Novel criteria define disease activity in adult-onset Still disease A novel set of clinical criteria for adult-onset Still disease has been developed to classify patients as having active disease, low disease activity, or clinically inactive disease.

#MedNews - A novel set of clinical criteria for adult-onset #StillDisease has been developed to classify patients as having active disease, low disease activity, or clinically inactive disease.

Full story 👉 buff.ly/4oxd5gU

#RheumSky

Updates in the 2025 AHA/ACC Hypertension Guideline A summary of the major updates in the 2025 AHA/ACC hypertension guideline, including replacement of PCEs with the PREVENT risk calculator, adjunctive renal denervation in patients with resistant…

What were the major updates in the 2025 AHA/ACC #hypertension guideline?

This review from Brown et al details the updates, including replacement of PCEs with the PREVENT risk calculator, adjunctive renal denervation in patients with resistant hypertension, and more.

👉 buff.ly/ne4WLYr

#CardioSky

A case of T-prolymphocytic leukemia harboring RAS mutation The first report of a pathogenic KRAS G12A mutation in a patient with T-cell prolymphocytic leukemia. Investigating for KRAS mutations in T-PLL cases could open new avenues for future targeted…

#MedCase - The first report of a pathogenic KRAS G12A mutation in a patient with T-cell prolymphocytic #leukemia.

Investigating for KRAS mutations in T-PLL cases could open new avenues for future targeted therapeutic strategies.

👉 buff.ly/9Hdu7Dp

#OncSky

Oral PCSK9 inhibitor enlicitide beats other nonstatins in reducing LDL-C levels Oral PCSK9 inhibitor enlicitide offers significantly greater reductions in low-density lipoprotein cholesterol levels than other nonstatin therapies when added to first-line statins.

From #ACC2026 - Oral PCSK9 inhibitor #enlicitide offers significantly greater reductions in low-density lipoprotein #cholesterol levels than other nonstatin therapies when added to first-line statins.

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#MedNews

Rapid pulmonary calcification within 10 days in a COVID-19 patient: a case report Pulmonary calcification typically develops over several months following chronic inflammation. This case reports intrapulmonary calcification occurring within 10-days of SARS-CoV-2 infection in a…

#MedCase - Pulmonary calcification typically develops over several months following chronic inflammation.

This case reports intrapulmonary calcification occurring within 10-days of SARS-CoV-2 infection in a previously healthy patient.

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#IDSky #PulmSky #COVID19

Testosterone Supplementation and Other Pharmacotherapy for Sarcopenia in Cirrhosis: Evaluation, Treatment and Considerations Addressing the underlying drivers of sarcopenia in patients with liver cirrhosis is crucial for effective management. This review outlines current pharmacological interventions and the biological…

Addressing the underlying drivers of #sarcopenia in patients with #LiverCirrhosis is crucial for effective management.

This review outlines current pharmacological interventions and the biological rationale behind them.

👉 buff.ly/Z2zjlsz

#HepSky

Recurrent cytokine release syndrome in patients receiving bispecific antibody therapy for multiple myeloma: a case series An unusual pattern of recurrent cytokine release syndrome occurring during bispecific antibody therapy for multiple myeloma. Recognition of this phenomenon is essential to avoid misdiagnosis as…

#MedCase - An unusual pattern of recurrent cytokine release syndrome occurring during bispecific antibody therapy for #MultipleMyeloma.

Recognition of this phenomenon is essential to avoid misdiagnosis as infection.

👉 buff.ly/jNNEPbe

#OncSky

Metabolic and Bariatric Surgery: The Contraindications of the Past are the Indications of the Future MBS has evolved from a last-resort intervention to an effective, evidence-based therapeutic modality for obesity and its related medical conditions. The contraindications of the past are the…

MBS has evolved from a last-resort intervention to an effective, evidence-based therapeutic modality for #obesity and its related medical conditions.

The contraindications of the past are the indications of the future.

👉 buff.ly/qHDO6Xv

#GISky

Research offers reassurance on anti-VEGF use during stroke or MI People who experience stroke or myocardial infarction can continue to receive intravitreal anti-vascular endothelial growth factor therapy without risking increased mortality or morbidity.

#MedNews - People who experience #stroke or myocardial infarction can continue to receive intravitreal anti-VEGF therapy without risking increased mortality or morbidity.

Full story 👉 buff.ly/9lMpNAJ

#EyeSky #VEGF

Levothyroxine discontinuation feasible in some older adults Levothyroxine could be discontinued in around a quarter of adults aged 60 years or older without negatively affecting thyroid function and related quality of life.

#MedNews - #Levothyroxine could be discontinued in around a quarter of adults aged 60 years or older without negatively affecting #thyroid function and related quality of life.

Full story 👉 buff.ly/0G7g2Mn

#EndoSky #Hypothyroidism

Treatment-free remission in MS: long-term disease control with cladribine tablets Cladribine tablets could lead to a paradigmatic shift in multiple sclerosis management that may enable long-term treatment-free remission as an achievable treatment goal in a substantial proportion…

#Cladribine tablets could lead to a paradigmatic shift in #MultipleSclerosis management that may enable long-term treatment-free remission as an achievable treatment goal in a substantial proportion of relapsing patients.

👉 buff.ly/g8r1zf2

#NeuroSky

Persistent electrical storm following strong acid descaling agent ingestion successfully rescued with venoarterial extracorporeal membrane oxygenation: a case report Ingestion of industrial acids resulted in severe GI trauma, recurrent ventricular fibrillation and refractory cardiogenic shock. VA-ECMO, alongside management of metabolic triggers via CRRT, were…

#MedCase - Ingestion of industrial acids resulted in severe GI trauma, recurrent #VFib and refractory cardiogenic shock.

VA-ECMO, alongside management of metabolic triggers via CRRT, were successful in stabilizing the patient.

👉 buff.ly/XUXa2JE

#CardioSky

Switching to INSTIs increases diabetes and cardiometabolic risk in people with HIV Switching people with HIV to an integrase strand transfer inhibitor from a protease inhibitor or non-nucleoside reverse transcriptase inhibitor is associated with an increased risk for diabetes.

#MedNews - Switching people with #HIV to an integrase strand transfer inhibitor from a protease inhibitor or non-nucleoside reverse transcriptase inhibitor is associated with an increased risk for #diabetes.

Full story 👉 buff.ly/EAZt2Rc

#IDSky

A dual catastrophe in the left main coronary artery: iatrogenic dissection and dislodgement of the fully deployed stent A unique scenario in which two rare complications of PCI, iatrogenic LMCA dissection and complete retrograde stent dislodgement, occurred simultaneously in a patient undergoing coronary angiography.

#MedCase - A unique scenario in which two rare complications of #PCI, iatrogenic LMCA dissection and complete retrograde stent dislodgement, occurred simultaneously in a patient undergoing coronary angiography.

👉 buff.ly/9gmSehe

#CardioSky

Robot-assisted esophagectomy noninferior to thoracoscopic surgery for squamous cell carcinoma Comparable long-term survival for patients undergoing robot-assisted or thoracoscopic esophagectomy for resectable esophageal squamous cell carcinoma, suggests the RAMIE trial.

#MedNews - Comparable long-term survival for patients undergoing robot-assisted or thoracoscopic esophagectomy for resectable esophageal squamous cell carcinoma, suggests the RAMIE trial.

Full story 👉 buff.ly/cNj9PYN

#GISky #OncSky

Aspirin in Colorectal Cancer Care: Who to Treat, When, and Why The use of aspirin in colorectal cancer should be targeted rather than routine. This algorithm integrates crucial factors such as absolute CRC risk, PI3K/PIK3CA status, and bleeding risk to maximize…

The use of aspirin in #ColorectalCancer should be targeted rather than routine.

This algorithm integrates crucial factors such as absolute CRC risk, PI3K/PIK3CA status, and bleeding risk to maximize benefit while reducing harm.

👉 buff.ly/4jDuE5R

#OncSky #CRC

Beyond Supportive Care: Mitochondria as a Strategic Therapeutic Avenue in Acute Pancreatitis Mitochondrial dysfunction is an early and pivotal event in acute pancreatitis. Could mitochondria represent an attractive target for therapeutic intervention and how might mitochondria-directed…

Mitochondrial dysfunction is an early and pivotal event in acute #pancreatitis.

Could mitochondria represent an attractive target for therapeutic intervention and how might mitochondria-directed strategies work?

👉 buff.ly/yfjCYvE

#GISky

Oral semaglutide fails to slow AD progression Two phase 3 studies have shown that oral semaglutide does not slow disease progression in people with early Alzheimer disease.

#MedNews - Two phase 3 studies have shown that oral #semaglutide does not slow disease progression in people with early #AlzheimerDisease.

Full story 👉 buff.ly/yup7n2B

#NeuroSky

OCTA in age-related macular degeneration: consensus on practical guidelines for optimal imaging strategies across different clinical scenarios While the versatility of optical coherence tomography angiography makes it a powerful tool in the assessment of age-related macular degeneration, it also presents the challenge of deciding the…

While the versatility of #OCTA imaging makes it a powerful tool in the assessment of #AMD, it also presents the challenge of deciding the appropriate imaging strategy.

Here is what you should consider 👉 buff.ly/N8wtDMG

#EyeSky

GAD65 encephalitis presenting with isolated refractory vomiting: a pivotal mimic of functional disorder FND was initially considered in this 10-year-old patient presenting with refractory vomiting and subsequent functional-neurological episodes, however serological investigations instead confirmed a…

#MedCase - #FND was initially considered in this 10-year-old patient presenting with refractory vomiting and subsequent functional-neurological episodes, however serological investigations instead confirmed a far more unusual diagnosis.

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#NeuroSky

Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026 Guidelines from the Surviving Sepsis Campaign for the management of sepsis and septic shock in children, with guidance on diagnosis, hemodynamic management, post-sepsis mortality risk, and long-term…

Guidelines from the Surviving Sepsis Campaign for the management of #sepsis and #SepticShock in children, with guidance on diagnosis, hemodynamic management, post-sepsis mortality risk, and long-term follow-up.

👉 buff.ly/cTKXYvf

#IDSky #PediatricMed
@intenscaremed.bsky.social

Stroke in autoimmune rheumatic diseases Patients with ARDs have a significantly increased risk for stroke. Review the epidemiology, pathophysiological mechanisms, clinical characteristics, prevention strategies, and post-stroke…

Patients with #ARDs have a significantly increased risk for #stroke.

Review the epidemiology, pathophysiological mechanisms, clinical characteristics, prevention strategies, and post-stroke rehabilitation in this patient population.

👉 buff.ly/KQ66kPC

#RheumSky

Tirzepatide boosts ixekizumab benefits in patients with PsA and obesity Combining ixekizumab with tirzepatide offers additive clinical benefits over ixekizumab alone in the treatment of psoriatic arthritis in patients with overweight or obesity.

#MedNews - Combining #ixekizumab with #tirzepatide offers additive clinical benefits over ixekizumab alone in the treatment of psoriatic #arthritis in patients with overweight or obesity.

Full story 👉 buff.ly/W3uyUrY

#RheumSky

Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2026 The Surviving Sepsis Campaign, a joint initiative from ESICM and SCCM, have published guidelines for the management of sepsis and septic shock including antibiotic optimization, hemodynamic…

The Surviving Sepsis Campaign, a joint initiative from ESICM and SCCM, have published new guidelines for the management of #sepsis and #SepticShock including antibiotic optimization, hemodynamic management, and post-care strategies.

👉 buff.ly/4UitvD4

#IDSky
@intenscaremed.bsky.social

DED is highly prevalent yet challenging to diagnose and treat.

Join us and explore the latest developments in pathogenesis, diagnostics, and therapies, and gain practical guidance on management in busy clinical settings.

Register now 👉 buff.ly/K0dIBLG

#EyeSky #DryEye
@eyejournal.bsky.social

Acute-on-chronic liver failure triggered by postpartum variceal bleeding in a patient with alcohol-associated liver disease The immediate postpartum period is a uniquely vulnerable time for women with alcohol-associated cirrhosis. In this case, postpartum esophageal variceal bleeding after cesarean section precipitated…

#MedCase - The immediate postpartum period is a uniquely vulnerable time for women with alcohol-associated cirrhosis. In this case, postpartum esophageal variceal bleeding after cesarean section precipitated acute-on-chronic liver failure.

👉 buff.ly/Mu2Vh2Y

#HepSky #ALD

Adding RFA to chemotherapy fails to boost survival for locally advanced pancreatic cancer Radiofrequency ablation does not improve overall survival for patients with locally advanced pancreatic cancer who are undergoing chemotherapy and is associated with poorer quality of life.

#MedNews - Radiofrequency ablation does not improve overall survival for patients with locally advanced #PancreaticCancer who are undergoing chemotherapy and is associated with poorer quality of life.

👉 buff.ly/pJPGaeb

#GastroSky #OncSky

Distinct phenotype of primary sclerosing cholangitis-associated inflammatory bowel disease Emerging data support the concept that PSC-associated IBD be viewed as a distinct colitis phenotype that is pathophysiologically linked to PSC rather than as a subtype of ulcerative colitis.

Emerging data support the concept that primary sclerosing #cholangitis-associated #IBD be viewed as a distinct colitis phenotype that is pathophysiologically linked to PSC rather than as a subtype of ulcerative colitis.

👉 buff.ly/aXKcYuO

#GastroSky

Comorbidity-Driven Inflammation in HFpEF: Immune Profiling and Therapeutic Targets Comorbidities, such as obesity, type 2 diabetes, and hypertension, drive distinct immune profiles in HFpEF through dysregulated cytokine signaling. Linking these profiles to HFpEF phenogroups paves…

Comorbidities, such as obesity, T2D, and hypertension, drive distinct immune profiles in #HFpEF through dysregulated cytokine signaling.

Linking these profiles to HFpEF phenogroups paves the way for tailored treatments.

👉 buff.ly/AbOhfxP

#CardioSky

Aortic dissection in a Jehovah’s witness: Frozen Elephant Trunk and subsequent 4D flow MRI analysis, a case report Thoracic aortic surgery in patients who refuse blood poses unique challenges. In this case, a bloodless surgical strategy using the frozen elephant trunk technique was successful in treating acute…

#MedCase - Thoracic aortic surgery in patients who refuse blood poses unique challenges. In this case, a bloodless surgical strategy using the frozen elephant trunk technique was successful in treating acute type A aortic dissection.

👉 buff.ly/8ksVYR2

#CardioSky #SurgerySky