Novel definition reveals true burden of pediatric sepsis in the USA A new EHR-based definition reveals pediatric sepsis affects over 1% of hospitalizations with 10% mortality, highlighting a substantial and underrecognized burden.

#MedNews - A new EHR-based definition reveals pediatric #sepsis affects over 1% of hospitalizations with 10% mortality, highlighting a substantial and underrecognized burden.

Full story 👉https://buff.ly/hq9NQdn

#IDSky #PediatricMed

Novel advances in juvenile idiopathic arthritis associated uveitis Juvenile idiopathic arthritis-associated uveitis is an important cause of childhood and adult visual impairment. Explore recent developments in disease stratification, imaging, pharmacologic…

Juvenile idiopathic #arthritis-associated uveitis is an important cause of childhood and adult visual impairment.

Explore recent developments in disease stratification, imaging, pharmacologic management, and psychosocial support.

👉 buff.ly/CB2Yrna

#RheumSky #PediatricMed

The Use of Targeted Therapy in Pediatric Acute Lymphoblastic Leukemia: Exploring Novel Approaches and Emerging Therapies Targeted therapies could transform the treatment of pediatric acute lymphoblastic leukemia. Take a deep dive into the mechanistic aspects of the agents, ongoing and recent clinical trial results and…

Targeted therapies could transform the treatment of pediatric #ALL.

Take a deep dive into the mechanistic aspects of the agents, ongoing and recent clinical trial results and approvals, and the side effects of each modality.

👉 buff.ly/L21BPeS

#OncSky #PediatricMed

Management of andrological disorders from childhood and adolescence to transition age: guidelines from the Italian Society of Andrology and Sexual Medicine (SIAMS) in collaboration with the Italian Society for Pediatric Endocrinology and Diabetology (SIEDP) – part-2 Practical guidance for the diagnosis, management, and treatment of pediatric andrological disorders, including cryptorchidism, micropenis, hypospadias, and differences in sex development.

Discover practical guidance for the diagnosis, management, and treatment of pediatric andrological disorders, including cryptorchidism, micropenis, hypospadias, and differences in sex development.

👉 buff.ly/HVKbgpO

#EndoSky #PediatricMed

Extra clinical signs may improve sepsis diagnosis in limited-resource settings A systematic review and meta-analysis has identified novel clinical signs that may aid the diagnosis of sepsis in young infants.

#MedNews - A systematic review and meta-analysis has identified novel clinical signs that may aid the diagnosis of #sepsis in young infants.

Full story 👉 buff.ly/2yUX7OU

#IDSky #PediatricMed

Liver transplant success drops in age-mismatched pairings Adolescent patients receiving a liver transplant from an age-mismatched donor are less likely to have their graft survive beyond 10 years than those with an age-matched donor.

#MedNews - Adolescent patients receiving a #LiverTransplant from an age-mismatched donor are less likely to have their graft survive beyond 10 years than those with an age-matched donor.

Full story 👉 buff.ly/BKh0kLy

#HepSky #PediatricMed

IL-6 shows promise as diagnostic biomarker for sepsis in high-risk populations Interleukin-6 shows promise as a biomarker to diagnose sepsis early in high-risk patient groups such as neonates, children, and pregnant women.

From #ESCMID2025 - Interleukin-6 shows promise as a biomarker to diagnose #sepsis early in high-risk patient groups such as neonates, children, and pregnant women.

Full story 👉 buff.ly/RQwK5v9

#IDMed #PediatricMed

From novel gene therapies to the integration of AI in diagnostics and monitoring, 2025 saw several exciting breakthroughs in pediatrics.

Catch-up on the top 10 stories in the thread below!

#PediatricMed

Vision-threatening complications of injection sclerotherapy: case report, literature review, and FAERS database analysis Sclerotherapy is minimally invasive and generally safe, but local facial injections carry unique risks. In this pediatric patient, progressive ophthalmic artery occlusion following foamed polidocanol…

#MedCase - #Sclerotherapy is minimally invasive and generally safe, but local facial injections carry unique risks.

In this pediatric patient, progressive OAO following foamed polidocanol injection led to irreversible blindness.

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#EyeSky #PediatricMed

Delve into these consensus recommendations from an international panel of experts on the use of lung ultrasound to optimize the management of neonatal respiratory distress.

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#PediatricMed

Ophthalmic apraclonidine use in children may cause serious systemic events Children aged 6 years or younger given apraclonidine ophthalmic drops may be at high risk for developing serious central nervous system and cardiorespiratory adverse events.

#MedNews - Children aged 6 years or younger given #apraclonidine ophthalmic drops may be at high risk for developing serious central nervous system and cardiorespiratory adverse events.

Full story 👉 buff.ly/aG2Rbbh

#EyeSky #PediatricMed

Colorectal adenocarcinoma in children and adolescents: the management of advanced disease Colorectal cancer is very rare in children and adolescents. And due to the generally highly aggressive nature and a low index of suspicion in this population, diagnosis can be delayed and lead to a…

#MedCase - Colorectal cancer is very rare in children and adolescents.

Due to the generally highly aggressive nature and a low index of suspicion in this population, diagnosis can be delayed and lead to a very poor prognosis.

👉 buff.ly/jYDzDYv

#OncSky #CRC #PediatricMed

#MedCase - Pulmonary involvement in neonatal #lupus is extremely rare, but it is important to consider lupus pneumonitis in newborns with unexplained respiratory failure, especially if the mother has an autoimmune disease.

👉 buff.ly/WDwdrvE

#PediatricMed

The Heart Under Pressure: Traumatic Gerbode Defect and Aortic Dissection After a Tire Explosion: A Case Report and Literature Review A case of a 13-year-old boy who sustained multiple traumatic cardiac injuries following a high-pressure truck tyre explosion. Patient was treated for entricular septal and Gerbode defects, aortic…

#MedCase - A case of a 13-year-old boy who sustained multiple traumatic cardiac injuries following a high-pressure truck tire explosion.

Despite the injuries, the patient made a full recovery following extensive surgical interventions.

👉 buff.ly/d8YSn3e

#CardioSky #PediatricMed

Asymptomatic ALCAPA with Preserved Myocardial Function in a 3-Year-Old Child Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital anomaly, rarer still is survival beyond infancy without surgical correction. This case reports the…

#MedCase - #ALCAPA is a rare congenital anomaly, rarer still is survival beyond infancy without surgical correction.

This case reports the successful treatment of an asymptomatic 3-year-old with minimal myocardial injury.

👉 buff.ly/ozMBl8o

#CardioSky #PediatricMed

Neurological involvement in children with familial Mediterranean fever: a systematic review Children with familial Mediterranean fever may present with a range of neurological manifestations. It is important to conduct a comprehensive neurological assessment to enable early detection.

Children with familial Mediterranean fever may present with a range of neurological manifestations.

It is important to conduct a comprehensive neurological assessment to enable early detection.

Find out more 👉https://buff.ly/faoynpn

#RheumSky #NeuroSky #PediatricMed

A case of slowly progressive type 1 diabetes accompanied by positivity for a single islet cell antibody, initially suspected to be childhood-onset type 2 diabetes or maturity-onset diabetes of the young Investigation of glucosuria in a girl aged 11 years indicated the presence of childhood-onset type 2 diabetes, but her presentation with diabetic ketoacidosis 8 years later led to a different…

#MedCase - Investigation of glucosuria in a girl aged 11 years indicated the presence of childhood-onset type 2 diabetes, but her presentation with diabetic ketoacidosis 8 years later led to a different diagnosis.

Find out more 👉 buff.ly/iwzPGB6

#DiabetesSky #PediatricMed

Surgery for childhood glaucoma fails in nearly half of cases Nearly half of all eye surgeries for childhood glaucoma fail within a year, mainly due to insufficient intraocular pressure reduction requiring additional medication.

#MedNews - Nearly half of all eye surgeries for childhood #glaucoma fail within a year, mainly due to insufficient intraocular pressure reduction requiring additional medication.

Full story 👉 buff.ly/7dMex9M

#EyeSky #PediatricMed

Gastrointestinal health and nutritional strategies in autism spectrum disorder Children with ASD may have a greater risk of gastrointestinal disorders and require more intensive nutritional management than neurotypical peers. How should gastrointestinal symptoms in this…

Children with #ASD may have a greater risk of GI disorders and require more intensive nutritional management than neurotypical peers.

How should GI symptoms in this population be managed?

Find out in this #EdsChoice review 👉https://buff.ly/QooYSY4

#GastroSky #Autism #PediatricMed

Clinical Management of Dyslipidemia in Infants and Toddlers Although rare and difficult to diagnose, dyslipidemia does occur in children under 2 years old, with broad etiology and acute and chronic consequences. Discover the pathophysiology and potential…

#Dyslipidemia can occur in children under 2 years old, with broad etiology and acute and chronic consequences.

Discover the pathophysiology and potential treatment options for dyslipidemia in infants in this review.

👉https://buff.ly/800Crdn

#CardioSky #PediatricMed

Congenital mesenteric absence of mid-gut with ileal volvulus: a case report A 4-year-old boy with intestinal obstruction underwent laparoscopy. A large mesenteric defect was found, along with a single mesenteric vessel that had trapped the distal ileum.

#MedCase - A 4-year-old boy with intestinal obstruction underwent #laparoscopy.

A large mesenteric defect was found, along with a single mesenteric vessel that had trapped the distal ileum.

Read the full case 👉 buff.ly/EPJmonc

#GastroSky #PediatricMed #SurgerySky

Breakthrough gene-editing therapy helps infant with rare disorder A customized gene-editing approach has been used for the first time to treat a rare genetic condition in an infant.

#MedNews - A customized gene-editing approach has been used for the first time to treat severe #CPS1 deficiency, a rare genetic condition, in an infant.

Full story 👉 buff.ly/930Deib

#GeneEditing #GeneTherapy #PediatricMed #MedSky

Heterotopic pancreatic tissue presenting as an unusual cause of gastric outlet obstruction in infancy: a case report A 2-month-old girl presented with repeated projectile nonbilious vomiting. What was the cause of her hugely dilated stomach, prepyloric stricture, and delayed gastric emptying?

#MedCase - A 2-month-old girl presented with repeated projectile nonbilious vomiting. What was the cause of her hugely dilated stomach, prepyloric stricture, and delayed gastric emptying?

Discover, in this #EdsChoice case 👉 buff.ly/r8lF2KR

#GastroMed #PediatricMed

Childhood obesity: The threatening apprentice of the adiposity empire Childhood obesity is a growing global health concern, but how should obesity be defined and measured in children, and how does it impact health in the short and long term?

Childhood #obesity is a growing global health concern, but how should obesity be defined and measured in children, and how does it impact health in the short and long term?

Discover in this #EdsChoice review 👉 buff.ly/MYrEHnl

#MedSky #PediatricMed