Photodynamic therapy is another way besides #antibiotics to treat #periodontitis, which damages the tissues that support teeth, as it is cost-effective, well tolerated by patients, and a good option for whom periodontal #surgery is not an option. institutionalrepository.aah.org/jpcrr/vol12/...

Periodontitis causes tooth loss by disrupting oral health. This review helps us understand its molecular drivers, aiding in finding new ways to treat and prevent this painful gum disease.😀
#periodontitis #bone #gum
@brjournal.bsky.social
www.nature.com/articles/s41...

Chronic Obstructive Pulmonary Disease (COPD) worsens with periodontitis, as bacteria travel to the lungs, causing more inflammation. Understanding this link can improve treatment strategies.🤓
#COPD #periodontitis
@ijosjournal.bsky.social
www.nature.com/articles/s41...

Fusobacterium nucleatum y Treponema denticola son biomarcadores robustos para la gingivitis y la periodontitis en perros pequeños - Axon Comunicacion. Empresa líder en comunicación y marketing veterinario Fusobacterium nucleatum y Treponema denticola son biomarcadores robustos para la gingivitis y la periodontitis en perros pequeños

#axónvet #informaciónveterinaria #saludanimal #periodontitis #gingivitis #perro 

Target-seeking toothpaste goes after bacteria that cause gum disease There could be new hope in the fight against gum disease. Scientists have developed a toothpaste that targets only the bacteria that cause periodontitis, leaving the rest of the oral microbiome health...

#mwgic #2026 #Periodontitis #Treatment?

newatlas.com/medical-tech...

New toothpaste stops periodontal pathogens Periodontitis is widespread and can have serious consequences for overall health. Researchers at Fraunhofer have identified a substance that selectively inhibits only those bacteria that cause…

#Toothpaste stops #periodontal #pathogens ...

| #Periodontitis | #health | #oral | #mouth | #microbiome | By @fraunhofer.bsky.social via @sciencex.bsky.social

Is Your Oral Bacteria Influencing Multiple Sclerosis? - Neuroscience News High levels of the periodontal bacterium Fusobacterium nucleatum may be associated with more severe disability in people with multiple sclerosis.

#mwgic #2025 #MS #MultipleSchlerosis
#Periodontitis #OralBacteria

neurosciencenews.com/oral-bacteri...

La inhibición de la catepsina K por VBX1000 alivia la periodontitis canina Información para veterinarios y asistentes en centro veterinario: La inhibición de la catepsina K por VBX1000 alivia la periodontitis canina

La inhibición de la catepsina K por VBX1000 alivia la periodontitis canina
#axónvet #informaciónveterinaria #saludanimal #periodontitis #canina 

Association between stress hyperglycemia ratio and periodontitis among diabetes: evidence from National Health and Nutrition Examination Survey 2009-2014.
Peng, Yuke et al.
Paper
Details
#StressHyperglycemia #Periodontitis #NHANES

¿Por qué el embarazo desordena tu boca (y cómo evitarlo)? El embarazo altera el microbioma oral y favorece gingivitis y caries; datos y pautas seguras en España para prevenir y tratar sin alarmismos. El embarazo altera el ecosistema de la boca en cuestión de...

¿Por qué el embarazo desordena tu boca (y cómo evitarlo)? #Embarazo #SaludBucodental #MicrobiomaOral #Gingivitis #Periodontitis #Caries #Odontología #Gestación #Prevención #España #Flúor #Xilitol #Maternidad #1dediciembre #felizlunes
donporque.com/embarazo-des...

ASOD’s Julie Marchesan, DDS, PhD, and Jenny Y. Ting, PhD, from UNC School Of Medicine, just published groundbreaking findings on the role of sex in periodontitis — a common but debilitating gum disease.

Read more: buff.ly/kPDnwgX

#Periodontitis #DentalResearch #GumDisease #UNCResearch

Research from the University of North Carolina at Chapel Hill has found that a specific inflammatory protein becomes overactive in males, helping explain why men develop dental disease more often and with greater severity than women.

#DentalHealth #UNCResearch #Inflammation #Periodontitis

#FactCheck Friday! Photodynamic therapy (PDT) is another way besides #antibiotics to treat #periodontitis, or #GumDisease. TRUE! PDT is cost-effective, well tolerated by patients, and a good option for those whom periodontal #surgery is not an option. institutionalrepository.aah.org/jpcrr/vol12/...

Inflamación periodontal en los adultos mayores tiene mayor probabilidad de desarrollar elevación de la AST a 3a #periodontitis #AST journals.lww.com/jpcd/fulltex...

Genes and Immunity - Volume 26 Issue 5, October 2025

⏰#October issue of #Genes & #Immunity is online!
👉Read abt #autism, #viral #infection, #inflammatory #bowel #disease #IBD, #Alzheimer #disease, #interferon #responses, #colorectal #cancer, #periodontitis, #microRNA, #lupus, #thymocyte & #celiac #disease
www.nature.com/gene/volumes...